FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\zae(bx)
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General Information
Symbol
Dmel\zae(bx)
Species
D. melanogaster
Name
FlyBase ID
FBal0018840
Feature type
allele
Associated gene
Dmel\z
Associated Insertion(s)
Carried in Construct
Also Known As
e(bx)
Key Links
Allele class

amorphic allele - genetic evidence

loss of function allele

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Mariani et al., 1985)

hypomorphic allele - genetic evidence

(Chen and Pirrotta, 1993)

loss of function allele

(Leiserson et al., 1994)
Mutagen
gamma ray
(Lewis, 1959)
Progenitor genotype
Caused by aberration
In(1)zae(bx)
Cytology
Description

Inversion breakpoint truncates the protein at amino acid position 310.

(Leiserson et al., 1994)

An inversion removes the 3' half of the z gene.

(Walter et al., 1994)

Breakpoint in middle of z coding region.

(Chen and Pirrotta, 1993)

Lacks about 800 nucleotides of the zeste coding region, but otherwise the 5' half of the mutant gene is normal (Pirrotta, Manet, Hardon, Bickel and Benson, 1987). The transcript of 1.4-1.8 kb (Mariani, Pirrotta and Manet, 1985; Gunaratne, Mansukhani, Lipari, Liou, Martindale and Goldberg, 1986) ends shortly after the 3A3 breakpoint of the inversion <up>breakpoint placed on molecular map of zeste at about +2.0 kb, the origin being the first EcoRI site in clone CS1014 (Gunaratne, Mansukhani, Lipari, Liou, Martindale and Goldberg, 1986)</up>.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Males have dull brown eye color in zv77h background.

      (Chen and Pirrotta, 1993)

      Eye colour: nearly wild-type, but very slightly variegated.

      (Lewis, 1959)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      zae(bx) is an enhancer of visible | dominant phenotype of snaSco

      (Fuse et al., 1999)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      zae(bx) is an enhancer of macrochaeta phenotype of snaSco

      (Fuse et al., 1999)

      zae(bx) is an enhancer of metathoracic laterotergite phenotype of Ubx1

      (Lewis, 1959)

      zae(bx) is an enhancer of haltere phenotype of Ubxpbx-1

      (Lewis, 1959)

      zae(bx) is an enhancer of metathoracic laterotergite phenotype of Ubxbx-34e

      (Lewis, 1959)

      zae(bx) is an enhancer of phenotype of Ubxunspecified

      (Lewis, 1959)

      zae(bx) is an enhancer of haltere phenotype of Ubxbx-3

      (Lewis, 1959)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Enhances the bristle loss phenotype of Tp(2;2)Sco/+ flies.

      (Fuse et al., 1999)

      Nonspecific recessive enhancer of "bithorax" alleles of Ubx. Enhances the development of the dorsal metanotum in Ubxbx-34e/Ubx1 from a few hairs to a broad band of hairy tissue somewhat like that seen in Ubxbx-34e homozygotes. The posterior portion of the halteres shows a slight wing-like modification in Ubxbx-3/Ubxpbx-1 flies. This phenotype is enhanced by zae(bx).

      (Lewis, 1959)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      E.B. Lewis, Feb. 1953.

      Comments
      Comments

      Does not support transvection at dpp or Ubx.

      Does not support transvection effects at Ubx. Can produce a peptide that includes the z DNA binding domain and can modify the phenotype of weak z alleles.

      (Chen and Pirrotta, 1993)

      Antibody binding is abolished.

      (Walter et al., 1994)

      Suppresses of eya2/eya4 transvection.

      (Leiserson et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      e(bx)
      (Bickel and Pirrotta, 1990, Mariani et al., 1985)
      e-bx
      (Lewis, 1998)
      en-bx
      (Lewis, 1959)
      zae(bx)
      Name Synonyms
      Secondary FlyBase IDs
        References (19)