FlyBase Allele Report: Dmel\faf[BX4]

General Information

Symbol

Dmel\faf^BX4

Species

D. melanogaster

Name

FlyBase ID

FBal0028189

Feature type

allele

Associated gene

Dmel\faf

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Fischer-Vize et al., 1992)

loss of function allele

(Isaksson et al., 1997)

Mutagen

X ray

(Fischer-Vize et al., 1992)

Progenitor genotype

Caused by aberration

In(3R)faf^BX4

Cytology

Description

Inversion breakpoint in exon 3.

(Chen and Fischer, 2000)

Inversion breakpoint falls in coding region of faf.

(Fischer-Vize et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

ameliorates epilepsy

modeled by pk^sple-1

(Paemka et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Fischer-Vize et al., 1992)

viable

(Isaksson et al., 1997)

visible

(Huang and Fischer-Vize, 1996)

visible (with faf^FO8)

(Chen and Fischer, 2000, Chen et al., 2000)

visible | recessive

(Fischer-Vize et al., 1992)

Phenotype Manifest In

eye

(Huang et al., 1995)

eye (with faf^FO8)

(Chen and Fischer, 2000)

eye photoreceptor cell

(Li et al., 1997)

eye photoreceptor cell (with faf^FO8)

(Chen et al., 2000)

eye photoreceptor cell & ommatidium | ectopic | somatic clone

(Overstreet et al., 2004)

eye photoreceptor cell | increased number (with faf^FO8)

(Chen and Fischer, 2000)

ommatidium

(Huang and Fischer-Vize, 1996)

ommatidium (with faf^FO8)

(Chen and Fischer, 2000, Chen et al., 2000)

photoreceptor cell R1 | ectopic

(Isaksson et al., 1997)

photoreceptor cell R2 | ectopic

(Isaksson et al., 1997)

photoreceptor cell R3 | ectopic

(Isaksson et al., 1997)

photoreceptor cell R4 | ectopic

(Isaksson et al., 1997)

photoreceptor cell R5 | ectopic

(Isaksson et al., 1997)

photoreceptor cell R6 | ectopic

(Isaksson et al., 1997)

Detailed Description

Statement

Reference

faf^BX4 homozygous somatic clones in the eye lead to the formation of ommatidia containing one additional photoreceptor cell. For an ommatidium to show this phenotype, it is sufficient for 2 of the photoreceptors R2 to R5 to be mutant, but no particular cell of this group need be.

(Overstreet et al., 2004)

The external surface of the eye is irregular in faf^FO8/faf^BX4 flies and most facets contain more than the wild-type number of photoreceptor cells.

(Chen and Fischer, 2000)

faf^BX4/faf^FO8 flies have a rough eye phenotype, due to the ommatidia containing more than the normal number of photoreceptor cells.

(Chen et al., 2000)

BrdU incorporation resembles wild type in faf^FO8/faf^BX4 third larval instar eye discs.

(Chen et al., 2000)

Most facets of homozygotes contain more than the normal complement of 8 photoreceptor cells, many facets have extra R7 cells and a small proportion have missing R7 cells.

(Li et al., 1997)

Mutation causes no significant alteration to the variegated eye phenotype of In(1)w^m4h.

(Henchoz et al., 1996)

Average fraction of wild type facets is ~4.5%.

(Huang et al., 1995)

Eyes roughened due to abnormalities in the hexagonal facet array: most facets include 1-3 extra outer photoreceptor cells which are probably mystery cells. Ovaries of homozygous females are normal in appearance but the embryos produced never form syncytial blastoderm and all fail to hatch.

(Fischer-Vize et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

faf^BX4 has visible phenotype, enhanceable by aop^yan-1/aop[+]

(Isaksson et al., 1997)

Suppressed by

Statement

Reference

faf^FO8/faf^BX4 has visible phenotype, suppressible by Mmus\Usp9x^-.ro

(Chen et al., 2000)

faf^FO8/faf^BX4 has visible phenotype, suppressible by Mmus\Usp9x^+.ro

(Chen et al., 2000)

faf^BX4 has visible phenotype, suppressible by pnt¹²⁷⁷

(Isaksson et al., 1997)

faf^BX4 has visible phenotype, suppressible by pnt[+]/pnt^Δ88

(Isaksson et al., 1997)

faf^BX4 has visible phenotype, suppressible by Jra^IA109/Jra[+]

(Isaksson et al., 1997)

faf^BX4 has visible phenotype, suppressible by 14-3-3ζ^E16/14-3-3zeta[+]

(Isaksson et al., 1997)

Enhancer of

Statement

Reference

faf^BX4 is an enhancer of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

NOT Enhancer of

Statement

Reference

faf^BX4 is a non-enhancer of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

Suppressor of

Statement

Reference

faf^BX4/faf[+] is a suppressor of bang sensitive | dominant phenotype of pk^sple-1

(Paemka et al., 2015)

NOT Suppressor of

Statement

Reference

faf^BX4 is a non-suppressor of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

Other

Statement

Reference

faf^BX4, sev¹⁴ has visible phenotype

(Isaksson et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

faf^BX4 has photoreceptor cell R1 | ectopic phenotype, enhanceable by aop^yan-1/aop[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R2 | ectopic phenotype, enhanceable by aop^yan-1/aop[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R3 | ectopic phenotype, enhanceable by aop^yan-1/aop[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R4 | ectopic phenotype, enhanceable by aop^yan-1/aop[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R5 | ectopic phenotype, enhanceable by aop^yan-1/aop[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R6 | ectopic phenotype, enhanceable by aop^yan-1/aop[+]

(Isaksson et al., 1997)

Suppressed by

Statement

Reference

faf^FO8/faf^BX4 has eye phenotype, suppressible by lqf^+t19G

(Cadavid et al., 2000)

faf^FO8/faf^BX4 has eye phenotype, suppressible by lqf^ro.Tag:FLAG

(Cadavid et al., 2000)

faf^FO8/faf^BX4 has ommatidium phenotype, suppressible by Mmus\Usp9x^+.ro

(Chen et al., 2000)

faf^FO8/faf^BX4 has ommatidium phenotype, suppressible by Mmus\Usp9x^-.ro

(Chen et al., 2000)

faf^BX4 has photoreceptor cell R1 | ectopic phenotype, suppressible by pnt¹²⁷⁷

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R2 | ectopic phenotype, suppressible by pnt¹²⁷⁷

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R3 | ectopic phenotype, suppressible by pnt¹²⁷⁷

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R4 | ectopic phenotype, suppressible by pnt¹²⁷⁷

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R5 | ectopic phenotype, suppressible by pnt¹²⁷⁷

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R6 | ectopic phenotype, suppressible by pnt¹²⁷⁷

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R1 | ectopic phenotype, suppressible by pnt[+]/pnt^Δ88

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R2 | ectopic phenotype, suppressible by pnt[+]/pnt^Δ88

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R3 | ectopic phenotype, suppressible by pnt[+]/pnt^Δ88

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R4 | ectopic phenotype, suppressible by pnt[+]/pnt^Δ88

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R5 | ectopic phenotype, suppressible by pnt[+]/pnt^Δ88

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R6 | ectopic phenotype, suppressible by pnt^Δ88

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R1 | ectopic phenotype, suppressible by Jra^IA109/Jra[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R2 | ectopic phenotype, suppressible by Jra^IA109/Jra[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R3 | ectopic phenotype, suppressible by Jra^IA109/Jra[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R4 | ectopic phenotype, suppressible by Jra^IA109/Jra[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R5 | ectopic phenotype, suppressible by Jra^IA109/Jra[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R6 | ectopic phenotype, suppressible by Jra^IA109/Jra[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R1 | ectopic phenotype, suppressible by 14-3-3ζ^E16/14-3-3zeta[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R2 | ectopic phenotype, suppressible by 14-3-3ζ^E16/14-3-3zeta[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R3 | ectopic phenotype, suppressible by 14-3-3ζ^E16/14-3-3zeta[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R4 | ectopic phenotype, suppressible by 14-3-3ζ^E16/14-3-3zeta[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R5 | ectopic phenotype, suppressible by 14-3-3ζ^E16/14-3-3zeta[+]

(Isaksson et al., 1997)

faf^BX4 has photoreceptor cell R6 | ectopic phenotype, suppressible by 14-3-3ζ^E16

(Isaksson et al., 1997)

faf^BX4 has phenotype, suppressible by Scer\GAL4^h-1J3

(Huang and Fischer-Vize, 1996)

faf^BX4 has phenotype, suppressible by Scer\GAL4^h-H10

(Huang and Fischer-Vize, 1996)

Enhancer of

Statement

Reference

faf^BX4 is an enhancer of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

NOT Enhancer of

Statement

Reference

faf^BX4 is a non-enhancer of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

Suppressor of

Statement

Reference

faf^BX4 is a suppressor of synaptic vesicle phenotype of hiw^unspecified

(DiAntonio et al., 2001)

faf^FO8/faf^BX4 is a suppressor of synaptic vesicle phenotype of hiw^unspecified

(DiAntonio et al., 2001)

NOT Suppressor of

Statement

Reference

faf^BX4 is a non-suppressor of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

faf^FO8/faf^BX4 is a non-suppressor of synapse phenotype of hiw^unspecified

(DiAntonio et al., 2001)

faf^BX4 is a non-suppressor of synapse phenotype of hiw^unspecified

(DiAntonio et al., 2001)

Other

Statement

Reference

faf^BX4, sev¹⁴ has photoreceptor cell R7 phenotype

(Isaksson et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of faf^BX4/+ rescues the bang-sensitive phenotype of pk^sple-1/+ mutants.

(Paemka et al., 2015)

The addition of either homozygous faf^BX4, or faf^BX4/faf^FO8 suppresses the physiological phenotype of hiw^unspecified, leading to a more tha doubling of both quantal content and mEJP frequency. However the synaptic overgrowth phenotype is not affected.

(DiAntonio et al., 2001)

The faf^FO8/faf^BX4 eye phenotype is completely suppressed by one copy of lqf^+t19G or lqf^{ro.T:Zzzz\FLAG}.

(Cadavid et al., 2000)

The extra outer photoreceptor cell phenotype is suppressed by pnt¹²⁷⁷ : faf^BX4 ; pnt¹²⁷⁷ double homozygotes have an average of 6.2 outer photoreceptor cells per ommatidium. The extra outer photoreceptor cell phenotype is dominantly suppressed by pnt^Δ88, by 14-3-3ζ^E16 and also by Jra^IA109. The extra outer photoreceptor cell phenotype is dominantly enhanced by aop^yan-1 : aop^yan-1/+ ; faf^BX4/faf^BX4 flies have an average of 8.7 outer photoreceptor cells per ommatidium. Does not alter the outer photoreceptor cell phenotype of phl¹²/Y males. 60% of sev¹⁴; faf^BX4 double homozygous ommatidia have an R7 cell.

(Isaksson et al., 1997)

Suppression appears to be due to the presence of Scer\GAL4 protein ahead of the furrow.

(Huang and Fischer-Vize, 1996)

Xenogenetic Interactions

Statement

Reference

Mmus\Usp9x^+.ro or Mmus\Usp9x^-.ro rescue nearly completely the eye phenotype of faf^BX4/faf^FO8 flies.

(Chen et al., 2000)

Complementation and Rescue Data

Fails to complement

faf^EP381.faf-

(DiAntonio et al., 2001)

Rescued by

faf^FO8/faf^BX4 is rescued by faf^ro.Tag:MYC

(Chen and Fischer, 2000)

faf^BX4 is rescued by faf^hs.Tag:MYC

(Huang and Fischer-Vize, 1996)

faf^BX4 is rescued by faf^ro.Tag:MYC

(Huang and Fischer-Vize, 1996)

faf^BX4 is rescued by faf^+t13

(Huang et al., 1995)

faf^BX4 is rescued by faf^+t13

(Fischer-Vize et al., 1992)

faf^BX4 is rescued by faf^+t14

(Fischer-Vize et al., 1992)

faf^BX4 is rescued by faf^+t17

(Fischer-Vize et al., 1992)

Partially rescued by

faf^FO8/faf^BX4 is partially rescued by faf^{Δ2.ro.Tag:MYC}

(Chen and Fischer, 2000)

faf^FO8/faf^BX4 is partially rescued by faf^{Δ1.ro.Tag:MYC}

(Chen and Fischer, 2000)

faf^FO8/faf^BX4 is partially rescued by faf^{Δ6.ro.Tag:MYC}

(Chen and Fischer, 2000)

faf^FO8/faf^BX4 is partially rescued by faf^{Δ4.ro.Tag:MYC}

(Chen and Fischer, 2000)

faf^FO8/faf^BX4 is partially rescued by faf^{Δ3.ro.Tag:MYC}

(Chen and Fischer, 2000)

faf^FO8/faf^BX4 is partially rescued by faf^{Δ5.ro.Tag:MYC}

(Chen and Fischer, 2000)

faf^BX4 is partially rescued by faf^glrs

(Huang and Fischer-Vize, 1996)

faf^BX4 is partially rescued by faf^hs.Tag:MYC

(Huang et al., 1995)

Not rescued by

faf^BX4 is not rescued by faf^UAS.cHa/Scer\GAL4^sca-T3

(Huang and Fischer-Vize, 1996)

faf^BX4 is not rescued by faf^UAS.cHa/Scer\GAL4^sca-4512

(Huang and Fischer-Vize, 1996)

faf^BX4 is not rescued by Scer\GAL4^elav-C155/faf^UAS.cHa

(Huang and Fischer-Vize, 1996)

faf^BX4 is not rescued by faf^UAS.cHa/Scer\GAL4^h-1J3

(Huang and Fischer-Vize, 1996)

faf^BX4 is not rescued by faf^sev.PH

(Huang and Fischer-Vize, 1996)

faf^BX4 is not rescued by faf^glrl

(Huang and Fischer-Vize, 1996)

Comments

faf^{hs.T:Hsap\MYC} and faf^{ro.T:Hsap\MYC} can nearly completely rescue the eye phenotype, faf^glrs partially rescues and, faf^glrl and faf^sev.PH fail to rescue.

(Huang and Fischer-Vize, 1996)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

25107

w^*; st¹ faf^BX4/TM6B, Tb¹

25102

P{UAS-faf.H}2, w^*; st¹ faf^BX4/TM6B, Tb¹

Notes on Origin

Discoverer

Comments

No interaction with P{sev-svp1} or P{sev-svp2} exists.

(Begemann et al., 1995)

Very weak faf allele.

(Huang and Fischer-Vize, 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Bx4

(Kaltenbach et al., 2007)

faf^BX4

(Dawson et al., 2025, Clarembaux-Badell et al., 2022, Paemka et al., 2015, Strutt et al., 2013, Yagi et al., 2013, Lee et al., 2012, Buff et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (22)

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