FlyBase Allele Report: Dmel\ct[2s]

General Information

Symbol

Dmel\ct^2s

Species

D. melanogaster

Name

FlyBase ID

FBal0030976

Feature type

allele

Associated gene

Dmel\ct

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Dorsett, 1993, Mogila et al., 1992)

Progenitor genotype

Cytology

Description

Small deletion that specifically disrupts function of the ct wing margin enhancer.

(Micchelli et al., 1997)

Deletion of the wing enhancer.

(Melnikova et al., 1996)

Deletion of sequences within the wing margin enhancer.

(Morcillo et al., 1996)

P-element generated deficiency that deleted the wing margin enhancer.

(Dorsett, 1993)

P element at 7B deleted (chromosome in situ hybridisation), Southern blots show deletion of 1.6kb approximately -124kb with respect to the start of transcription of ct. No Stalker element detectable by chromosome in situ hybridisation at 7B.

(Mogila et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Dorsett, 1993)

viable

(Morcillo et al., 1996)

visible

(Krupp et al., 2005)

visible | recessive

(Rollins et al., 1999, Mogila et al., 1992)

Phenotype Manifest In

wing

(Rollins et al., 1999, Melnikova et al., 1996, Dorsett, 1993)

wing blade

(Krupp et al., 2005)

wing margin bristle

(Krupp et al., 2005)

Detailed Description

Statement

Reference

Hemizygotes show a reduction in the numbers of wing margin bristles and and incised wing margin and wing blade.

(Krupp et al., 2005)

Homozygous females show a severe cut wing phenotype.

(Rollins et al., 1999)

Strong ct wing phenotype.

(Dorsett, 1993)

Strong phenotype, comparable to ct⁶: sharply cut wings.

(Mogila et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ct^2s has visible | dominant phenotype, enhanceable by T(2;3)Nipped-C138.2

(Rollins et al., 1999)

ct^2s has visible | dominant phenotype, enhanceable by Df(2R)Nipped-E338

(Rollins et al., 1999)

ct^2s has visible | dominant phenotype, enhanceable by Df(2R)M41A8

(Rollins et al., 1999)

ct^2s has visible | dominant phenotype, enhanceable by Df(2R)Nipped-C160.1

(Rollins et al., 1999)

ct^2s has visible | dominant phenotype, enhanceable by Df(2R)Nipped-D341.1

(Rollins et al., 1999)

ct^2s has visible | dominant phenotype, enhanceable by Df(2R)Nipped-D263.3

(Rollins et al., 1999)

ct^2s has visible | dominant phenotype, enhanceable by Df(2R)Nipped-E299.1

(Rollins et al., 1999)

ct^2s has visible | dominant phenotype, enhanceable by Df(2R)Nipped-E43

(Rollins et al., 1999)

Suppressed by

Statement

Reference

ct^2s has visible phenotype, suppressible by Scer\GAL4^bbg-C96/BacA\p35^UAS.cHa

(Krupp et al., 2005)

Other

Statement

Reference

Nipped-A^222.3, ct^2s has visible | dominant phenotype

(Rollins et al., 1999)

Nipped-B⁴, ct^2s has visible | dominant phenotype

(Rollins et al., 1999)

RpL38^45-72, ct^2s has visible | dominant phenotype

(Rollins et al., 1999)

Nipped-A^394.2, ct^2s has visible | dominant phenotype

(Rollins et al., 1999)

Nipped-B^292.1, ct^2s has visible | dominant phenotype

(Rollins et al., 1999)

Nipped-B^359.1, ct^2s has visible | dominant phenotype

(Rollins et al., 1999)

Nipped-B⁴⁰⁷, ct^2s has visible | dominant phenotype

(Rollins et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

ct^2s has wing phenotype, enhanceable by T(2;3)Nipped-C138.2

(Rollins et al., 1999)

ct^2s has wing phenotype, enhanceable by Df(2R)Nipped-E338

(Rollins et al., 1999)

ct^2s has wing phenotype, enhanceable by Df(2R)Nipped-C160.1

(Rollins et al., 1999)

ct^2s has wing phenotype, enhanceable by Df(2R)Nipped-D341.1

(Rollins et al., 1999)

ct^2s has wing phenotype, enhanceable by Df(2R)Nipped-D263.3

(Rollins et al., 1999)

ct^2s has wing phenotype, enhanceable by Df(2R)Nipped-E299.1

(Rollins et al., 1999)

ct^2s has wing phenotype, enhanceable by Df(2R)Nipped-E43

(Rollins et al., 1999)

NOT Enhanced by

Statement

Reference

ct^2s has phenotype, non-enhanceable by brm[+]/brm²

(Krupp et al., 2005)

ct^2s has phenotype, non-enhanceable by Scer\GAL4^bbg-C96/brm^{K804R.UAS.Tag:HA}

(Krupp et al., 2005)

ct^2s has phenotype, non-enhanceable by mor[+]/mor¹

(Krupp et al., 2005)

Suppressed by

Statement

Reference

ct^2s has wing margin bristle phenotype, suppressible by Scer\GAL4^bbg-C96/BacA\p35^UAS.cHa

(Krupp et al., 2005)

ct^2s has wing blade phenotype, suppressible by Scer\GAL4^bbg-C96/BacA\p35^UAS.cHa

(Krupp et al., 2005)

ct^2s has phenotype, suppressible by Scer\GAL4^bbg-C96/lola^GS-A916

(Krupp et al., 2005)

NOT suppressed by

Statement

Reference

ct^2s has phenotype, non-suppressible by brm[+]/brm²

(Krupp et al., 2005)

ct^2s has phenotype, non-suppressible by Scer\GAL4^bbg-C96/brm^{K804R.UAS.Tag:HA}

(Krupp et al., 2005)

ct^2s has phenotype, non-suppressible by mor[+]/mor¹

(Krupp et al., 2005)

ct^2s has phenotype, non-suppressible by su(Hw)^unspecified

(Dorsett, 1993)

Other

Statement

Reference

Nipped-A^222.3, ct^2s has wing phenotype

(Rollins et al., 1999)

Nipped-B⁴, ct^2s has wing phenotype

(Rollins et al., 1999)

RpL38^45-72, ct^2s has wing phenotype

(Rollins et al., 1999)

Nipped-A^394.2, ct^2s has wing phenotype

(Rollins et al., 1999)

Nipped-B^292.1, ct^2s has wing phenotype

(Rollins et al., 1999)

Nipped-B^359.1, ct^2s has wing phenotype

(Rollins et al., 1999)

Nipped-B⁴⁰⁷, ct^2s has wing phenotype

(Rollins et al., 1999)

ct^2s, mam^g2.1 has wing phenotype

(Morcillo et al., 1996)

ct^2s, sd² has wing phenotype

(Morcillo et al., 1996)

ct^2s/ct[+], mam^g2.1 has wing phenotype

(Morcillo et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^C96 suppresses the loss of wing blade tissue, including the slender recurved chemosensory wing margin bristles, seen in ct^2s flies, but does not rescue the loss of the stout mechanosensory wing margin bristles.

(Krupp et al., 2005)

mam^g2.1; ct^2s and sd²; ct^2s double heterozygotes display a visible cut wing phenotype.

(Morcillo et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

ct^2s is partially rescued by Scer\GAL4^bbg-C96/ct^UAS.cPa

(Krupp et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ct^2s

(Rollins et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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