FlyBase Allele Report: Dmel\gro[E73]

General Information

Symbol

Dmel\gro^E73

Species

D. melanogaster

Name

FlyBase ID

FBal0031418

Feature type

allele

Associated gene

Dmel\gro

Associated Insertion(s)

Carried in Construct

Also Known As

E(spl)^E73

Key Links

Allele class

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Heitzler et al., 1996)

antimorphic allele - genetic evidence

(Delidakis et al., 1991)

hypomorphic allele - genetic evidence

(Coyle-Thompson and Banerjee, 1993)

Mutagen

ethyl methanesulfonate

(Preiss et al., 1988)

Progenitor genotype

E(spl)m8-HLH¹

(de Celis et al., 1991)

Cytology

Polytene chromosomes normal.

(Preiss et al., 1988)

Description

Point mutation.

(Delidakis et al., 1991, Xu et al., 1990)

Mutations in the m9/m10 coding region.

(de Celis et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

macrochaeta

(Barolo et al., 2002, Bang et al., 1995)

macrochaeta & scutum

(Heitzler et al., 1996)

microchaeta & scutum

(Heitzler et al., 1996)

sense organ & wing

(de Celis and Ruiz-Gomez, 1995)

wing blade anterior compartment

(de Celis and Ruiz-Gomez, 1995)

Detailed Description

Statement

Reference

Heterozygotes have a mild bristle loss phenotype.

(Barolo et al., 2002)

Clones fail to differentiate epidermis. Microchaetes are densely packed and adjacent to one another. Macrochaetes are present as dense tufts of abnormal bristles.

(Heitzler et al., 1996)

Clonal analysis revealed that the gro mutant bristle tufting phenotype is epistatic to the H null bristle loss phenotype.

(Bang et al., 1995)

In clones in the wing, the phenotype depends on where the clone lies. In the anterior compartment all clones abutting the wing margin cause local overgrowth and pattern duplications. Those abutting the wing margin and restricted to dorsal or ventral surfaces cause overgrowth of both dorsal and ventral cells. Clones at the wing margin cause loss of sensory organs and mild scalloping of the margin.

(de Celis and Ruiz-Gomez, 1995)

Heterozygotes that are also heterozygous for gro^BFP2 have eye defects that are similar but not identical to gro^BFP2 homozygotes. Homozygous mutant clones in the eye show ommatidial defects, often having extra photoreceptors.

(Fischer-Vize et al., 1992)

More than expected 25% of embryos from gro^E73/+ mothers die, revealing the dominant maternal effect.

(Delidakis et al., 1991)

Weak neurogenic phenotype.

(Preiss et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

H²¹, gro^E73/gro[+] has visible phenotype, non-enhanceable by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

NOT suppressed by

Statement

Reference

H²¹, gro^E73/gro[+] has visible phenotype, non-suppressible by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

Enhancer of

Statement

Reference

gro^E73/gro[+] is an enhancer of visible phenotype of Su(H)^RC-9Xm

(Barolo et al., 2002)

gro^E73/gro[+] is an enhancer of visible phenotype of H²¹

(Barolo et al., 2002)

gro^E73/gro[+] is an enhancer of visible | dominant phenotype of H^E31

(Barolo et al., 2002)

Suppressor of

Statement

Reference

gro^E73/gro[+] is a suppressor of visible | heat sensitive phenotype of N^l1N-ts1

(Barolo et al., 2002)

Other

Statement

Reference

gro^E73, sno^71e3 has lethal phenotype

(Coyle-Thompson and Banerjee, 1993)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

H²¹, gro^E73/gro[+] has macrochaeta phenotype, non-enhanceable by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

NOT suppressed by

Statement

Reference

H²¹, gro^E73/gro[+] has macrochaeta phenotype, non-suppressible by CtBP[+]/CtBP^87De-10

(Barolo et al., 2002)

Enhancer of

Statement

Reference

gro^E73/gro[+] is an enhancer of macrochaeta phenotype of Su(H)^RC-9Xm

(Barolo et al., 2002)

gro^E73/gro[+] is an enhancer of macrochaeta phenotype of H²¹

(Barolo et al., 2002)

gro^E73/gro[+] is an enhancer of macrochaeta phenotype of H^E31

(Barolo et al., 2002)

gro^E73/gro[+] is an enhancer of ocellar bristle phenotype of H^E31

(Barolo et al., 2002)

gro^E73/gro[+] is an enhancer of embryonic/first instar larval cuticle phenotype of eve¹

(Kobayashi et al., 2001)

Suppressor of

Statement

Reference

gro^E73/gro[+] is a suppressor of chaeta | heat sensitive phenotype of N^l1N-ts1

(Barolo et al., 2002)

Other

Statement

Reference

gro^E73, sno^71e3 has eye phenotype

(Coyle-Thompson and Banerjee, 1993)

N^nd-2, gro^E73 has wing phenotype

(Xu et al., 1990)

N^spl-1, gro^E73/gro[+] has wing vein L5 phenotype

(Xu et al., 1990)

Additional Comments

Genetic Interactions

Statement

Reference

gro^E73 dominantly enhances the bristle defects seen in H^E31/+ flies. Both the shaft-to-socket and bristle loss phenotypes are enhanced.

(Barolo et al., 2002)

The severity of cuticle defects seen in eve¹ embryos is increased if the mother is also heterozygous for gro^E73. The defects are pair rule in nature.

(Kobayashi et al., 2001)

Flies hemizygous for sno^71e3 and heterozygous for gro^E73 suffer lethality with a few escapers that show an eye roughening phenotype.

(Coyle-Thompson and Banerjee, 1993)

When heterozygous with N^nd-1 or N^nd-2 causes a severe wing material loss phenotype.

(Xu et al., 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Can be rescued by a gro^unspecified transgene.

(Preiss, 2000.2.18)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Preiss.

Comments

See Preiss et al., 1988, EMBO J. 7:3917--3927 .

(de Celis et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

E(spl)^E73

(Fischer-Vize et al., 1992, de Celis et al., 1991, Delidakis et al., 1991, Xu and Artavanis-Tsakonas, 1990, Xu et al., 1990, Preiss et al., 1988)

E(spl)^r19

(Price et al., 1997)

E⁷³

(Tata and Hartley, 1991)

gro^E73

Name Synonyms

Secondary FlyBase IDs

FBal0003340

References (18)

Report Sections

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