FlyBase Allele Report: Dmel\Cenp-C[prl41]

General Information

Symbol

Dmel\Cenp-C^prl41

Species

D. melanogaster

Name

FlyBase ID

FBal0031912

Feature type

allele

Associated gene

Dmel\Cenp-C

Associated Insertion(s)

Carried in Construct

Also Known As

l(3)85Aa^prl41, Cenp-C^pr141

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Heeger et al., 2005)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q1107term.

(Heeger et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:8,567,838..8,567,838 [+]

Nucleotide change:

C8567838T

Amino acid change:

Q1107term | Cenp-C-PA; Q1095term | Cenp-C-PB

Reported amino acid change:

Q1107term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Heeger et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death (with Df(3R)p25)

(Heeger et al., 2005)

lethal

lethal - all die during embryonic stage (with Df(3R)p25)

(Heeger et al., 2005)

lethal - all die during embryonic stage | recessive

(Heeger et al., 2005)

some die during embryonic stage (with Df(3R)p25)

(Heeger et al., 2005)

some die during embryonic stage | recessive

(Heeger et al., 2005)

Phenotype Manifest In

mitotic anaphase & nuclear chromosome

(Heeger et al., 2005)

mitotic telophase & nuclear chromosome

(Heeger et al., 2005)

presumptive embryonic/larval central nervous system (with Df(3R)p25)

(Heeger et al., 2005)

Detailed Description

Statement

Reference

Cenp-C^prl41/Df(3R)p25 animals show defects in the central nervous system (CNS) during the second half of embryogenesis; the CNS contains many oversize cells and has more apoptotic cells than normal. Mitosis 16 is severely abnormal in Cenp-C^prl41 embryos; while metaphase figures appear relatively normal, anaphase and telophase figures often have abnormal chromatin bridges.

(Heeger et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Cenp-C^prl41 has lethal | recessive phenotype, non-suppressible by CG11737^t15

(Heeger et al., 2005)

Cenp-C^prl41 has lethal | recessive phenotype, non-suppressible by CG31259^t15

(Heeger et al., 2005)

Cenp-C^prl41 has lethal | recessive phenotype, non-suppressible by pch2^t6.4

(Heeger et al., 2005)

Cenp-C^prl41 has lethal | recessive phenotype, non-suppressible by CG31454^t15

(Heeger et al., 2005)

Cenp-C^prl41 has lethal | recessive phenotype, non-suppressible by CG31460^t6.4

(Heeger et al., 2005)

Cenp-C^prl41 has lethal | recessive phenotype, non-suppressible by mRpS18C^t6.4

(Heeger et al., 2005)

Enhancer of

Statement

Reference

Cenp-C[+]/Cenp-C^prl41 is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, pim^UAS.Tag:MYC

(Heeger et al., 2005)

Cenp-C[+]/Cenp-C^prl41 is an enhancer of visible phenotype of thr^{ΔC.GMR.Tag:MYC}

(Heeger et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

Cenp-C[+]/Cenp-C^prl41 is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, pim^UAS.Tag:MYC

(Heeger et al., 2005)

Cenp-C[+]/Cenp-C^prl41 is an enhancer of eye phenotype of thr^{ΔC.GMR.Tag:MYC}

(Heeger et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cenp-C^prl41 is rescued by Cenp-C^+t8.7

(Heeger et al., 2005)

Cenp-C^prl41 is rescued by Cenp-C^+t14.6

(Heeger et al., 2005)

Partially rescued by

Cenp-C^prl41/Df(3R)p25 is partially rescued by Scer\GAL4^sca-537.4/Cenp-C^{ΔAT1.UAS.EGFP}

(Heeger et al., 2005)

Cenp-C^prl41/Df(3R)p25 is partially rescued by Scer\GAL4^sca-537.4/Cenp-C^FL.UAS.EGFP

(Heeger et al., 2005)

Not rescued by

Cenp-C^prl41 is not rescued by Cenp-C^abcd.m

(Heeger et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2814

kni^ri-1 rn^roe-1 Cenp-C^prl41 p^p/TM3, Sb¹

Kyoto

107470

kni^ri-1 rn^roe-1 Cenp-C^prl41 p^p/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Cenp-C^pr141

(Fellmeth et al., 2023, Hatkevich et al., 2019)

Cenp-C^prl41

(Raychaudhuri et al., 2012, Schittenhelm et al., 2010, Schittenhelm et al., 2009)

cenp-C^prl41

(Zhao et al., 2019)

l(3)85Aa^prl41

(Christensen et al., 2007.3.22, Gresens and Cook, 2006.8.29, Heeger et al., 2005, Jones and Rawls, 1988)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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