FlyBase Allele Report: Dmel\rho[Wk]

General Information

Symbol

Dmel\rho^Wk

Species

D. melanogaster

Name

Weak

FlyBase ID

FBal0035905

Feature type

allele

Associated gene

Dmel\rho

Associated Insertion(s)

P{HS-rho}Wk

Carried in Construct

Also Known As

rho^HS-Wk

Key Links

Allele class

gain of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

gain of function allele

(Sturtevant and Bier, 1995, Sturtevant et al., 1993)

Mutagen

P-element activity

(Sturtevant et al., 1993)

Progenitor genotype

rho^hs.PSt

(Sturtevant et al., 1993)

Associated Insertion(s)

P{HS-rho}Wk

Cytology

Description

rho gene expression is driven by an Hsp70 promoter.

(Sturtevant et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Baker et al., 2002, Guichard et al., 1999)

visible | dominant

(Sturtevant et al., 1993)

visible | recessive

(Baonza and Garcia-Bellido, 1999)

Phenotype Manifest In

wing vein

(Baonza and Garcia-Bellido, 1999, Guichard et al., 1999, Sturtevant et al., 1993)

wing vein | ectopic

(Baker et al., 2002)

Detailed Description

Statement

Reference

Flies carrying rho^Wk have ectopic veins in the wing (in the absence of heat shock).

(Baker et al., 2002)

rho^Wk/rho^Stg flies have extra wing veins.

(Baonza and Garcia-Bellido, 1999)

Whether heatshocked or not, this non-inducable line exhibits a very weak extra wing vein phenotype.

(Guichard et al., 1999)

In the absence of heat induction individuals display a very weak constitutive excess vein phenotype.

(Sturtevant et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

rho^Wk has visible phenotype, enhanceable by msk⁴

(Baker et al., 2002)

rho^Stg/rho^Wk has visible phenotype, enhanceable by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

rho^Wk has visible phenotype, enhanceable by S^hs.PK

(Guichard et al., 1999)

Suppressed by

Statement

Reference

rho^Stg/rho^Wk has visible phenotype, suppressible by emc^D/emc^D

(Baonza and Garcia-Bellido, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

rho^Wk has wing vein | ectopic phenotype, enhanceable by msk⁴

(Baker et al., 2002)

rho^Stg/rho^Wk has wing vein | ectopic phenotype, enhanceable by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

rho^Wk has wing phenotype, enhanceable by S^hs.PK

(Guichard et al., 1999)

rho^Wk has wing vein phenotype, enhanceable by S^hs.PK

(Guichard et al., 1999)

Suppressed by

Statement

Reference

rho^Stg/rho^Wk has wing vein | ectopic phenotype, suppressible by emc^D/emc^D

(Baonza and Garcia-Bellido, 1999)

NOT Enhancer of

Statement

Reference

Scer\GAL4^CY2/rho^Wk is a non-enhancer of wing vein | ectopic phenotype of btl::Egfr^λ.UAS

(Guichard et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The rho^Wk/rho^Stg extra wing vein phenotype is slightly enhanced by emc¹/emc¹¹ and slightly suppressed by emc^D/emc^D. Clones in the wing intervein regions that are doubly mutant for rho^Wk and emc¹ largely differentiate as veins.

(Baonza and Garcia-Bellido, 1999)

rho^Wk; S^hs.PK flies heatshocked between 6 and 9 hours after puparium formation (APF) show an extra vein phenotype much stronger than either rho^Wk or S^hs.PK alone. Entire intervein sectors are converted into veins. Flies heatshocked between 9 and 12 hours APF show a moderate extra vein phenotype, consisting of ectopic crossveins and additional longitudinal veins. Between 12 and 24 hours APF heatshocking induced diffuse extra vein material between wing veins L1 and L2, and between L4 and L5.

(Guichard et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Phenotype dependent on site of insertion of P{HS-rho} into the genome.

(Sturtevant et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

rho^HS-Wk

(Guichard et al., 1999, Sturtevant and Bier, 1995)

rho^Wk

ve^Wk

Name Synonyms

Weak

(Sturtevant et al., 1993)

Secondary FlyBase IDs

References (5)

Report Sections

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