FlyBase Allele Report: Dmel\zip[IIX62]

General Information

Symbol

Dmel\zip^IIX62

Species

D. melanogaster

Name

FlyBase ID

FBal0036091

Feature type

allele

Associated gene

Dmel\zip

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Young et al., 1993)

Mutagen

Progenitor genotype

Caused by aberration

Df(2R)gsb

Cytology

Description

Deficiency breakpoint within the zip locus.

(Young et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Young et al., 1993)

some die during embryonic stage

(Young et al., 1993)

Phenotype Manifest In

amnioserosa (with zip²)

(Franke et al., 2005)

embryo | dorsal closure stage (with zip²)

(Franke et al., 2005)

embryonic head

(Jacinto et al., 2002)

embryonic head (with zip¹)

(Jacinto et al., 2002)

embryonic leading edge cell

(Jacinto et al., 2002)

embryonic leading edge cell (with zip¹)

(Jacinto et al., 2002)

embryonic leading edge cell (with zip²)

(Franke et al., 2005)

epidermis | dorsal

(Young et al., 1993)

filamentous actin | dorsal closure stage (with zip²)

(Franke et al., 2005)

filopodium

(Jacinto et al., 2002)

filopodium (with zip¹)

(Jacinto et al., 2002)

Detailed Description

Statement

Reference

zip²/zip^IIX62 embryos show a dorsal closure phenotype with a low penetrance. Time-lapse imaging shows that in affected embryos there is a decrease in the rate of closure at end stages and the distribution of F-actin in leading-edge cells is disorganized as closure progresses. Additionally, there is a failure in the structural integrity of the amnioserosa, leading-edge cells, and the junction between them.

(Franke et al., 2005)

zip¹/zip^IIX62 embryos exhibit dramatic defects in head involution. 58% of zip¹/zip^IIX62 embryos have a clear dorsal hole (i.e.- dorsal closure is incomplete). The remaining embryos complete dorsal closure, although they frequently show puckering or segment misalignments along the closed midline seam. During dorsal closure the leading edge in zip¹/zip^IIX62 embryos is very disporganized and extends a broader extent of lamellipodial and filopodial protrusions per unit length of leading edge than wild-type.

(Jacinto et al., 2002)

Embryos fail to complete dorsal closure as the mutant myosin fails to contribute sufficient myosin to drive dorsal closure to completion.

(Young et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

zip^IIX62/zip[+] is an enhancer of visible phenotype of Scer\GAL4^hs.PB, tow^UAS.cCa

(Chung et al., 2007)

zip^IIX62 is an enhancer of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Suppressor of

Statement

Reference

zip^IIX62 is a suppressor of lethal | male phenotype of flw⁶

(Vereshchagina et al., 2004)

zip^IIX62 is a suppressor of lethal | male phenotype of flw^G0172

(Vereshchagina et al., 2004)

Other

Statement

Reference

rib¹, zip^IIX62 has viable phenotype

(Blake et al., 1998)

rib², zip^IIX62 has viable phenotype

(Blake et al., 1998)

Df(2R)P34, zip^IIX62 has viable phenotype

(Blake et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

zip^IIX62/zip[+] is an enhancer of wing hair | increased number phenotype of Scer\GAL4^hs.PB, tow^UAS.cCa

(Chung et al., 2007)

zip^IIX62 is an enhancer of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The multiple wing hair phenotype caused by expression of tow^Scer\UAS.cCa under the control of Scer\GAL4^hs.PB using heat shock at 24 hours after puparium formation is enhanced if the flies are also carrying one copy of zip^IIX62.

(Chung et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2528

Df(2R)gsb, cn¹ bw¹ zip^IIX62 gsb^IIX62/CyO

Kyoto

107384

y^* w^*; Df(2R)gsb, cn¹ bw¹ zip^IIX62 gsb^IIX62/SM1, speck²

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DfII62x

(Franke et al., 2005)

IIX62

(Kaltenbach et al., 2007)

zip^IIX62

(Chung et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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