FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dsor1Su34B
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General Information
Symbol
Dmel\Dsor1Su34B
Species
D. melanogaster
Name
FlyBase ID
FBal0039034
Feature type
allele
Associated gene
Dmel\Dsor1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lu et al., 1994)
Progenitor genotype
Cytology
Description

Amino acid replacement: D83V. Mutation is located 8 amino acids N terminal of the ATP binding motif.

(Lu et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:9,248,688..9,248,688 [+]
Nucleotide change:

A9248688T

Amino acid change:

D86V | Dsor1-PA; D83V | Dsor1-PB

Reported amino acid change:

D83V

Comment:

Reported as D83V in FBrf73777. Maps to D86V in the CDS encoded by the reference sequence. The difference is due to the use of an upstream splice acceptor in an upstream intron. The annotated version is supported by full length cDNA LD41207 (GB:AY058692). The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change.

(Lu et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Dsor1Su34B has phenotype, suppressible by Su(SuRaf1)IV4/Su(SuRaf1)IV[+]

      (Zhang et al., 1999)

      Dsor1Su34B has phenotype, suppressible by Egfr[+]/Egfr40-6

      (Zhang et al., 1999)

      Dsor1Su34B has phenotype, suppressible by Egfr[+]/Egfr30-1

      (Zhang et al., 1999)

      Dsor1Su34B has phenotype, suppressible by rl41-1/rl[+]

      (Zhang et al., 1999)

      Dsor1Su34B has phenotype, suppressible by cnksag13L/sag[+]

      (Zhang et al., 1999)

      Dsor1Su34B has phenotype, suppressible by sag[+]/cnksag32-3

      (Zhang et al., 1999)

      Dsor1Su34B has phenotype, suppressible by sag[+]/cnkA4-2

      (Zhang et al., 1999)

      Dsor1Su34B has phenotype, suppressible by Su(SuRaf1)IVA7-2/Su(SuRaf1)IV[+]

      (Zhang et al., 1999)
      NOT suppressed by
      Statement
      Reference

      Dsor1Su34B has phenotype, non-suppressible by cnk16-2/sag[+]

      (Zhang et al., 1999)

      Dsor1Su34B has phenotype, non-suppressible by Src42A[+]/Src42A15-1

      (Zhang et al., 1999)

      Dsor1Su34B has phenotype, non-suppressible by Src42A18-2/Src42A[+]

      (Zhang et al., 1999)
      Suppressor of
      Statement
      Reference

      Dsor1Su34B is a suppressor of eye phenotype of Raf1

      (Lu et al., 1994)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ability of Dsor1Su34B to suppress the lethality of phl1/Y flies is dominantly suppressed by Egfr40-6, Egfr30-1, rl41-1, sag13L, sag32-3, sagA4-2, Su(SuRaf1)IVA7-2 or Su(SuRaf1)IV4. The ability of Dsor1Su34B to suppress the lethality of phl1/Y flies is not suppressed by sag16-2, Src42A15-1 or Src42A18-2.

      (Zhang et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      phl1 homozygous lethality and hemizygous male eye defect can be partially rescued by one copy of Dsor1Su34B. Rescue is achieved by up-regulating phl signalling pathways. One copy will allow phl1 homozygous females to produce few eggs with two normal dorsal appendages.

      (Lu et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dsor1Su34B
      Su(D-raf)34B
      (Lu et al., 1994)
      Su(Raf)34B
      (Zhang et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)