FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\frc10098
Open Close
General Information
Symbol
Dmel\frc10098
Species
D. melanogaster
Name
FlyBase ID
FBal0043618
Feature type
allele
Associated gene
Dmel\frc
Associated Insertion(s)
P{PZ}frc10098
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Selva et al., 2001)
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}frc10098
Cytology
Description

P{PZ} insertion at nucleotide position 10 of the CG3874 gene prediction (which corresponds to frc), in the 5' untranslated region.

(Selva et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes die at the late pupal stage. Embryos derived from homozygous germline clones die during embryogenesis with strong segment polarity and mesodermal patterning defects that can be paternally rescued to viability.

      (Selva et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      frc[+]/frc10098 is an enhancer of visible | dominant phenotype of NAx-E2

      (Selva et al., 2001)
      Suppressor of
      Statement
      Reference

      frc10098 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

      (Maixner et al., 1998)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      frc[+]/frc10098 is an enhancer of wing vein phenotype of NAx-E2

      (Selva et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The penetrance of the loss of wing vein phenotype seen in NAx-E2/+ flies (8.7%) is enhanced to 95% by one copy of frc10098.

      (Selva et al., 2001)

      The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by frc10098.

      (Maixner et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      frc00073

      (BDGP Project Members, 1994-1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Excision of the P{PZ} element fully reverses the germ-line clone phenotype.

      (Selva et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      frc10098
      frcl(3)10098
      (Selva et al., 2001)
      l(3)0007310098
      (BDGP Project Members, 1994-1999)
      l(3)10098
      (Richardson, 2005.2.11, Maixner et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)