FlyBase Allele Report: Dmel\mxc[G46]

General Information

Symbol

Dmel\mxc^G46

Species

D. melanogaster

Name

FlyBase ID

FBal0046150

Feature type

allele

Associated gene

Dmel\mxc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Docquier et al., 1996)

Mutagen

ethyl methanesulfonate

(Santamaria and Randsholt, 1995)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q1643term.

(White et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:9,237,919..9,237,919 [-]

Nucleotide change:

C9237919T

Amino acid change:

Q1644term | mxc-PA; Q1644term | mxc-PB

Reported amino acid change:

Q1643term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(White et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of hematologic cancer

CEA

(Remillieux-Leschelle et al., 2002)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of hematologic cancer

is ameliorated by Tl^rv1

(Remillieux-Leschelle et al., 2002)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity | female

(Docquier et al., 1996)

decreased fecundity | female (with Df(1)10-70d)

(Docquier et al., 1996)

decreased fecundity | female (with mxc¹)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^16a-1)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^22a-6)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^G43)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^G48)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^SO)

(Docquier et al., 1996)

female sterile

(Remillieux-Leschelle et al., 2002)

female sterile | recessive

(Saget et al., 1998)

male sterile

(Remillieux-Leschelle et al., 2002)

male sterile | recessive

(Saget et al., 1998)

viable

(Remillieux-Leschelle et al., 2002, Docquier et al., 1996)

visible | homeotic

(Remillieux-Leschelle et al., 2002)

visible | recessive

(Santamaria and Randsholt, 1995)

Phenotype Manifest In

adult abdominal segment 4

(Santamaria and Randsholt, 1995)

dorsal appendage

(Docquier et al., 1996)

egg

(Docquier et al., 1996)

egg chamber

(Docquier et al., 1996)

egg chorion

(Docquier et al., 1996)

embryonic/larval lymph gland

(Remillieux-Leschelle et al., 2002)

eye

(Santamaria and Randsholt, 1995)

male accessory gland

(Docquier et al., 1996)

testis

(Docquier et al., 1996)

Detailed Description

Statement

Reference

Hemizygous larvae have overgrown lymph glands.

(Remillieux-Leschelle et al., 2002)

mxc^G9/mxc^G46 females have fewer egg chambers than wild-type flies, but are fully fertile and fecund. mxc^M1/mxc^G46 females lay many small eggs with a thin chorion and small dorsal appendages that collapse after oviposition. Homozygous females lay very few eggs. Some egg chambers contain the normal number of nurse cells, but oogenesis appears arrested before stage 7-8. Egg chambers degenerate in older flies. mxc^G46/mxc^SO, mxc^G46/mxc¹, mxc^G46/mxc^22a-6 and mxc^G46/mxc^16a-1 females do not lay eggs. Some egg chambers contain the normal number of nurse cells, but oogenesis appears arrested before stage 7-8. Egg chambers degenerate in older flies. mxc^G46/mxc^22a-6 females have reduced viability. mxc^G46/Df(1)10-70d and mxc^G46/mxc^G48 females have reduced viability, rudimentary gonads and do not lay eggs. The sheaths of the somatic cells that organise the ovarioles are still present and all structures derived from genital imaginal disc appear similar to wild-type. mxc^G46/mxc^G43 females have rudimentary gonads and do not lay eggs. The sheaths of the somatic cells that organise the ovarioles are still present and all structures derived from genital imaginal disc appear similar to wild-type. Hemizygous males have slightly shorter and thinner testes than wild-type. Sperm are usually immobile or absent, and paragonia are reduced compared to wild-type.

(Docquier et al., 1996)

Female heterozygotes with mxc¹ or mxc^SO are devoid of germ line. Adults show a low level of homeotic transformation. The eye transformation resembles that of Dfd¹.

(Santamaria and Randsholt, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Dfd¹, mxc^G46 has visible | dominant phenotype

(Saget et al., 1998)

Dfd¹, mxc^G46 has visible | recessive phenotype

(Saget et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

mxc[+]/mxc^G46 is an enhancer of leg | ectopic phenotype of hh^Mrt

(Randsholt et al., 2000)

mxc[+]/mxc^G46 is an enhancer of wing | anterior phenotype of hh^Mrt

(Randsholt et al., 2000)

Suppressor of

Statement

Reference

mxc^G46 is a suppressor of phenotype of z¹

(Santamaria and Randsholt, 1995)

Other

Statement

Reference

Dfd¹, mxc^G46 has adult head phenotype

(Saget et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

mxc^G46/Y Dfd¹/+ males have head defects.

(Saget et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32114

w¹ mxc^G46/FM7a

Notes on Origin

Discoverer

Comments

The alleles of mxc form a series. From weakest phenotype to strongest phenotype: mxc^G9 < mxc^M1 < mxc^G46 < mxc^G43 < mxc^SO < mxc¹ < mxc^G48.

(Santamaria and Randsholt, 1995)

Germline clonal analysis and pole cell transplantation indicates that mxc⁺ function is required autonomously in the female germline.

(Docquier et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mxc^G46

(Kurihara et al., 2020, Tatomer et al., 2016, Terzo et al., 2015, Landais et al., 2014, White et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (10)

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