FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\heca43
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General Information
Symbol
Dmel\heca43
Species
D. melanogaster
Name
FlyBase ID
FBal0049618
Feature type
allele
Associated gene
Dmel\heca
Associated Insertion(s)
Carried in Construct
Also Known As
hdc43
Key Links
Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Weaver and White, 1995)

loss of function allele

(Steneberg et al., 1998)
Mutagen
Delta2-3 transposase
(Weaver and White, 1995)
Progenitor genotype
hecaB5
(Weaver and White, 1995)
Cytology
Description

Imprecise excision of the P-element of hdcB5 and deletion of hdc coding region sequences.

(Weaver and White, 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      hdc43 homozygotes exhibit precocious differentiation of lamellocytes (within circulating hemocytes and in lymph gland) and a significant reduction in the ratio of plasmatocytes (within circulating hemocytes) while they do not exhibit any changes in the size of the lymph gland or the posterior signaling center when compared to control larvae.

      (Varga et al., 2019)

      R1/6/7 and cone cells differentiate precociously in clones that are mutant for hdc43, while the differentiation of R3/4 and R2/5 are unaffected.

      Adult hdc43 mutant eyes exhibit ommatidia with a normal structure but mis-rotation defects, in the anterior half of the eye, and ommatidia in the posterior half of the eye displaying missing photoreceptors, and elliptical and split rhabdomeres.

      Loss of hdc (in a hdc43 mutant) has no effect on photoreceptor proliferation or size.

      (Avet-Rochex et al., 2014)

      Defects in the dendrite severing which normally occurs during pruning are seen in 50% of homozygous single cell dendritic arborising sensory neuron C (ddaC) clones.

      Approximately 80% of homozygotes show severing defects in the dendrites of ddaC neurons at 18 hours after puparium formation (APF). Dendrite severing defects are also seen in the ddaD and ddaE neurons and in the dorsal bipolar dendrite (dbd) neurons.

      Development of gamma neurons derived from homozygous mushroom body neuron clones appears normal.

      (Loncle and Williams, 2012)

      All larval imaginal discs are present and their size and shape appear normal. The most prominent hdc defect involves head development and can result in the complete deletion of the head capsule or duplication of head cuticle or antenna. Pupae that survive to pharate adults exhibit massive defects in internal head structures, including the CNS, muscular and tracheal tissues. Wings, halteres, legs and epidermis are also affected.

      (Weaver and White, 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      EcRM554fs, hdc[+]/heca43 has abnormal neuroanatomy | pupal stage phenotype

      (Loncle and Williams, 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      EcRM554fs/+ in heterozygous combination with hdc43 results in defects in pruning of the ddaC dorsal dendritic arborising neurons: dendrites are still seen attached to the cell body at 18 hours after puparium formation (9%).

      (Loncle and Williams, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      heca43 is rescued by Scer\GAL4kn-col85-GAL4/hecaUAS.cSa

      (Varga et al., 2019)

      heca43 is rescued by hecaUAS.cSa/Scer\GAL4ppk.1.9

      (Loncle and Williams, 2012)

      heca43 is rescued by hecahs.PW

      (Weaver and White, 1995)
      Partially rescued by

      heca43 is partially rescued by hecas.UAS.Tag:FLAG/Scer\GAL4ppk.1.9

      (Loncle and Williams, 2012)
      Comments

      Expression of hdcScer\UAS.cSa under the control of Scer\GAL4ppk.1.9 rescues the defects in dendrite severing which are seen in the ddaC neurons of hdc43 homozygous pupae.

      Expression of hdcs.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4ppk.1.9 partially rescues the defects in dendrite severing which are seen in the ddaC neurons of hdc43 homozygous pupae.

      (Loncle and Williams, 2012)

      Pupal lethality can be completely rescued by hdchs.PW.

      (Weaver and White, 1995)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hdc43
      (Ren et al., 2022, Maierbrugger et al., 2020, Varga et al., 2019, Avet-Rochex et al., 2014, Resende et al., 2013, Loncle and Williams, 2012)
      heca43
      Name Synonyms
      Secondary FlyBase IDs
        References (8)