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General Information
Symbol
Dmel\cher1
Species
D. melanogaster
Name
FlyBase ID
FBal0060473
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    In cher1 mutants, egg chamber ring canals lack the robust F-actin cytoskeleton found in wild type controls.

    cher1 heterozygotes do not exhibit a significant change in the number of recognizable sarcomeres in adult indirect flight muscles, as compared to controls. cher1/Df(3R)Exel6176 transheterozygotes exhibit widening of Z-discs at the adult indirect flight muscle sarcomeres, as compared to controls.

    cher1 homozygous embryos display increased frequency of defasciculation defects in axons of the intersegmental nerve b, segmental nerve as well as intersegmental nerve (no obvious defects in the morphology and development of ventrolateral muscles are observed).

    Removing cher, through inducing cher1 mitotic clones within the developing eye-antennal imaginal disc, has no impact on clone number or morphology and results in adults with regular eyes.

    Homozygous embryos show defects in the guidance of the intersegmental nerve in the periphery.

    Homozygous larvae have lamellocytes in the circulation without any immune challenge (in contrast to wild-type controls). The number of these cells in the circulation is further increased following infestation with a parasitoid wasp.

    chersko/cher1 females are sterile and have defects in ring canal assembly and egg chamber morphology.

    Egg chambers of homozygous females have impaired cytoplasm transport from nurse cell to oocyte. The egg chamber phenotype of cher1 homozygotes is less severe than that of cher1 homozygotes. Homozygous egg chambers lack the actin inner rim of the ring canals, although subcortical actin appears normal. The fusomes ares normal in the early germaria and develop into normal branched polyfusomes.

    Defective in cytoplasm transport.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    cher1, Act88F6 double heterozygotes frequently present myofibrils that are too frayed to distinguish individual sarcomeres, as compared to the corresponding single heterozygous controls.

    Loss of cher markedly interferes with the growth of Ras85DV12.Scer\UAS scrib1 tumours. The loss of cher does not affect the level of apoptosis in either the clonal nor the surrounding eye-antennal imaginal disc, indicating that loss of cher does not affect tumour cell viability.

    Eye-antennal imaginal discs carrying Ras85DV12.Scer\UAS scrib1 cher1 clones display extra cell divisions, mainly occurring in the surrounding non-clonal tissue.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Fails to complement
    Rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    References (14)