FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\htsk06121
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General Information
Symbol
Dmel\htsk06121
Species
D. melanogaster
Name
FlyBase ID
FBal0064449
Feature type
allele
Associated gene
Dmel\hts
Associated Insertion(s)
P{lacW}htsk06121
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}htsk06121
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTT128Q.1-336.UAS
      (Kaltenbach et al., 2007)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      centrosome & spermatocyte (with Df(2R)BSC26)

      (Wilson, 2005)

      fusome & testis (with Df(2R)BSC26)

      (Wilson, 2005)

      germ cell & egg chamber (with Df(2R)BSC26)

      (Wilson, 2005)

      spindle & spermatocyte (with Df(2R)BSC26)

      (Wilson, 2005)
      Detailed Description
      Statement
      Reference

      Many egg chambers from htsk06121/Df(2R)BSC26 frequently lack a full complement of germ cells.

      Gonial cells of htsk06121/Df(2R)BSC26 testes show branched fusome structures and presumptive ring canals by immunostaining of Klp61F, although fusome branches appear thinner and frequently broken.

      In contrast to wild type, several spermatocytes in htsk06121/Df(2R)BSC26 mutants contain too many or too few centrosomes.

      In contrast to wild type, 11% of meiotic spermatocytes in htsk06121/Df(2R)BSC26 mutant testes show spindle abnormalities, including monopolar and multipolar spindles.

      (Wilson, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      htsk06121 is a suppressor of visible phenotype of Hsap\HTT128Q.1-336.UAS, Scer\GAL4GMR.PU

      (Kaltenbach et al., 2007)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      htsk06121 is a suppressor of eye phenotype of Hsap\HTT128Q.1-336.UAS, Scer\GAL4GMR.PU

      (Kaltenbach et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)
      Comments
      Comments

      Complements: l(2)k00705k00705. Complements: l(2)k00705k00806. Complements: par-1k06323. Complements: l(2)k16207k16207. Complements: RpL11k16914.

      (BDGP Project Members, 1994-1999)

      Based on fusome assembly and immunoblot analysis, hts mutants can be placed in an allelic series from the most to the least severe: hts01103 > hts1 > htsKG06777 > htsk06121.

      (Wilson, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      fs(2)k06121
      (Beaton, 1999.12.12)
      htsK06121
      (Wilson, 2005)
      htsk06121
      (Saha et al., 2023, Grice et al., 2015, Wilson, 2005)
      k06121
      (Kaltenbach et al., 2007)
      l(2)k06121
      (Palmer et al., 1999)
      l(2)k06121k06121
      (BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)