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General Information
Symbol
Dmel\ttk88.GMR.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0082129
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-ttk88
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

GMR regulatory sequences drive expression the ttk TTK88 protein isoform, tagged at the C-terminal end with a Tag:MYC epitope.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

All adult ttk88.GMR.T:Hsap\MYC/+ flies are devoid of photoreceptors. Cell death is elevated in late third instar eye discs for strong ttk88.GMR.T:Hsap\MYC lines. 88% of ttk88.GMR.T:Hsap\MYC/+ ommatidia lack 1-3 cone cells, while only 4% contain 1-2 supernumerary cone cells.

Photoreceptor cell determination is blocked.

Flies carrying ttk88.GMR.T:Hsap\MYC have a rough eye phenotype.

Flies carrying ttk88.GMR.T:Hsap\MYC have rough eyes that are devoid of photoreceptors. Third larval instar eye imaginal discs carrying ttk88.GMR.T:Hsap\MYC show increased cell death compared to wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Suppressor of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

ttk88.GMR.Tag:MYC is a suppressor of eye phenotype of phylGMR.PC

Additional Comments
Genetic Interactions
Statement
Reference

Ectopic expression of both svGMR.PS and ttk88.GMR.T:Hsap\MYC generates supernumerary cone cells in about 90% of the ommatidia of pupal eye discs, with a maximum of 11 cone cells observed in one ommatidium.

More than half of the ommatidia in svGMR.PS ttk88.GMR.T:Hsap\MYC eyes have two or three supernumerary cone cells: 30% have three, 24% have two, and 14% have one supernumerary cone cell.

The addition of svGMR.PS results in less photoreceptor cell death in ttk88.GMR.T:Hsap\MYC third instar eye discs.

Flies carrying both phylGMR.PC and ttk88.GMR.T:Hsap\MYC have nearly wild-type eyes, with most of the ommatidia having close to the normal number of photoreceptor cells. sina2/sina3 flies carrying both phylGMR.PC and ttk88.GMR.T:Hsap\MYC have very disrupted eyes, similar to those of flies carrying ttk88.GMR.T:Hsap\MYC alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
ttk88.GMR.T:Hsap\MYC
ttk88.GMR.T:Myc
ttk88.GMR.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (4)