FlyBase Allele Report: Dmel\slmb[00295]

(Zhang et al., 2015, Roberts et al., 2012, Kuo et al., 2006, Muzzopappa and Wappner, 2005, Watts et al., 2003, Noureddine et al., 2002, Spradling et al., 1999, Jiang and Struhl, 1998, Theodosiou et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates nervous system disease

modeled by Atpα^CJ10

(Talsma et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Kuo et al., 2006)

increased cell death

(Kuo et al., 2006)

lethal

(Jiang and Struhl, 1998)

lethal | recessive

(Spradling et al., 1999)

lethal - all die before end of pupal stage

(Kuo et al., 2006)

lethal - all die during embryonic stage | recessive

(Theodosiou et al., 1998)

some die during embryonic stage | recessive

(Theodosiou et al., 1998)

some die during pupal stage

(Kuo et al., 2006)

Phenotype Manifest In

haltere

(Jiang and Struhl, 1998)

leg

(Theodosiou et al., 1998)

leg disc

(Theodosiou et al., 1998)

macrochaeta & wing margin

(Jiang and Struhl, 1998)

macrochaeta | ectopic

(Jiang and Struhl, 1998)

wing

(Theodosiou et al., 1998)

wing disc

(Theodosiou et al., 1998)

Detailed Description

Statement

Reference

slmb⁰⁰²⁹⁵ mutant C4da neuron clones exhibit an increase in cell death and die during early metamorphosis.

(Kuo et al., 2006)

No defects are seen in axon pruning during metamorphosis.

(Watts et al., 2003)

Homozygotes carrying a single copy of slmb^αTub84B.PJ are viable and show normal morphology, 5-10% of adults exhibit duplication of the haltere. Mutant cells undergo only a few divisions and show phenotypes characteristic of ectopic wg and hh signal transduction. Clones in the wing cause generation of ectopic sensory bristles along the wing margin, instead of epidermal hairs. Heterozygotes with slmb¹ die as pupae and heterozygotes with slmb² die during early larval life.

(Jiang and Struhl, 1998)

Clones of mutant cells in the leg and wing discs cause outgrowths of slmb⁺ cells and pattern disruptions including duplicated structures. Outgrowths occur both ventrally and dorsally and both anteriorly and posteriorly.

(Theodosiou et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ago³, slmb⁰⁰²⁹⁵ has increased cell number | embryonic stage phenotype, suppressible by slmb^{αTub84B.Tag:MYC}

(Ho et al., 2009)

ago³, slmb⁰⁰²⁹⁵ has increased cell number | embryonic stage phenotype, suppressible by gcm^N7-4/gcm[+]

(Ho et al., 2009)

ago³, slmb⁰⁰²⁹⁵ has increased cell number | embryonic stage phenotype, suppressible by gcm²⁶

(Ho et al., 2009)

Other

Statement

Reference

ago³, slmb⁰⁰²⁹⁵ has increased occurrence of cell division | embryonic stage phenotype

(Ho et al., 2009)

ago³, slmb⁰⁰²⁹⁵ has increased cell number | embryonic stage phenotype

(Ho et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

ago³, slmb⁰⁰²⁹⁵ has glial cell | embryonic stage phenotype, suppressible by slmb^{αTub84B.Tag:MYC}

(Ho et al., 2009)

ago³, slmb⁰⁰²⁹⁵ has glial cell | embryonic stage phenotype, suppressible by gcm^N7-4/gcm[+]

(Ho et al., 2009)

ago³, slmb⁰⁰²⁹⁵ has glial cell | embryonic stage phenotype, suppressible by gcm²⁶

(Ho et al., 2009)

Other

Statement

Reference

ago³, slmb⁰⁰²⁹⁵ has glial cell | embryonic stage phenotype

(Ho et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

slmb⁰⁰²⁹⁵, ago³ double mutant embryos display a disrupted glial pattern compared to single mutant or control embryos. An increase in repo-positive glial cell number is observed. An increase in cell proliferation is observed, and no increase in cell death is seen.

Expression of slmb^{αTub84B.T:Hsap\MYC} in slmb⁰⁰²⁹⁵, ago³ double mutant embryos significantly suppresses the increased number of glial cells observed in the slmb⁰⁰²⁹⁵, ago³ mutant embryos.

slmb⁰⁰²⁹⁵, ago³, gcm^N7-4 triple mutants results in the absence of almost all glia, as observed in gcm^N7-4 single mutants. One copy of gcm^N7-4 suppresses the increased glial cell number phenotype observed in slmb⁰⁰²⁹⁵, ago³ double mutants.

gcm²⁶ suppresses the increased glial cell number phenotype observed in slmb⁰⁰²⁹⁵, ago³ double mutants.

(Ho et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

slmb^8A6-5

(Morais-de-Sá et al., 2014)

slmb^9H4-17

(Morais-de-Sá et al., 2014)

slmb⁰⁵⁴¹⁵

(BDGP Project Members, 1994-1999)

slmb⁰⁴²⁹⁵

(BDGP Project Members, 1994-1999)

Rescued by

slmb⁰⁰²⁹⁵ is rescued by slmb^αTub84B.PJ

(Jiang and Struhl, 1998)

slmb⁰⁰²⁹⁵ is rescued by slmb^hs.PT

(Theodosiou et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11493

ry⁵⁰⁶ P{PZ}slmb⁰⁰²⁹⁵/TM3, ry^RK Sb¹ Ser¹

Kyoto

108870

ry⁵⁰⁶ P{PZ}slmb⁰⁰²⁹⁵/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Previously assigned as an allele of Atpα in FlyBase (in error). Now known to be an allele of slmb, based on the insertion of the P{PZ} element within the slmb transcription unit, reversion of the mutant phenotype by precise excision of the P{PZ} insertion and rescue of the mutant phenotype by a transgene containing the slmb coding region (see FBrf0100581 and FBrf0104785).

Wild type slmb function can be restored by precise excision of the P{PZ} insertion.

(Jiang and Struhl, 1998)

Complements: Atpα^01453a. Complements: ppan⁰²²³¹. Complements: Atpα⁰⁷⁰⁰⁸. Complements: rtet⁰⁷⁰⁸⁶. Complements: Atpα⁰⁷⁰⁹⁷. Complements: ppan^j6B6. Complements: l(3)neo54¹.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

00295

(Watts et al., 2003)

Atpα⁰⁰²⁹⁵

Slmb²⁹⁵

(Talsma et al., 2014)

l(3)00295

(Spradling et al., 1999, Jiang and Struhl, 1998)

slimb⁰⁰²⁹⁵

(Khire et al., 2015)

slimb^P1493

(Ho et al., 2009, Takacs et al., 2008, Noureddine et al., 2002)

slimb^P

(Ou et al., 2002, Wang et al., 1999)

slmb⁰⁰²⁹⁵

(Collu et al., 2018, Ricolo et al., 2016, Morais-de-Sá et al., 2014, Abdou et al., 2011, Christensen et al., 2008.4.15, Silva et al., 2007)

slmb^P1493

(Zhang et al., 2015)

slmb^PZ00295

(Theodosiou et al., 1998)

Name Synonyms

Secondary FlyBase IDs

FBal0000794

References (24)

Report Sections

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