FlyBase Allele Report: Dmel\gcm[26]

General Information

Symbol

Dmel\gcm²⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0049595

Feature type

allele

Associated gene

Dmel\gcm

Associated Insertion(s)

Carried in Construct

Also Known As

glide²⁶, glide/gcm²⁶

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Bernardoni et al., 1997)

Mutagen

Delta2-3 transposase

(Vincent et al., 1996)

Progenitor genotype

gcm^rA87

(Bernardoni et al., 1997, Vincent et al., 1996)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Kammerer and Giangrande, 2001)

lethal | recessive

(Vincent et al., 1996)

lethal - all die during embryonic stage | recessive

(Jacques et al., 2009)

some die during embryonic stage | recessive

(Jacques et al., 2009)

Phenotype Manifest In

CNS glial cell

(De Iaco et al., 2006, Kammerer and Giangrande, 2001)

larval glial cell

(Vincent et al., 1996)

larval longitudinal connective

(Kammerer and Giangrande, 2001)

larval longitudinal connective | embryonic stage

(Vincent et al., 1996)

nerve | embryonic stage

(Vincent et al., 1996)

Detailed Description

Statement

Reference

gcm^rA87.P/gcm²⁶ larvae do not have melanotic tumours.

(Jacques et al., 2009)

Glia are absent from the ventral cord of gcm²⁶ mutant embryos.

(De Iaco et al., 2006)

Lateral glial cells of the embryonic central nervous system are almost entirely absent. Longitudinal connective shows breaks in stage 15 embryos.

(Kammerer and Giangrande, 2001)

Homozygous embryos exhibit a drastic reduction in the number of glial cells. Longitudinal fibres are partially or completely interrupted in several segments and the peripheral nerves exhibit defects.

(Vincent et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

gcm²⁶ is an enhancer of melanotic mass phenotype | larval stage | dominant phenotype of Tl^10b

(Bazzi et al., 2023)

gcm²⁶ is an enhancer of increased cell number | larval stage | dominant phenotype of Tl^10b

(Bazzi et al., 2023)

Suppressor of

Statement

Reference

gcm²⁶ is a suppressor of increased cell number | embryonic stage phenotype of ago³, slmb⁰⁰²⁹⁵

(Ho et al., 2009)

Other

Statement

Reference

Su(var)2-10¹, gcm²⁶/gcm^rA87.P has melanotic mass phenotype phenotype

(Jacques et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

gcm²⁶ is an enhancer of embryonic/larval hemocyte | larval stage | increased number phenotype of Tl^10b

(Bazzi et al., 2023)

gcm²⁶ is an enhancer of lamellocyte | larval stage | increased number phenotype of Tl^10b

(Bazzi et al., 2023)

Suppressor of

Statement

Reference

gcm²⁶ is a suppressor of glial cell | embryonic stage phenotype of ago³, slmb⁰⁰²⁹⁵

(Ho et al., 2009)

Other

Statement

Reference

Su(var)2-10¹, gcm²⁶/gcm^rA87.P has melanotic mass phenotype

(Jacques et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

gcm²⁶ suppresses the increased glial cell number phenotype observed in slmb⁰⁰²⁹⁵, ago³ double mutants.

(Ho et al., 2009)

gcm^rA87.P Su(var)2-10¹/gcm²⁶ larvae have a melanotic tumour phenotype.

(Jacques et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

gcm²⁶/Df(2L)132 is rescued by gcm^+t36.5

(Laneve et al., 2013)

gcm²⁶/Df(2L)132 is rescued by gcm^Tag:FLAG

(Laneve et al., 2013)

gcm²⁶ is rescued by gcm^+t36.5

(Laneve et al., 2013)

gcm²⁶ is rescued by gcm^Tag:FLAG

(Laneve et al., 2013)

gcm²⁶ is rescued by gcm^+t5.6

(De Iaco et al., 2006)

gcm²⁶ is rescued by gcm^2kbΔHBS

(De Iaco et al., 2006)

Not rescued by

gcm²⁶ is not rescued by gcm^2kbΔGBSI

(De Iaco et al., 2006)

Comments

gcm^+t36.5 and gcm^T:Zzzz\FLAG each fully rescue the lethality of gcm²⁶/gcm²⁶ and gcm²⁶/Df(2L)132 animals.

(Laneve et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

gcm²⁶

(Bazzi et al., 2023, Laneve et al., 2013, Ho et al., 2009, Jacques et al., 2009, Soustelle et al., 2008)

glide/gcm²⁶

(Kammerer and Giangrande, 2001, Bernardoni et al., 1997)

glide²⁶

(Ragone et al., 2003, Vincent et al., 1996)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

Open Close