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General Information
Symbol
Dmel\Su(var)2-101
Species
D. melanogaster
Name
FlyBase ID
FBal0123988
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dpias1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T9118289A

Reported nucleotide change:

T?A

Amino acid change:

L327M | Su(var)2-10-PA; L327M | Su(var)2-10-PB; L338M | Su(var)2-10-PC; L374M | Su(var)2-10-PD; L327M | Su(var)2-10-PE; L338M | Su(var)2-10-PF; L338M | Su(var)2-10-PG; L374M | Su(var)2-10-PH; L374M | Su(var)2-10-PI; L327M | Su(var)2-10-PJ; L338M | Su(var)2-10-PK; L374M | Su(var)2-10-PL; L374M | Su(var)2-10-PM; L374M | Su(var)2-10-PN

Reported amino acid change:

L327M

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: T?A. Amino acid replacement: L327M.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

interphase & nuclear chromosome (with Su(var)2-102)

Detailed Description
Statement
Reference

Su(var)2-101/Su(var)2-102 mutants exhibit significant genome instability in larval neuroblasts (in the absence of ionizing radiation), including aneuploidy, chromosome fusions and changes in the number of satellites.

Heterozygotes show an increase in crossing over between kni and pp. Heterozygotes show an increase in crossing over between se and kni, between kni and ss and between e and ro. Heterozygotes show a decrease in crossing over between y and N. Heterozygous females show reduced disjunction and/or chromosome loss in oogenesis compared to controls.

Causes dominant zygotic and maternal reductions in the transmission of Dp(1;f)J21A to offspring. A weak but reproducible decrease in transmission is seen when Su(var)2-101 is inherited from the father. When inherited from heterozygous mothers, zygotic and maternal defects combined to reduce Dp(1;f)J21A transmission levels to 7%. Su(var)2-101/Su(var)2-102 transheterozygous animals die as late larvae or early pupae, 3-15% of larvae have melanotic tumours. The penetrance of these tumours is temperature sensitive. The structure and function of chromosomes in Su(var)2-101/Su(var)2-102 mutants are grossly abnormal in both males and females. Two major types of chromosome defects are observed: abnormally condensed chromosomes in metaphase and aberrantly segregating chromosomes in anaphase. Anaphase segregation defects include chromosome fragmentation and bridging. Penetrance of the metaphase defects are temperature sensitive. Salivary glands in Su(var)2-101/Su(var)2-102 mutants are reduced in size, and the consistent banding pattern of normal polytene chromosomes is severely disrupted. They are generally disorganised and abnormally condensed. In Su(var)2-101/Su(var)2-102 third instar larvae, interphase chromosome organisation is altered. telomere-telomere and telomere-lamina associations are disrupted in mutant nuclei.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference

Su(var)2-101 is a non-suppressor of eye phenotype of HersUAS.Tag:FLAG, Scer\GAL4GMR.PU

Other
Additional Comments
Genetic Interactions
Statement
Reference

The Scer\GAL4GMR.PU, HersScer\UAS.T:Zzzz\FLAG rough eye phenotype is not modified by Su(var)2-101.

gcmrA87.P Su(var)2-101 double heterozygous larvae do not have melanotic tumours.

gcmrA87.P Su(var)2-101/gcm26 larvae have a melanotic tumour phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)