gcmrA87.P heterozygotes do not show significant differences in the number of eggs laid, as compared to controls; gcmrA87.P/gcmrA87 transheterozygous females present significant reductions in the numbers of progeny and of eggs laid, as compared to controls; gcmrA87.P homozygous females are nearly sterile and lay virtually no eggs; gcmrA87.P heterozygous females and gcmrA87.P/gcmrA87 transheterozygous males are fertile.
Unlike controls, the spermathecae of gcmrA87.P homozygous females exhibit a significant increase in the number of lumen epithelial cells, exhibit a complete lack of secretory cells, and do not accumulate spermatozoids after copulation, but the inner cuticular structure is apparently intact; most spermathecae of gcmrA87.P/gcmrA87 transheterozygous females exhibit a complete lack of secretory cells, although a few secretory cells remain in some cases.
Homozygous flies show glia to neuron transformation in the L3-v lineage in the wing.
Homozygous escapers show loss of the "cup-like" clusters of glia which are normally present in each thoracic hemineuromere (the leg neuropile glia). The phenotype is variable, with one to four clusters being missing. However, within a given cluster, partial loss of glia is not seen, such that the whole population of a given cluster is either present or absent. Other glial lineages are unaltered in the escapers and there are no defects in the gcm-positive neurons of the ventral nerve cord.
gcmrA87.P/Df(2L)132 results in complete lethality and the animals show glial differentiation defects in the embryo.