FlyBase Gene Report: Dmel\Su(var)2-10

General Information

Symbol

Dmel\Su(var)2-10

Species

D. melanogaster

Name

Suppressor of variegation 2-10

Annotation Symbol

CG8068

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003612

Gene Model Status

Current

Stock Availability

27 publicly available

Gene Summary

Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

dPIAS, PIAS, zimp, Sv210, l(2)03697

Key Links

Genomic Location

Cytogenetic map

45A8-45A9

Sequence location

2R:9,116,122..9,122,000 [+]

Recombination map

2-60

RefSeq locus

NT_033778 REGION:9116122..9122000

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (24 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables STAT family protein binding

inferred from physical interaction with UniProtKB:Q24151

(Betz et al., 2001)

enables SUMO ligase activity

inferred from mutant phenotype

(Tang et al., 2021)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables SUMO ligase activity

inferred from biological aspect of ancestor with PANTHER:PTN000081660

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:O75925

(Gene Ontology Curators, 2002-)

enables transcription coregulator activity

inferred from biological aspect of ancestor with PANTHER:PTN000081660

(GO Reference Genome Project, 2011-)

enables transcription regulator inhibitor activity

inferred from biological aspect of ancestor with PANTHER:PTN000845825

(GO Reference Genome Project, 2011-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR004181

(InterPro Project Members, 2004-)

Biological Process (13 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

involved_in chromosome condensation

inferred from mutant phenotype

(Hari et al., 2001)

involved_in chromosome organization

inferred from mutant phenotype

(Hari et al., 2001)

involved_in compound eye development

inferred from mutant phenotype

(Betz et al., 2001)

involved_in defense response to Gram-negative bacterium

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

involved_in negative regulation of peptidoglycan recognition protein signaling pathway

inferred from mutant phenotype

(Tang et al., 2021)

involved_in negative regulation of receptor signaling pathway via JAK-STAT

inferred from genetic interaction with FLYBASE:Stat92E; FB:FBgn0016917

(Betz et al., 2001)

inferred from direct assay

(Muller et al., 2005)

involved_in positive regulation of innate immune response

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

involved_in positive regulation of smoothened signaling pathway

inferred from mutant phenotype

(Zhang et al., 2017)

inferred from genetic interaction with FLYBASE:smo; FB:FBgn0003444

(Ma et al., 2016)

involved_in positive regulation of somatic stem cell division

inferred from mutant phenotype

(Lv et al., 2016)

involved_in protein sumoylation

inferred from mutant phenotype

(Tang et al., 2021)

inferred from direct assay

(Ma et al., 2016)

involved_in transposable element silencing by piRNA-mediated heterochromatin formation

inferred from physical interaction with FLYBASE:piwi; FB:FBgn0004872

(Bence et al., 2024)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

involved_in chromosome organization

traceable author statement

(Luo and Dearolf, 2001)

involved_in compound eye development

traceable author statement

(Luo and Dearolf, 2001)

involved_in imaginal disc growth

traceable author statement

(Luo and Dearolf, 2001)

involved_in negative regulation of receptor signaling pathway via JAK-STAT

inferred from biological aspect of ancestor with PANTHER:PTN000845825

(GO Reference Genome Project, 2011-)

involved_in protein sumoylation

inferred from sequence or structural similarity with UniProtKB:O75925

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000081660

(GO Reference Genome Project, 2011-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001324782

(GO Reference Genome Project, 2011-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in chromosome, telomeric region

inferred from direct assay

(Hari et al., 2001)

located_in cytoplasm

inferred from direct assay

(Hari et al., 2001)

located_in nuclear lamina

inferred from direct assay

(Hari et al., 2001)

located_in nucleoplasm

inferred from direct assay

(Hari et al., 2001)

located_in nucleus

inferred from direct assay

(Hari et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in chromatin

inferred from biological aspect of ancestor with PANTHER:PTN000081660

(GO Reference Genome Project, 2011-)

is_active_in nucleoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000081660

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SUMO TRANSFERASES

Pathway (FlyBase)

NEGATIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY

POSITIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY

NEGATIVE REGULATORS OF IMD SIGNALING PATHWAY

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pathway (FlyBase)

NEGATIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY -: Negative regulators of JAK-STAT signaling down-regulate the pathway, attenuating transcriptional control by Stat92E.
POSITIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY -: Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
NEGATIVE REGULATORS OF IMD SIGNALING PATHWAY -: Negative regulators of the immune deficiency (Imd) pathway result in the decreased activity of the NFκB-like transcription factor Rel in the nucleus. Negative regulators are important in preventing damage to the host from over-activation of the pathway; preventing inappropriate triggering or terminating the response. (Adapted from FBrf0224587 and FBrf0238555.)

Gene Group (FlyBase)

SUMO TRANSFERASES -: SUMO transferases catalyze the transfer of SUMO from either E2 or E3 enzyme to a substrate.

Summary (Interactive Fly)

SUMO E3 ligase - promotes the efficiency of SUMOylation - links the piRNA-guided target recognition complex to the silencing effector by binding the piRNA/Piwi complex and inducing SUMO-dependent recruitment of the SetDB1 (Eggless)/Wde histone methyltransferase effector - chromatin modification

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Su(var)2-10 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A1Z7P5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Su(var)2-10-RA

FBtr0088578

NM_078940

2063

554

Su(var)2-10-RB

FBtr0088577

NM_165651

2306

593

Su(var)2-10-RC

FBtr0088573

NM_165649

2389

565

Su(var)2-10-RD

FBtr0088572

NM_165646

2159

601

Su(var)2-10-RE

FBtr0088576

NM_165652

2847

522

Su(var)2-10-RF

FBtr0088574

NM_165650

2548

533

Su(var)2-10-RG

FBtr0088575

NM_165648

2632

604

Su(var)2-10-RH

FBtr0088571

NM_165647

2943

569

Su(var)2-10-RI

FBtr0088570

NM_165645

2402

640

Su(var)2-10-RJ

FBtr0302505

NM_001201957

2054

537

Su(var)2-10-RK

FBtr0302506

NM_001201958

2632

537

Su(var)2-10-RL

FBtr0302507

NM_001201959

2150

584

Su(var)2-10-RM

FBtr0306705

NM_001259286

2149

570

Su(var)2-10-RN

FBtr0343996

NM_001299299

2414

577

Additional Transcript Data and Comments

Reported size (kB)

4.4, 2.8, 2.2 (northern blot)

(Mohr and Boswell, 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Su(var)2-10-PA

FBpp0087659

61.7

554

8.88

FBpp0087658

65.2

593

7.00

FBpp0087654

63.0

565

8.61

FBpp0087653

66.8

601

9.00

FBpp0087657

57.9

522

7.79

FBpp0087655

59.2

533

7.32

FBpp0087656

66.5

604

6.66

FBpp0087652

63.0

569

8.07

FBpp0087651

70.3

640

7.42

FBpp0291667

59.6

537

6.61

FBpp0291668

59.6

537

8.07

FBpp0291669

64.7

584

7.11

FBpp0297644

63.3

570

8.51

FBpp0310445

63.8

577

8.51

A0A0B4LEH9

NP_001286228

AHN56026

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

554, 522 (aa)

(Mohr and Boswell, 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(var)2-10 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Su(var)2-10_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.19

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 5

organism | ubiquitous

(Mohr and Boswell, 1999)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 15

ventral nerve cord | faint

(Magalhaes et al., 2007)

adult stage oogenesis stage S10 -- S14

egg chamber

(Mohr and Boswell, 1999)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Mohr and Boswell, 1999)

embryonic stage & adult stage

(Mohr and Boswell, 1999)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in chromosome, telomeric region

inferred from direct assay

(Hari et al., 2001)

located_in cytoplasm

inferred from direct assay

(Hari et al., 2001)

located_in nuclear lamina

inferred from direct assay

(Hari et al., 2001)

located_in nucleoplasm

inferred from direct assay

(Hari et al., 2001)

located_in nucleus

inferred from direct assay

(Hari et al., 2001)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Su(var)2-10 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Su(var)2-10

View exonic expression by tissue for Dmel\Su(var)2-10

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003612

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35927/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003612

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003612

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003612

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8068

Flygut - An atlas of the Drosophila adult midgut

FBgn0003612

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Su(var)2-10

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 18 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 29 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Su(var)2-10

Transgenic constructs containing regulatory region of Su(var)2-10

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(2R)Np3

(Betz et al., 2001, Mohr and Boswell, 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)Np4

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)Np5

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)w45-30n

(Betz et al., 2001, Mohr and Boswell, 1999, BDGP Project Members, 1994-1999)

Gene not disrupted in

Df(2R)w73-1

(BDGP Project Members, 1994-1999)

In(2R)G63^Lw45-73n^R

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^en.PU

Su(var)2-10^JF03384

lethal, with Scer\GAL4^insc-Mz1407

Su(var)2-10^GD5048

lethal, with Scer\GAL4^Mef2.PR

Su(var)2-10^GD5048

lethal | recessive

lethal - all die before end of larval stage

Su(var)2-10^zimp-2

lethal - all die before end of larval stage, with Scer\GAL4^Act5C.PI

lethal - all die before end of larval stage (with Su(var)2-10¹)

Su(var)2-10²

lethal - all die before end of larval stage (with Su(var)2-10²)

lethal - all die before end of larval stage (with Su(var)2-10^Pex74a)

Su(var)2-10²

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Su(var)2-10^GD5048

lethal - all die during embryonic stage | recessive

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Su(var)2-10^GD5048

viable, with Scer\GAL4^tin.CΔ4

Su(var)2-10^GD5048

Sterility

Allele

fertile

Su(var)2-10^EY01453

Other Phenotypes

Allele

abnormal DNA repair (with Su(var)2-10¹)

Su(var)2-10²

abnormal DNA repair (with Su(var)2-10²)

Su(var)2-10¹

abnormal immune response | conditional, with Scer\GAL4^hs.PB

Su(var)2-10^GD5048

abnormal immune response | conditional, with Scer\GAL4^NP0001

abnormal meiotic cell cycle | dominant

abnormal mitotic cell cycle (with Su(var)2-10¹)

Su(var)2-10²

abnormal mitotic cell cycle (with Su(var)2-10²)

Su(var)2-10¹

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

Su(var)2-10^GD5048

abnormal size | adult stage, with Scer\GAL4^C-765

Su(var)2-10^JF01408

abnormal size | adult stage, with Scer\GAL4^ey.PH

melanotic mass phenotype (with Su(var)2-10¹)

Su(var)2-10²

melanotic mass phenotype (with Su(var)2-10²)

Su(var)2-10¹

melanotic mass phenotype | larval stage, with Scer\GAL4^Act5C.PI

some die during embryonic stage | recessive

some die during larval stage

Su(var)2-10^zimp-2

some die during larval stage (with Su(var)2-10¹)

Su(var)2-10²

some die during larval stage (with Su(var)2-10²)

some die during larval stage (with Su(var)2-10^Pex74a)

Su(var)2-10²

some die during pupal stage, with Scer\GAL4^pnr-MD237

Su(var)2-10^GD5048

suppressor of variegation, with In(1)w^m4h

Su(var)2-10¹

suppressor of variegation | dominant, with In(1)w^m4

Su(var)2-10²

suppressor of variegation | dominant, with In(1)w^m4h

Su(var)2-10^unspecified

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

Su(var)2-10²

visible, with Scer\GAL4^ey.PH

Su(var)2-10^537.UAS

visible | adult stage, with Scer\GAL4^Bx-MS1096

Su(var)2-10^JF03384

visible | adult stage, with Scer\GAL4^C-765

Su(var)2-10^JF01408

visible | adult stage, with Scer\GAL4^en.PU

visible | adult stage, with Scer\GAL4^ey.PH

visible | adult stage, with Scer\GAL4^nub.PK

wild-type, with Scer\GAL4^GMR.PF

Su(var)2-10^537.UAS

Phenotype manifest in

Allele

adult gut, with Scer\GAL4^NP0001

Su(var)2-10^537.UAS

border follicle cell

Su(var)2-10^unspecified

eye, with Scer\GAL4^ey.PH

eye | somatic clone

Su(var)2-10⁰³⁶⁹⁷

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

Su(var)2-10^GD5048

interphase & nuclear chromosome (with Su(var)2-10¹)

Su(var)2-10²

interphase & nuclear chromosome (with Su(var)2-10²)

Su(var)2-10¹

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

Su(var)2-10^GD5048

lens | somatic clone

Su(var)2-10⁰³⁶⁹⁷

ommatidium | somatic clone

Su(var)2-10⁰³⁶⁹⁷

photoreceptor neuron | somatic clone

Su(var)2-10⁰³⁶⁹⁷

polytene chromosome (with Su(var)2-10¹)

Su(var)2-10²

polytene chromosome (with Su(var)2-10²)

polytene chromosome (with Su(var)2-10^Pex74a)

Su(var)2-10²

posterior crossvein, with Scer\GAL4^en.PU

Su(var)2-10^JF03384

wing, with Scer\GAL4^Bx-MS1096

Su(var)2-10^JF03384

wing, with Scer\GAL4^C-765

Su(var)2-10^JF01408

wing blade, with Scer\GAL4^en.PU

wing blade, with Scer\GAL4^nub.PK

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (6)

Hsap\PIAS1

13 of 14

Yes

Hsap\PIAS2

12 of 14

Yes

Hsap\PIAS3

12 of 14

Yes

Hsap\PIAS4

10 of 14

Yes

Hsap\ZMIZ1

2 of 14

Hsap\ZMIZ2

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Pias1

13 of 14

Yes

Rnor\Pias2

12 of 14

Yes

Rnor\Pias3

12 of 14

Yes

Rnor\Pias4

10 of 14

Yes

Rnor\Zmiz1

2 of 14

Rnor\Zmiz2

1 of 14

Mus musculus (laboratory mouse) (6)

Mmus\Pias1

13 of 14

Yes

Mmus\Pias2

12 of 14

Yes

Mmus\Pias3

11 of 14

Yes

Mmus\Pias4

10 of 14

Yes

Mmus\Zmiz1

2 of 14

Mmus\Zmiz2

2 of 14

Xenopus tropicalis (Western clawed frog) (8)

Xtro\pias1

10 of 13

Yes

Xtro\pias4

9 of 13

Yes

Xtro\pias2

7 of 13

Yes

Xtro\pias3

7 of 13

Yes

Xtro\XB5894678

6 of 13

Yes

Xtro\grm8l

1 of 13

Xtro\slc6a16

1 of 13

Xtro\zmiz2

1 of 13

Danio rerio (Zebrafish) (7)

Drer\pias1b

12 of 14

Yes

Drer\pias2

12 of 14

Yes

Drer\pias1a

11 of 14

Yes

Drer\pias4a

8 of 14

Yes

Drer\pias4b

7 of 14

Yes

Drer\zmiz1a

1 of 14

Drer\zmiz1b

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\gei-17

8 of 14

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP005031

11 of 12

Yes

Agam\AgaP_AGAP007279

2 of 12

Arabidopsis thaliana (thale-cress) (3)

Atha\AT1G08910

7 of 13

Yes

Atha\AT5G41580

6 of 13

Yes

Atha\SIZ1

4 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\NFI1

11 of 13

Yes

Scer\SIZ1

11 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\pli1

9 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Su(var)2-10. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

tna

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

hematologic cancer, compromised sumoylation

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Su(var)2-10¹

model of hematologic cancer

CEA with Su(var)2-10²

(Kalamarz et al., 2012)

Su(var)2-10²

model of hematologic cancer

CEA with Su(var)2-10¹

(Kalamarz et al., 2012)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 6 )

Allele

Disease

Interaction

References

Su(var)2-10^HMS00750

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Su(var)2-10^JF01408

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Chang et al., 2024)

Su(var)2-10^EY01453

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Su(var)2-10^zimp-2

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(O'Rourke et al., 2013)

Su(var)2-10^GD5048

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Su(var)2-10^JF03384

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Chang et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PIAS1; protein inhibitor of activated STAT 1

13 of 14

603566

PIAS2; protein inhibitor of activated STAT 2

12 of 14

603567

PIAS3; protein inhibitor of activated STAT 3

12 of 14

605987

PIAS4; protein inhibitor of activated STAT 4

10 of 14

605989

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Su(var)2-10

enzymatic study, anti tag western blot

(Bence et al., 2024)

Su(var)2-10 - CG9426

two hybrid

(Hu et al., 2017.6.13)

Su(var)2-10 - Ets21C

two hybrid array

(Shokri et al., 2019)

Su(var)2-10 - His2Av

anti tag coimmunoprecipitation, anti tag western blot

(Tang et al., 2021)

Su(var)2-10 - Hr78

two hybrid array

(Shokri et al., 2019)

Su(var)2-10 - MEP-1

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot, luminescence based mammalian interactome mapping

(Mugat et al., 2020)

Su(var)2-10 - Mi-2

anti tag coimmunoprecipitation, western blot

(Mugat et al., 2020)

Su(var)2-10 - Panx

anti tag coimmunoprecipitation, anti tag western blot

(Ninova et al., 2020)

Su(var)2-10 - Su(var)205

anti tag coimmunoprecipitation, peptide massfingerprinting

(Alekseyenko et al., 2014)

Su(var)2-10 - Sumo

pull down, western blot, two hybrid, bimolecular fluorescence complementation, fluorescence microscopy, anti tag western blot

(Bence et al., 2024, Ninova et al., 2020)

Su(var)2-10 - Uba2

two hybrid

(Ninova et al., 2020)

Su(var)2-10 - arx

anti tag coimmunoprecipitation, anti tag western blot

(Ninova et al., 2020)

Su(var)2-10 - bon

anti tag coimmunoprecipitation, anti tag western blot

(Godneeva et al., 2023)

Su(var)2-10 - egg

luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation, anti tag western blot, western blot

(Mugat et al., 2020, Ninova et al., 2020)

Su(var)2-10 - gcm

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Jacques et al., 2009)

Su(var)2-10 - gro

two hybrid array

(Shokri et al., 2019)

Su(var)2-10 - lwr

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Ninova et al., 2020, Hu et al., 2017.6.13)

Su(var)2-10 - p53

two hybrid, pull down, autoradiography

(Pardi et al., 2011)

Su(var)2-10 - piwi

pull down, anti tag western blot, anti tag coimmunoprecipitation, bimolecular fluorescence complementation, fluorescence microscopy, western blot

(Bence et al., 2024, Mugat et al., 2020, Ninova et al., 2020)

Su(var)2-10 - stumps

two hybrid

(Battersby et al., 2003)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Su(var)2-10

suppressible

hop

(Betz et al., 2001)

Su(var)2-10

suppressible

Stat92E

(Betz et al., 2001)

Su(var)2-10

enhanceable

Stat92E

(Betz et al., 2001)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dome

suppressible

Su(var)2-10

(Ghiglione et al., 2002)

hop

suppressible

Su(var)2-10

(Betz et al., 2001)

hop

enhanceable

Su(var)2-10

(Betz et al., 2001)

smo

enhanceable

Su(var)2-10

(Zhang et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61765

DroID - A comprehensive database of gene and protein interactions.

FBgn0003612

MIST (genetic) - An integrated Molecular Interaction Database

35927

MIST (protein-protein) - An integrated Molecular Interaction Database

35927

Pathways

Signaling Pathways (FlyBase)

NEGATIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY
POSITIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY
NEGATIVE REGULATORS OF IMD SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Vitamin D (calciferol) metabolism

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7KNF5

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-60

Cytogenetic map

45A8-45A9

Sequence location

2R:9,116,122..9,122,000 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

45A8-45A9

Limits computationally determined from genome sequence between P{lacW}l(2)45Ai^k00116&P{PZ}Su(var)2-10⁰³⁶⁹⁷ and P{lacW}CG8788^k04512&P{lacW}l(2)k13412^k13412

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

45A4-45A8

(Mohr, 1998.12.16, BDGP Project Members, 1994-1999)

45A4-45A8

(determined by in situ hybridisation)

(Spradling et al., 1999)

Experimentally Determined Recombination Data

Location

2-60

(FlyBase, 2016)

2-58.2

(Comeron et al., 2012)

2-57.6 +/- 1.5

(Wustmann et al., 1989)

2-57.6

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (27)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

5526

Su(var)2-10^zimp-2/CyO

6235

In(1)w^m4h; Su(var)2-10²/CyO

29448

y¹ v¹; P{TRiP.JF03384}attP2

58067

y¹ v¹; P{TRiP.HMJ21959}attP40

64795

w¹¹¹⁸; PBac{Su(var)2-10-GFP.FPTB}VK00033

603964

w¹¹¹⁸; P{SX4.lexA::HG}Su(var)2-10^Et59/CyO

108279

8068R-1

8068R-2

HMJ21959

y¹ v¹; P{TRiP.HMJ21959}attP40/CyO

VDRC

v100813

P{KK108790}VIE-260B

v30709

w¹¹¹⁸; P{GD5048}v30709/TM3

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (146)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003612

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003612

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Andreev et al., 2022)

polyclonal

(Hari et al., 2001)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

DNA-protein interactions: genome-wide binding profile assayed for Su(var)2-10 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

(Filion et al., 2010)

Su(var)2-10 negatively regulates Stat92E.

(Betz et al., 2001)

Su(var)2-10 may control multiple aspects of chromosome structure and function by establishing/maintaining chromosome organisation in interphase nuclei.

(Hari et al., 2001)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (26)

Reported As

Symbol Synonym

CG8068

(National Institute of Genetics Fly Stocks, 2022-, Schwartz et al., 2016, Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Talamillo et al., 2008, Battersby et al., 2003)

CLOT2057

(Mohr and Boswell, 1999)

DPIAS

(Bach et al., 2003)

DmPias

(Pardi et al., 2011)

Dpias

(Ghiglione et al., 2002)

PIAS

(Rosendo Machado et al., 2021, Zhang et al., 2017, Schwartz et al., 2016, Chen et al., 2014, Kondo and Perrimon, 2011, Gutierrez-Aviño et al., 2009, Stielow et al., 2008, Shi et al., 2006, Evans et al., 2003)

SU(VAR)2-10

(Filion et al., 2010, Hari et al., 2001)

Su(Var)2-10

(Benoit et al., 2022, Transgenic RNAi Project members, 2017-, Heun et al., 2001)

Su(var)-10

(Cronin et al., 2009)

Su(var)2-10

(Liu et al., 2025, Bence et al., 2024, Petrosky et al., 2024, Godneeva et al., 2023, Zhao et al., 2023, Andreev et al., 2022, Cao et al., 2022, Ding et al., 2022, Goupil et al., 2022, Ohhara et al., 2022, Okuda et al., 2022, López-Varea et al., 2021, Onishi et al., 2021, Parkhitko et al., 2021, Tang et al., 2021, Cacchione et al., 2020, Kochanova et al., 2020, Luo et al., 2020, Meyer-Nava et al., 2020, Mugat et al., 2020, Ninova et al., 2020, Shokri et al., 2019, Huang et al., 2018, Amaral et al., 2017, Hu et al., 2017.6.13, Ota et al., 2017, Gene Disruption Project members, 2016-, Lv et al., 2016, Ma et al., 2016, Dietz et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Sanhueza et al., 2015, Alekseyenko et al., 2014, Gonzalez et al., 2014, Rogers et al., 2014, Yan et al., 2014, Elgin and Reuter, 2013, Muerdter et al., 2013, O'Rourke et al., 2013, Vasanthi et al., 2013, Antao et al., 2012, Ito et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Smith et al., 2012, Neumüller et al., 2011, Pardi et al., 2011, Sultana et al., 2011, Skora and Spradling, 2010, Ayroles et al., 2009, Stone and Ayroles, 2009, Doheny et al., 2008, Somma et al., 2008, Stielow et al., 2008, Buszczak et al., 2007, Magalhaes et al., 2007, Xing et al., 2007, Le et al., 2004, Joanis and Lloyd, 2002)

Su-var(2)10

(Wustmann et al., 1989)

Suvar(2)10

(Reuter and Spierer, 1992)

Sv210

(Ninova et al., 2023, Gamez et al., 2020, Ninova et al., 2020)

ZIMP

(Arbouzova and Zeidler, 2006)

ZimpA

(Gutierrez et al., 2003)

ZimpB

(Gutierrez et al., 2003, Aravind and Koonin, 2000)

dpias

(Jacques et al., 2009, Takanaka and Courey, 2005, Hou et al., 2002, Betz et al., 2001, Betz et al., 2001, Luo and Dearolf, 2001)

i184

(Battersby et al., 2003)

l(2)03697

(Dockendorff et al., 2000, Spradling et al., 1999)

pias

(Cronin et al., 2009)

zimp

(Mohr and Boswell, 2002, Zeidler et al., 2000, Mohr and Boswell, 1999, BDGP Project Members, 1994-1999)

Name Synonyms

Suppressor of variegation 2-10

(Talamillo et al., 2008, Xing et al., 2007)

protein inhibitor of activated STAT

(Gutierrez-Aviño et al., 2009)

suppressor of variegation 2-10

(Stone and Ayroles, 2009)

zinc finger-containing Miz1 PIAS3-like

(Mohr and Boswell, 1999)

Secondary FlyBase IDs

FBgn0010550

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

transgene_used

FBGSE22069

genome binding

Protein profiling reveals five principal chromatin types in Drosophila cells.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 117 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35927

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A1Z7P5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A1Z7P5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003612

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35927/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003612

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003612

FlyMine - An integrated database for Drosophila genomics

FBgn0003612

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8068

MARRVEL_MODEL - MARRVEL (model organism gene)

35927

Linkouts

BioGRID - A database of protein and genetic interactions.

61765

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003612

DroID - A comprehensive database of gene and protein interactions.

FBgn0003612

DRSC - Results frm RNAi screens

FBgn0003612

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Su(var)2-10_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003612

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003612

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8068

Flygut - An atlas of the Drosophila adult midgut

FBgn0003612

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0003612

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009647

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

MIST (genetic) - An integrated Molecular Interaction Database

35927

MIST (protein-protein) - An integrated Molecular Interaction Database

35927

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Vitamin D (calciferol) metabolism

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7KNF5

References (183)

The following external sites may use different assemblies or annotations than FlyBase.

0.19

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