Human Disease Model Report: hematologic cancer, compromised sumoylation

General Information

Name

hematologic cancer, compromised sumoylation

FlyBase ID

FBhh0001232

Disease Ontology Term

hematologic cancer

Parent Disease

OMIM

Overview

In Drosophila, sumoylation plays a critical role in maintenance of larval hematopoietic stem cells in an undifferentiated state. This system has been used to investigate the impact of compromised sumoylation in the development of hematologic cancers. Sumoylation also plays a role in regulating the systemic inflammation response in Drosophila, making this system useful for investigating links between cancer and inflammation.

Mutations that reduce sumoylation result in a failure of larval hematopoietic progenitors to acquire or maintain quiescence; progenitors become hyperplastic, misdifferentiate, and develop into microtumors that eventually detach from the dorsal vessel. Mutations of the Drosophila gene lwr, also known as Ubc9, have been used most extensively; lwr is orthologous to human UBE2I, a SUMO-conjugating enzyme.

Other genes used in these studies include Aos1 (orthologous to human SAE1, a SUMO-activating enzyme), Uba2 (orthologous to human UBA2, a SUMO-activating enzyme), and Su(var)2-10 (orthologous to human PIAS genes, SUMO ligases).

[updated Jul. 2020 by FlyBase; FBrf0222196]

Disease Summary Information

Disease Summary: hematologic cancer, compromised sumoylation

OMIM report

Human gene(s) implicated

Symptoms and phenotype

In Drosophila third instar larval lymph glands, a group of hematopoietic stem/progenitor cells acquires quiescence; a multicellular niche supports their undifferentiated state. Mutations that reduce sumoylation result in a failure of progenitors to acquire or maintain quiescence; progenitors become hyperplastic, misdifferentiate, and develop into microtumors that eventually detach from the dorsal vessel (FBrf0220167).

(FlyBase Curators, 2013-)

SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune responses, carcinogenesis, cell cycle progression and apoptosis. SUMO molecules are highly conserved in evolution, widely found in protozoa, metazoan, plants and fungi (Han et al, 2018; pubmed:29484374).

(FlyBase Curators, 2013-)

Genetics

Cellular phenotype and pathology

Molecular information

SUMO protein is a type of protein which is similar to ubiquitin in molecular structure. However, the amino sequence and surface charge distribution of SUMO differ from those of ubiquitin, and they have different functions (Han et al, 2018; pubmed:29484374).

(FlyBase Curators, 2013-)

External links

Disease synonyms

hematopoietic tumorigenesis, sumoylation deficient

Related Diseases

Related human health report(s)

hematologic cancer (fly models overview)

Ortholog Information

Human gene(s) in FlyBase

Other mammalian ortholog(s) used

D. melanogaster Gene Information (4)

Dmel\Su(var)2-10

Gene Snapshot

Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination. [Date last reviewed: 2019-09-26]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate- to high-scoring ortholog of human PIAS1, PIAS2, PIAS3, and PIAS4 (1 Drosophila to 4 human).

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\lwr

Gene Snapshot

lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

High-scoring ortholog of human UBE2I (1 Drosophila to 1 human).

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Aos1

Gene Snapshot

Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. [Date last reviewed: 2019-03-07]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

High-scoring ortholog of human SAE1 (1 Drosophila to 1 human).

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Uba2

Gene Snapshot

Ubiquitin-like activating enzyme 2 (Uba2) encodes one of two subunits (along with the product of Aos1) of the heterodimeric SUMO activating enzyme. It contains the catalytic cysteine residue that first becomes adenylated using ATP and that then forms a thioester linkage to the C-terminal end of SUMO. [Date last reviewed: 2019-09-26]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

High-scoring ortholog of human UBA2 (1 Drosophila to 1 human).

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (113 groups)

Su(var)2-10

protein-protein

Interacting group

Assay

References

Su(var)2-10

enzymatic study, anti tag western blot

(Bence et al., 2024)

Su(var)2-10 - arx

anti tag coimmunoprecipitation, anti tag western blot

(Ninova et al., 2020)

Su(var)2-10 - bon

anti tag coimmunoprecipitation, anti tag western blot

(Godneeva et al., 2023)

Su(var)2-10 - CG9426

two hybrid

(Hu et al., 2017.6.13)

Su(var)2-10 - egg

anti tag coimmunoprecipitation, anti tag western blot, western blot, luminescence based mammalian interactome mapping

(Mugat et al., 2020, Ninova et al., 2020)

Su(var)2-10 - Ets21C

two hybrid array

(Shokri et al., 2019)

Su(var)2-10 - gcm

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Jacques et al., 2009)

Su(var)2-10 - gro

two hybrid array

(Shokri et al., 2019)

Su(var)2-10 - His2Av

anti tag coimmunoprecipitation, anti tag western blot

(Tang et al., 2021)

Su(var)2-10 - Hr78

two hybrid array

(Shokri et al., 2019)

Su(var)2-10 - lwr

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Ninova et al., 2020, Hu et al., 2017.6.13)

Su(var)2-10 - MEP-1

luminescence based mammalian interactome mapping, anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Mugat et al., 2020)

Su(var)2-10 - Mi-2

anti tag coimmunoprecipitation, western blot

(Mugat et al., 2020)

Su(var)2-10 - p53

two hybrid, pull down, autoradiography

(Pardi et al., 2011)

Su(var)2-10 - Panx

anti tag coimmunoprecipitation, anti tag western blot

(Ninova et al., 2020)

Su(var)2-10 - piwi

pull down, anti tag western blot, bimolecular fluorescence complementation, fluorescence microscopy, anti tag coimmunoprecipitation, western blot

(Bence et al., 2024, Mugat et al., 2020, Ninova et al., 2020)

Su(var)2-10 - stumps

two hybrid

(Battersby et al., 2003)

Su(var)2-10 - Su(var)205

anti tag coimmunoprecipitation, peptide massfingerprinting

(Alekseyenko et al., 2014)

Su(var)2-10 - Sumo

pull down, western blot, bimolecular fluorescence complementation, fluorescence microscopy, two hybrid, anti tag western blot

(Bence et al., 2024, Ninova et al., 2020)

Su(var)2-10 - Uba2

two hybrid

(Ninova et al., 2020)

lwr

protein-protein

Interacting group

Assay

References

lwr

two hybrid

(Hu et al., 2017.6.13)

lwr - Adk3

two hybrid

(Hu et al., 2017.6.13)

lwr - AIMP1

enzymatic study, anti tag western blot

(Nayak et al., 2021)

lwr - Aos1

enzymatic study, autoradiography

(Long and Griffith, 2000)

lwr - ArgRS

enzymatic study, anti tag western blot

(Nayak et al., 2021)

lwr - AspRS

enzymatic study, anti tag western blot

(Nayak et al., 2021)

lwr - BEAF-32

two hybrid

(Hu et al., 2017.6.13)

lwr - cact

pull down, autoradiography

(Bhaskar et al., 2000)

lwr - CaMKII

two hybrid

(Long and Griffith, 2000)

lwr - Cf2

two hybrid

(Hu et al., 2017.6.13)

lwr - CG1888

two hybrid

(Hu et al., 2017.6.13)

lwr - CG3788

two hybrid

(Hu et al., 2017.6.13)

lwr - CG4318

two hybrid

(Hu et al., 2017.6.13)

lwr - CG4496

two hybrid

(Hu et al., 2017.6.13)

lwr - CG7737

two hybrid

(Hu et al., 2017.6.13)

lwr - CG7745

two hybrid

(Hu et al., 2017.6.13)

lwr - CG8281

two hybrid

(Hu et al., 2017.6.13)

lwr - CG8765

two hybrid

(Hu et al., 2017.6.13)

lwr - CG13895

two hybrid

(Hu et al., 2017.6.13)

lwr - CG14050

two hybrid

(Hu et al., 2017.6.13)

lwr - CG14074

two hybrid

(Hu et al., 2017.6.13)

lwr - CG14454

two hybrid

(Hu et al., 2017.6.13)

lwr - CG15514

two hybrid

(Hu et al., 2017.6.13)

lwr - CG15784

two hybrid

(Hu et al., 2017.6.13)

lwr - CG16863

two hybrid

(Hu et al., 2017.6.13)

lwr - CG17154

two hybrid

(Hu et al., 2017.6.13)

lwr - CG32486

two hybrid

(Hu et al., 2017.6.13)

lwr - CG32633

two hybrid

(Hu et al., 2017.6.13)

lwr - CG34149

two hybrid

(Hu et al., 2017.6.13)

lwr - CG44250

two hybrid

(Hu et al., 2017.6.13)

lwr - CG44251

two hybrid

(Hu et al., 2017.6.13)

lwr - CG45071

two hybrid

(Hu et al., 2017.6.13)

lwr - ci

pull down, western blot

(Lv et al., 2016)

lwr - coil

two hybrid

(Hu et al., 2017.6.13)

lwr - Coop

two hybrid

(Hu et al., 2017.6.13)

lwr - D

two hybrid

(Hu et al., 2017.6.13)

lwr - dgrn

two hybrid

(Hu et al., 2017.6.13)

lwr - DIP1

two hybrid

(Hu et al., 2017.6.13)

lwr - dl

anti tag coimmunoprecipitation, anti tag western blot, two hybrid, pull down, autoradiography

(Bhaskar et al., 2000)

lwr - ebd1

two hybrid

(Hu et al., 2017.6.13)

lwr - ERR

two hybrid

(Hu et al., 2017.6.13)

lwr - GluProRS

enzymatic study, anti tag western blot

(Nayak et al., 2021)

lwr - hbn

two hybrid

(Hu et al., 2017.6.13)

lwr - jigr1

two hybrid

(Hu et al., 2017.6.13)

lwr - jumu

experimental knowledge based

(Guruharsha et al., 2011)

lwr - LysRS

enzymatic study, anti tag western blot

(Nayak et al., 2021)

lwr - Med

two hybrid

(Miles et al., 2008)

lwr - mei-P22

two hybrid

(Hu et al., 2017.6.13)

lwr - Msp300

two hybrid

(Hu et al., 2017.6.13)

lwr - p53

two hybrid, pull down, autoradiography

(Hu et al., 2017.6.13, Pardi et al., 2011)

lwr - Panx

enzymatic study, western blot, anti tag western blot

(Andreev et al., 2022)

lwr - Pc

anti bait coimmunoprecipitation, western blot

(Liaw, 2022)

lwr - pnt

two hybrid

(Hu et al., 2017.6.13)

lwr - pnut

two hybrid

(Shih et al., 2002)

lwr - prod

two hybrid

(Hu et al., 2017.6.13)

lwr - Pu

two hybrid

(Hu et al., 2017.6.13)

lwr - Ravus

two hybrid

(Hu et al., 2017.6.13)

lwr - rdx

two hybrid

(Hu et al., 2017.6.13)

lwr - RnpS1

two hybrid

(Hu et al., 2017.6.13)

lwr - Sans

two hybrid

(Hu et al., 2017.6.13)

lwr - Scm

pull down, anti tag western blot, autoradiography

(Liaw, 2022, Smith et al., 2011)

lwr - Septin1

two hybrid

(Shih et al., 2002)

lwr - Septin2

two hybrid

(Shih et al., 2002)

lwr - sina

two hybrid

(Hu et al., 1997)

lwr - sm

two hybrid

(Hu et al., 2017.6.13)

lwr - Srr

two hybrid

(Hu et al., 2017.6.13)

lwr - stumps

two hybrid

(Battersby et al., 2003)

lwr - Su(var)2-10

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Ninova et al., 2020, Hu et al., 2017.6.13)

lwr - Sumo

experimental knowledge based, covalent binding, molecular weight estimation by staining, autoradiography, enzymatic study, pull down, western blot

(Guruharsha et al., 2011, Shih et al., 2002, Lehembre et al., 2000, Long and Griffith, 2000)

lwr - TBPH

two hybrid

(Hu et al., 2017.6.13)

lwr - TER94

two hybrid

(Hu et al., 2017.6.13)

lwr - tna

pull down, western blot, two hybrid

(Monribot-Villanueva et al., 2013)

lwr - trbd

two hybrid

(Hu et al., 2017.6.13)

lwr - TrxT

two hybrid

(Hu et al., 2017.6.13)

lwr - ttk

anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot

(Liaw, 2022)

lwr - twz

two hybrid

(Hu et al., 2017.6.13)

lwr - Uba2

anti bait coimmunoprecipitation, western blot, enzymatic study, autoradiography, experimental knowledge based

(Guruharsha et al., 2011, Shih et al., 2002, Long and Griffith, 2000)

lwr - Ubi-p5E

pull down, western blot

(Shih et al., 2002)

lwr - Ubi-p63E

pull down, western blot

(Shih et al., 2002)

lwr - z

two hybrid, pull down, anti tag western blot

(Liaw, 2022, Hu et al., 2017.6.13)

Aos1

protein-protein

Interacting group

Assay

References

Aos1 - AnxB10

experimental knowledge based

(Guruharsha et al., 2011)

Aos1 - lwr

enzymatic study, autoradiography

(Long and Griffith, 2000)

Aos1 - Sumo

enzymatic study, autoradiography

(Long and Griffith, 2000)

Aos1 - Uba2

two hybrid, pull down, molecular weight estimation by staining, experimental knowledge based

(Guruharsha et al., 2011, Shih et al., 2002, Long and Griffith, 2000)

Aos1 - UbcE2M

experimental knowledge based

(Guruharsha et al., 2011)

Uba2

protein-protein

Interacting group

Assay

References

Uba2 - Aos1

two hybrid, pull down, molecular weight estimation by staining, experimental knowledge based

(Guruharsha et al., 2011, Shih et al., 2002, Long and Griffith, 2000)

Uba2 - CaMKII

two hybrid

(Long and Griffith, 2000)

Uba2 - CG7675

experimental knowledge based

(Guruharsha et al., 2011)

Uba2 - gcm

two hybrid

(Jacques et al., 2009)

Uba2 - lwr

anti bait coimmunoprecipitation, western blot, enzymatic study, autoradiography, experimental knowledge based

(Guruharsha et al., 2011, Shih et al., 2002, Long and Griffith, 2000)

Uba2 - p53

two hybrid, pull down, autoradiography

(Pardi et al., 2011)

Uba2 - pnut

two hybrid

(Shih et al., 2002)

Uba2 - PolA1

two hybrid

(Donaghue et al., 2001)

Uba2 - Septin1

two hybrid

(Shih et al., 2002)

Uba2 - Septin2

two hybrid

(Shih et al., 2002)

Uba2 - Su(var)2-10

two hybrid

(Ninova et al., 2020)

Uba2 - Sumo

enzymatic study, covalent binding, autoradiography, pull down, western blot

(Shih et al., 2002, Long and Griffith, 2000)

Uba2 - UbcE2M

experimental knowledge based

(Guruharsha et al., 2011)

Alleles Reported to Model Human Disease (Disease Ontology) (15 alleles)

Su(var)2-10

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Su(var)2-10¹

model of hematologic cancer

CEA with Su(var)2-10²

(Kalamarz et al., 2012)

Su(var)2-10²

model of hematologic cancer

CEA with Su(var)2-10¹

(Kalamarz et al., 2012)

Modifiers Based on Experimental Evidence ( 6 )

Allele

Disease

Interaction

References

Su(var)2-10^HMS00750

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Su(var)2-10^JF01408

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Chang et al., 2024)

Su(var)2-10^EY01453

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Su(var)2-10^zimp-2

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(O'Rourke et al., 2013)

Su(var)2-10^GD5048

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Su(var)2-10^JF03384

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Chang et al., 2024)

lwr

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

lwr^4-3

model of hematologic cancer

CEA

(Kalamarz et al., 2012)

CEA with lwr⁵

(Paddibhatla et al., 2010)

lwr⁵

model of hematologic cancer

CEA

(Kalamarz et al., 2012)

CEA with lwr^4-3

(Paddibhatla et al., 2010)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

lwr⁰²⁸⁵⁸

ameliorates severe acute respiratory syndrome

modeled by HCoV-SARS\3a^{UAS.CUHK-W1.EGFP}

(Wong et al., 2005)

lwr^UAS.cAa

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-PR^PO-36.UAS

(Marmor-Kollet et al., 2020)

Aos1

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Aos1^c06048

model of hematologic cancer

CEA

(Kalamarz et al., 2012)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Uba2

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Uba2^HM05055

model of hematologic cancer

CEA

(Paddibhatla et al., 2010)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Uba2^C175S.UAS

exacerbates Kennedy's disease

modeled by Hsap\AR^{Q112.UAS.Tag:HA}

(Chan et al., 2002)

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

Contact lab of origin for a reagent not available from a public stock center.

Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

P{UAS-lwr.A}1, w^*; sna^Sco/CyO

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

y¹ v¹; P{TRiP.HM05055}attP2/TM3, Sb¹

y¹ sc^* v¹ sev²¹; P{TRiP.GL00452}attP2

y¹ v¹; P{TRiP.HMJ30299}attP40/CyO

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00067}attP2

w¹¹¹⁸; P{GD10017}v33685

y¹ v¹; P{TRiP.JF01386}attP2/TM3, Ser¹

lwr^GL00624

P{TRiP.GL00624}

y¹ sc^* v¹ sev²¹; P{TRiP.GL00624}attP40

lwr^HMS01648

P{TRiP.HMS01648}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01648}attP40

Aos1^GD8542

P{GD8542}

w¹¹¹⁸ P{GD8542}v18528

Aos1^GD16818

P{GD16818}

w¹¹¹⁸; P{GD16818}v47256

Aos1^HM05183

P{TRiP.HM05183}

y¹ v¹; P{TRiP.HM05183}attP2/TM3, Sb¹

y¹ sc^* v¹ sev²¹; P{TRiP.GL00493}attP2

Aos1^NIG.12276R

P{NIG.12276R}

P{NIG.12276R}3

Su(var)2-10^{RNAi.MN066.UAS}

P{UAS-Su(var)2-10.RNAi.MN066}

Su(var)2-10^GD5048

P{GD5048}

w¹¹¹⁸; P{GD5048}v30709/TM3

y¹ v¹; P{TRiP.JF03384}attP2

Su(var)2-10^JF01408

P{TRiP.JF01408}

y¹ v¹; P{TRiP.JF01408}attP2/TM3, Ser¹

Su(var)2-10^HMS00705

P{TRiP.HMS00705}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00705}attP2

Su(var)2-10^HMS00750

P{TRiP.HMS00750}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00750}attP2/TM3, Sb¹

Su(var)2-10^NIG.8068R

y¹ v¹; P{TRiP.HMJ21959}attP40/CyO

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

Uba2^N2

amorphic allele - molecular evidence

P-element activity

Uba2^C3

amorphic allele - molecular evidence

P-element activity

lwr⁰⁵⁴⁸⁶

loss of function allele

P-element activity

P{PZ}lwr⁰⁵⁴⁸⁶ cn¹/CyO; ry⁵⁰⁶

lwr⁰²⁸⁵⁸

P-element activity

lwr^4-3

Delta2-3 transposase

y¹ w^*; lwr^4-3 P{neoFRT}40A/CyO, y⁺

lwr^js1

loss of function allele

ethyl methanesulfonate

w^*; lwr^js1 M{3xP3-RFP.attP}ZH-51D/CyO, P{2xTb¹-RFP}CyO

lwr^js2

loss of function allele

ethyl methanesulfonate

w^*; lwr^js2 M{3xP3-RFP.attP}ZH-51D/CyO, P{2xTb¹-RFP}CyO

lwr¹³

loss of function allele

Delta2-3 transposase

y¹ w^*; P{PZ}lwr¹³ ds¹ Adc^b-1 cn¹ bw¹/CyO, y⁺

lwr¹⁴

loss of function allele

Delta2-3 transposase

lwr¹⁰

loss of function allele

Delta2-3 transposase

lwr⁵

ethyl methanesulfonate

Aos1^c06048

amorphic allele - molecular evidence

piggyBac activity

w¹¹¹⁸; PBac{PB}Aos1^c06048/TM6B, Tb¹

Aos1^N1

amorphic allele - molecular evidence

ends-out gene targeting

Aos1^N2

amorphic allele - molecular evidence

ends-out gene targeting

Su(var)2-10^EY01453

P-element activity

w¹¹¹⁸; P{EPgy2}Su(var)2-10^EY01453/CyO, P{sevRas1.V12}FK1

Su(var)2-10²

ethyl methanesulfonate

Su(var)2-10²/CyO

Su(var)2-10¹

ethyl methanesulfonate

In(1)w^m4h; Su(var)2-10¹/In(2L)t, In(2R)Cy, Duox^Cy amos^Roi-1 pr¹ cn¹

Su(var)2-10^Pex74a

amorphic allele - molecular evidence

P-element activity

Su(var)2-10^zimp-2

Su(var)2-10^zimp-2/CyO

References (5)

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