FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fus1
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General Information
Symbol
Dmel\fus1
Species
D. melanogaster
Name
FlyBase ID
FBal0085832
Feature type
allele
Associated gene
Dmel\fus
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Wakabayashi-Ito et al., 2001)
Mutagen
ethyl methanesulfonate
(Wakabayashi-Ito et al., 2001)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Wakabayashi-Ito et al., 2001)

Amino acid replacement: Q468term.

(Wakabayashi-Ito et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:15,663,585..15,663,585 [-]
Nucleotide change:

C15663585T

Reported nucleotide change:

C?T

Amino acid change:

Q134term | fus-PA; Q134term | fus-PB; Q468term | fus-PC; Q468term | fus-PD; Q468term | fus-PE; Q468term | fus-PF; Q468term | fus-PG; Q134term | fus-PH

Reported amino acid change:

Q468term

(Wakabayashi-Ito et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos produced by fus1 germ line clones are indistinguishable from wild type.

      (Wakabayashi-Ito et al., 2001)

      fus mutant homozygotes die at the end of embryogenesis with no obvious abnormality in the cuticle.

      (Ito et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      fus1/fus[+] is an enhancer of lethal | maternal effect phenotype of cactE10

      (Wakabayashi-Ito et al., 2001)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      fus1 has embryonic epidermis phenotype, non-enhanceable by Egfrt1

      (Wakabayashi-Ito et al., 2001)

      fus1 has embryonic epidermis phenotype, non-enhanceable by grk6

      (Wakabayashi-Ito et al., 2001)

      fus1 has embryonic epidermis phenotype, non-enhanceable by sqdunspecified

      (Wakabayashi-Ito et al., 2001)

      fus1 has embryonic epidermis phenotype, non-enhanceable by grk3

      (Wakabayashi-Ito et al., 2001)
      Enhancer of
      Statement
      Reference

      fus1/fus[+] is an enhancer of embryonic epidermis phenotype of cactE10

      (Wakabayashi-Ito et al., 2001)

      fus1/fus[+] is an enhancer of mesoderm phenotype of cactE10

      (Wakabayashi-Ito et al., 2001)

      fus1 is an enhancer of embryonic epidermis phenotype of cactE10

      (Ito et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      More than 80% of embryos produced by cactE10/+, fus1/+ are distinctly dorsalized, and the Egfrfus,fus2 chromosome has a similar but stronger effect. Fewer than 10% of embryos produced by cactE10/+, fus1/+ females hatch and 80-90% show the twisted body and head defects characteristic of a loss of mesoderm. Mesodermal cell types are lost.

      (Wakabayashi-Ito et al., 2001)

      cactE10/+;fus1/+ females lay 90% weakly dorsalized embryos.

      (Ito et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      fus2

      (Wakabayashi-Ito et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The lethality and the enhancing phenotype were not separated in 258 opportunities for recombination.

      (Wakabayashi-Ito et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      fus1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)