FlyBase Allele Report: Dmel\sktl[Δ20]

General Information

Symbol

Dmel\sktl^Δ20

Species

D. melanogaster

Name

FlyBase ID

FBal0094344

Feature type

allele

Associated gene

Dmel\sktl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Hassan et al., 1998)

Mutagen

Delta2-3 transposase

(Hassan et al., 1998)

Progenitor genotype

sktl^k07505

(Hassan et al., 1998)

Cytology

Description

Deletion removing the P{lacW} and 4kb of flanking genomic sequence. Deletion removes at least part of the sktl ORF.

(Hassan et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with sktl^2.3)

(Gervais et al., 2008)

lethal - all die during embryonic stage | recessive

(Hassan et al., 1998)

some die during embryonic stage | recessive

(Hassan et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

Light responses are normal in sktl^Δ20/+ flies.

(Chakrabarti et al., 2015)

Photoreceptors appear normal in sktl^Δ1-1/sktl^Δ20 animals.

(Raghu et al., 2009)

Homozygous female germline clones arrest oogenesis at stage 4.

(Gervais et al., 2008)

sktl^Δ1-1/sktl^Δ20 adults do not show photoreceptor degeneration (assayed to 72 hours after eclosion).

(Garcia-Murillas et al., 2006)

When homozygous mutant somatic clones are made in the head, almost no bristle phenotype is seen.

(Tal et al., 2002)

Lethality acts in the late embryonic stages. Mutants show no gross morphological abnormalities. No nervous system defects are visible by stage 16.

(Hassan et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

sktl^Δ20 is a non-enhancer of abnormal neurophysiology phenotype of rdgB⁹

(Chakrabarti et al., 2015)

NOT Suppressor of

Statement

Reference

sktl^Δ20 is a non-suppressor of visible phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

Other

Statement

Reference

ash1²², sktl[+]/sktl^Δ20 has visible | dominant | homeotic phenotype

(Cheng and Shearn, 2004)

ash2², sktl^Δ20 has visible | dominant | homeotic phenotype

(Cheng and Shearn, 2004)

ash2², sktl[+]/sktl^Δ20 has visible | dominant | homeotic phenotype

(Cheng and Shearn, 2004)

ash1²², sktl^Δ20 has visible | dominant | homeotic phenotype

(Cheng and Shearn, 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

sktl^Δ1-1/sktl^Δ20 is an enhancer of eye photoreceptor cell phenotype of rdgA³

(Garcia-Murillas et al., 2006)

NOT Enhancer of

Statement

Reference

sktl^Δ20 is a non-enhancer of eye photoreceptor cell phenotype of rdgB⁹

(Chakrabarti et al., 2015)

sktl^Δ20 is a non-enhancer of retina | conditional phenotype of rdgB⁹

(Chakrabarti et al., 2015)

Suppressor of

Statement

Reference

sktl^Δ1-1/sktl^Δ20 is a suppressor of rhabdomere phenotype of Pld^UAS.cRa, Scer\GAL4^GMR.PF

(Raghu et al., 2009)

NOT Suppressor of

Statement

Reference

sktl^Δ20 is a non-suppressor of eye phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

Other

Statement

Reference

ash1²², sktl[+]/sktl^Δ20 has mesothoracic leg phenotype

(Cheng and Shearn, 2004)

ash2², sktl^Δ20 has metathoracic leg | ectopic phenotype

(Cheng and Shearn, 2004)

ash1²², sktl[+]/sktl^Δ20 has metathoracic leg | ectopic phenotype

(Cheng and Shearn, 2004)

ash2², sktl[+]/sktl^Δ20 has mesothoracic leg phenotype

(Cheng and Shearn, 2004)

ash2², sktl[+]/sktl^Δ20 has metathoracic leg | ectopic phenotype

(Cheng and Shearn, 2004)

ash1²², sktl^Δ20 has mesothoracic leg phenotype

(Cheng and Shearn, 2004)

ash1²², sktl^Δ20 has metathoracic leg | ectopic phenotype

(Cheng and Shearn, 2004)

ash2², sktl^Δ20 has mesothoracic leg phenotype

(Cheng and Shearn, 2004)

Additional Comments

Genetic Interactions

Statement

Reference

sktl^Δ20 does not exacerbate the reduced electrical response to light and retinal degeneration phenotypes of rdgB⁹.

(Chakrabarti et al., 2015)

There is a dramatic increase in rhabdomere size in flies expressing Pld^Scer\UAS.cRa under the control of Scer\GAL4^GMR.PF in a sktl^Δ1-1/sktl^Δ20 background compared to flies expressing Pld^Scer\UAS.cRa under the control of Scer\GAL4^GMR.PF in a wild-type background.

(Raghu et al., 2009)

sktl^Δ1-1/sktl^Δ20 enhances the rate of photoreceptor degeneration in rdgA³ mutants.

(Garcia-Murillas et al., 2006)

ash1²² sktl^Δ20 double heterozygotes show a homeotic transformation of third leg to second leg (2.4% penetrance). ash2² sktl^Δ20 double heterozygotes show a homeotic transformation of third leg to second leg (4.3 penetrance).

(Cheng and Shearn, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sktl^k07505

(Hassan et al., 1998)

Comments

Complements insc⁸ and insc²².

(Hassan et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

39674

y¹ w^*; sktl^Δ20/CyO, P{ftz-lacB}E3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sktl^Δ20

(Sánchez-Sánchez et al., 2025, Liu et al., 2018, Bothe et al., 2014, Murray et al., 2012, Raghu et al., 2009, Gervais et al., 2008, Secombe et al., 2007)

sktl[Delta20]

(Guglielmi et al., 2015)

sktlΔ20

(Garcia-Murillas et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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