FlyBase Allele Report: Dmel\stumps[YY202]

General Information

Symbol

Dmel\stumps^YY202

Species

D. melanogaster

Name

FlyBase ID

FBal0094526

Feature type

allele

Associated gene

Dmel\stumps

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Michelson et al., 1998)

Mutagen

ethyl methanesulfonate

(Michelson et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Michelson et al., 1998)

Phenotype Manifest In

dorsal vessel wall cell

(Michelson et al., 1998)

larval pericardial cell

(Michelson et al., 1998)

larval somatic muscle cell | dorsal

(Michelson et al., 1998)

larval tracheal system

(Michelson et al., 1998)

mesoderm

(Michelson et al., 1998)

somatic trunk mesoderm

(Michelson et al., 1998)

visceral trunk mesoderm

(Michelson et al., 1998)

Detailed Description

Statement

Reference

Embryos show severe defects in the dorsolateral spreading of the invaginated mesoderm. All eve-positive mesodermal cells are missing. Most of the dorsal somatic muscles, cardial and pericardial cells fail to form. Large gaps are seen in the visceral mesoderm. Numerous primary and secondary tracheal branches are missing in homozygous embryos and the extension of those that do form is frequently stalled.

(Michelson et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

stumps^YY202 has phenotype, suppressible by Scer\GAL4^twi.PG/Ras85D^G13Q.UAS

(Michelson et al., 1998)

stumps^YY202 has mesoderm phenotype, suppressible by Scer\GAL4^twi.PG/btl::Egfr^λ.UAS

(Michelson et al., 1998)

NOT suppressed by

Statement

Reference

stumps^YY202 has mesoderm phenotype, non-suppressible by Scer\GAL4^twi.PG/htl^λ.UAS

(Michelson et al., 1998)

Enhancer of

Statement

Reference

stumps[+]/stumps^YY202 is an enhancer of larval tracheal system phenotype of btl^H82Δ3

(Michelson et al., 1998)

Suppressor of

Statement

Reference

stumps^YY202 is a suppressor of larval tracheal system phenotype of Scer\GAL4^69B, bnl^UAS.cSa

(Michelson et al., 1998)

stumps^YY202 is a suppressor of somatic muscle cell | dorsal | embryonic stage phenotype of Scer\GAL4^twi.PG, htl^λ.UAS

(Michelson et al., 1998)

stumps^YY202 is a suppressor of larval pericardial cell phenotype of Scer\GAL4^twi.PG, htl^λ.UAS

(Michelson et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos expressing htl^{Scer\UAS.T:λ\cI-DD} under the control of Scer\GAL4^twi.PG develop an increased number of eve-expressing muscle and cardiac progenitors compared to wild-type. This phenotype is dominantly suppressed by stumps^YY202. Ras85D^{G13Q.Scer\UAS} partially rescues the stumps^YY202 phenotype when expressed under the control of Scer\GAL4^twi.PG. htl^{Scer\UAS.T:λ\cI-DD} does not rescue the mesodermal phenotype of stumps^YY202 embryos when expressed under the control of Scer\GAL4^twi.PG. btl^H82Δ3 dominantly enhances the homozygous stumps^YY202 tracheal phenotype. stumps^YY202 dominantly enhances the homozygous btl^H82Δ3 tracheal phenotype. Strongly suppresses the tracheal phenotype caused by expression of bnl^Scer\UAS.cSa under the control of Scer\GAL4^69B in embryos. The lack of eve-positive mesodermal cells seen in stumps^YY202 embryos is partially rescued by btl::Egfr^{Scer\UAS.T:λ\cI-DD} expressed under the control of Scer\GAL4^twi.PG.

(Michelson et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

stumps^ems6

(Michelson et al., 1998)

stumps^ems7

(Michelson et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hbr^YY202

(Michelson et al., 1998)

stumps^YY202

(Ahmad et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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