FB2026_02 , released June 18, 2026
Allele: Hsap\APLP2::HsapAPPUAS.Tag:MYC
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General Information
Symbol
Hsap\APLP2::Hsap\APPUAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0095697
Feature type
allele
Associated gene
Hsap\APLP2::Hsap\APP
Associated Insertion(s)
Carried in Construct
P{UAS-Hsap\APLP2::Hsap\APP.T:Myc}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Fossgreen et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-Hsap\APLP2::Hsap\APP.T:Myc}
Cytology
Description

A chimeric construct in which the βA4 region and entire C-terminus of Hsap\APP695 has been replaced with the homologous region of Hsap\APLP2, tagged in the N-terminal region with Tag:MYC, is expressed under the control of UASt regulatory sequences.

(Fossgreen et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\APLP2::Hsap\APP
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\APLP2::Hsap\APPScer\UAS.T:Hsap\MYC induces cell death in the central nervous system (under the control of Scer\GAL4elav-C155), the developing eye (Scer\GAL4GMR.PF), thorax (Scer\GAL4pnr-MD237), and wing (Scer\GAL4ptc-559.1).

      (Wang et al., 2014)

      When Hsap\APLP2::Hsap\APPScer\UAS.T:Hsap\MYC is driven by Scer\GAL4sca-537.4, a phenotype in the mechanosensory organs is seen.

      (Merdes et al., 2004)

      When Hsap\APP695-Swedish.Scer\UAS is driven by Scer\GAL4Appl.G1a or Scer\GAL4179Y an accumulation of organelles is seen in larval axons (about 10 clogs per 20μm).

      (Gunawardena and Goldstein, 2001)

      Flies expressing Hsap\APLP2::Hsap\APPScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mz1087.hx have a wing blister phenotype and develop a deformation in one or both wings. Large blisters may occupy more than 50% of the wing surface and in extreme cases the wings appear like balloons. The blisters appear transparent or black, are filled with hemolymph and occur in 5-20% of flies at 25oC. The pattern of wing veins is normal. Flies expressing Hsap\APLP2::Hsap\APPScer\UAS.T:Hsap\MYC under the control of Scer\GAL469B or Scer\GAL4T80 have a wing blister phenotype. Flies expressing Hsap\APLP2::Hsap\APPScer\UAS.T:Hsap\MYC under the control of Scer\GAL430A do not have a wing blister phenotype.

      (Fossgreen et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The organelle clogging phenotype seen in mutant larvae (Driven by Scer\GAL4Appl.G1a) is suppressed by the addition of Df(3L)GN24. The organelle clogging phenotype seen in mutant larvae (Driven by Scer\GAL4Appl.G1a) is suppressed by the addition of roblK/+.

      (Gunawardena and Goldstein, 2001)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in a plasmid and transfected into SL-2 cells with a Scer\GAL4 expression plasmid. The expression and metabolism of Hsap\APLP2::Hsap\APPScer\UAS.T:Hsap\MYC protein in these cells has been studied.

      (Fossgreen et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsap\APLP2::Hsap\APPScer\UAS.T:Hsap\MYC
      Hsap\APLP2::Hsap\APPT:Hsap\MYC
      Hsap\APLP2::Hsap\APPT:Myc
      Hsap\APLP2::Hsap\APPUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)