FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\laceUAS.Tag:HA
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General Information
Symbol
Dmel\laceUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0101278
Feature type
allele
Associated gene
Dmel\lace
Associated Insertion(s)
Carried in Construct
P{UAS-lace.HA}
Also Known As
UAS-lace
Key Links
Transgenic product class
wild_type
(Adachi-Yamada et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Adachi-Yamada et al., 1999)
Mutagen
in vitro construct
(Adachi-Yamada et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-lace.HA}
Cytology
Description

UASt regulatory sequences drive expression of the entire lace coding region tagged at the N-terminal end with Tag:HA.

(Adachi-Yamada et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
lace
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Duchenne muscular dystrophy
      modeled by DysRNAi.C.UAS
      (Pantoja et al., 2013)
      modeled by DysRNAi.NH2.UAS
      (Pantoja et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of laceScer\UAS.T:Ivir\HA1 suppresses the defects in indirect flight muscle myofibril integrity seen when DysdsRNA.C.Scer\UAS is expressed under the control of Scer\GAL4tub.PU. The gross defects in indirect flight muscle morphology and reduction in overall activity levels are also suppressed.

      Expression of laceScer\UAS.T:Ivir\HA1 suppresses the reduction in activity levels seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

      (Pantoja et al., 2013)

      Expression of laceScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hh.PU does not suppress the overgrowth phenotype seen in ACC1 mutant clones in the posterior compartment of the wing disc.

      (Sasamura et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      laceUAS.Tag:HA/Scer\GAL4Tub.PU rescues lacek05305

      (West et al., 2018)

      laceUAS.Tag:HA/Scer\GAL4repo.PU rescues lacek05305

      (West et al., 2018)

      Scer\GAL4hh.PU/laceUAS.Tag:HA rescues lace2

      (Sasamura et al., 2013)

      laceUAS.Tag:HA/Scer\GAL469B rescues lace2/lacek05305

      (Adachi-Yamada et al., 1999)

      Scer\GAL4Act5C.PI/laceUAS.Tag:HA rescues lace2/lace11

      (Adachi-Yamada et al., 1999)
      Partially rescues

      laceUAS.Tag:HA/Scer\GAL4Mhc.PU partially rescues lacek05305

      (West et al., 2018)
      Fails to rescue

      Scer\GAL4elav.PU/laceUAS.Tag:HA fails to rescue lacek05305

      (West et al., 2018)
      Comments

      Expression of laceScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hh.PU rescues the overgrowth phenotype seen in lace2 mutant clones in the posterior compartment of the wing disc.

      (Sasamura et al., 2013)

      Rescues the lethality of lace11/lace2 flies when expressed under the control of Scer\GAL4Act5C.PI; approximately 50% of these flies survive to the adult stage with no aberrations. Incision of the wing margin in lacek05305/lace2 flies is rescued by laceScer\UAS.T:Ivir\HA1 expressed under the control of Scer\GAL469B.

      (Adachi-Yamada et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      laceScer\UAS.T:Ivir\HA1
      laceUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (4)