FlyBase Allele Report: Dmel\SmD3[lex47]

General Information

Symbol

Dmel\SmD3^lex47

Species

D. melanogaster

Name

FlyBase ID

FBal0102832

Feature type

allele

Associated gene

Dmel\SmD3

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Salzberg et al., 1996)

Mutagen

Delta2-3 transposase

(Salzberg et al., 1996)

Progenitor genotype

P{lacW}SmD3^k11803

(Salzberg et al., 1996)

Caused by aberration

Df(2L)guf^lex47

Cytology

Description

Deficiency removing a significant portion of the SmD3 and Oda genes.

(Schenkel et al., 1999)

Imprecise excision of the P{lacW} insertion causes a deletion that removes most of the transcription unit and the entire open reading frame.

(Salzberg et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage (with SmD3^EP2176)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k09037)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k13107)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k15401)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^ΔLR51)

(Schenkel et al., 2002)

lethal - all die during embryonic stage (with SmD3^k09540)

(Schenkel et al., 2002)

lethal - all die during embryonic stage (with SmD3^k11803)

(Schenkel et al., 2002)

lethal - all die during embryonic stage | recessive

(Salzberg et al., 1996)

some die during embryonic stage (with SmD3^k09540)

(Schenkel et al., 2002)

some die during embryonic stage (with SmD3^k11803)

(Schenkel et al., 2002)

some die during embryonic stage | recessive

(Salzberg et al., 1996)

some die during larval stage (with SmD3^EP2176)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k09037)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k13107)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k15401)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^ΔLR51)

(Schenkel et al., 2002)

Phenotype Manifest In

embryonic visceral muscle cell

(Salzberg et al., 1996)

larval somatic muscle cell

(Salzberg et al., 1996)

presumptive embryonic/larval central nervous system

(Salzberg et al., 1996)

presumptive embryonic/larval peripheral nervous system

(Salzberg et al., 1996)

Detailed Description

Statement

Reference

Smaller number of PNS neurons express 22C10 in homozygous embryos and PNS axons dispay severe defects in growth cone guidance and fasciculation. Most noticeable phenotype is splitting of the intersegmental nerve into two fascicles, the ISN 'loop' phenotype. Defects in the CNS are similar to those observed in the PNS. Numerous muscles are missing, displaced or exhibit aberrant shapes. Embryos also contain many mononucleate myoblasts that fail to fuse into muscle syncytia. Defects also in the visceral and cardiac musculature.

(Salzberg et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions