FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SmD3k13107
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General Information
Symbol
Dmel\SmD3k13107
Species
D. melanogaster
Name
FlyBase ID
FBal0100398
Feature type
allele
Associated gene
Dmel\SmD3
Associated Insertion(s)
P{lacW}SmD3k13107
Carried in Construct
Also Known As
l(2)k131-07
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Schenkel et al., 2002, Schenkel et al., 1999, Roch et al., 1998, BDGP Project Members, 1994-1999, Torok et al., 1993)
Progenitor genotype
Associated Insertion(s)
P{lacW}SmD3k13107
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethality occurs during third instar larval or pupal stages. Mutants exhibit visible disc abnormalities. In tergites, clones with normal size and frequency are recovered. Clones cannot be recovered in the wing disc.

      (Roch et al., 1998)

      Brain, imaginal disc and blood cell neoplastic phenotype.

      (Mechler, 1994)

      Brain is of normal size but abnormal shape. Wing and haltere discs rarely showing hyperplastic outgrowths, folding abnormal. Lymph gland retains lobular structure.

      (Torok et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

      The level of SmD3 transcript is strongly reduced in P{lacW}SmD3k13107 homozygotes compared to wild type, whereas Oda expression remains essentially unaffected. The level of SmD3 protein is lowered compared to wild type in P{lacW}SmD3k13107/+ larvae and strongly reduced in P{lacW}SmD3k13107 homozygous larvae. The P{lacW}SmD3k13107 insertion appears to affect only SmD3 function and not Oda function (despite being within an Oda intron), since the lethality of P{lacW}SmD3k13107 homozygotes is fully rescued by the P{SmD3.+t2.3} construct which contains the complete SmD3 gene. Complements: OdaEP2104.

      (Schenkel et al., 2002)

      Two or three different shades of eye colour were observed, this phenotype is caused by the presence of a P{lacW} insert into another autosome cytological location 49B. P-element excision from cytological location 48E demonstrates the 48E insertion to be the cause of lethality.

      (Torok et al., 1993)

      Complements: fdlk17040. Fails to complement: SmD3k09029. Fails to complement: SmD3k13101.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      131/7
      (Roch et al., 1998)
      SmD3k13107
      gufk13107
      l(2)131/7
      (Mechler, 1994, Torok et al., 1993)
      l(2)k09037k13107
      l(2)k131-07
      (Anne et al., 2007, Schenkel et al., 2002, Schenkel et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)