FlyBase Allele Report: Dmel\SmD3[k09540]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\SmD3^k09540

General Information

Symbol

Dmel\SmD3^k09540

Species

D. melanogaster

Name

FlyBase ID

FBal0100400

Feature type

allele

Associated gene

Associated Insertion(s)

P{lacW}SmD3^k09540

Carried in Construct

Also Known As

95/40

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Salzberg et al., 1996)

Mutagen

P-element activity

(Kania et al., 1995)

Progenitor genotype

Associated Insertion(s)

P{lacW}SmD3^k09540

Cytology

Description

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage (with SmD3^EP2176)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k09037)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k13107)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k15401)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^ΔLR51)

(Schenkel et al., 2002)

lethal - all die during embryonic stage (with SmD3^k11803)

(Schenkel et al., 2002)

lethal - all die during embryonic stage (with SmD3^lex47)

(Schenkel et al., 2002)

lethal - all die during embryonic stage | recessive

(Schenkel et al., 2002, Salzberg et al., 1996, Kania et al., 1995)

some die during embryonic stage (with SmD3^k11803)

(Schenkel et al., 2002)

some die during embryonic stage (with SmD3^lex47)

(Schenkel et al., 2002)

some die during embryonic stage | recessive

(Schenkel et al., 2002, Salzberg et al., 1996, Kania et al., 1995)

some die during larval stage (with SmD3^EP2176)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k09037)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k13107)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k15401)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^ΔLR51)

(Schenkel et al., 2002)

Phenotype Manifest In

chordotonal organ

(Schenkel et al., 2002)

embryonic visceral muscle cell

(Salzberg et al., 1996)

larval somatic muscle cell

(Salzberg et al., 1996)

larval ventral nerve cord

(Schenkel et al., 2002)

presumptive embryonic/larval central nervous system

(Salzberg et al., 1996)

presumptive embryonic/larval peripheral nervous system

(Salzberg et al., 1996, Kania et al., 1995)

Detailed Description

Statement

Reference

Mutant embryos show defects in the lateral chordotonal organs and the ventral nerve cord.

(Schenkel et al., 2002)

Homozygous embryos exhibit loss of neurons.

(Kania et al., 1995)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

(Schenkel et al., 2002)

(Schenkel et al., 2002)

(Schenkel et al., 2002)

(Schenkel et al., 2002)

(Schenkel et al., 2002)

(Schenkel et al., 2002)

(Schenkel et al., 2002)

(BDGP Project Members, 1994-1999)

Rescued by

SmD3^k09540 is rescued by SmD3^+t2.3

(Schenkel et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Comments

This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

The P{lacW}SmD3^k09540 insertion appears to affect only SmD3 function and not Oda function (despite being within an Oda intron), since the lethality of P{lacW}SmD3^k09540 homozygotes is fully rescued by the P{SmD3.+t2.3} construct which contains the complete SmD3 gene. Complements: Oda^EP2104.

(Schenkel et al., 2002)

Lethality not revertible with excision of the P{lacW} insert. P{lacW}SmD3^k09512 and P{lacW}SmD3^k09540 insertions might be members of the same cluster and not genuine alleles.

(Kania et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

95/40

(Salzberg et al., 1996, Kania et al., 1995)

SmD3^k09540

guf^P95-40

(Salzberg et al., 1996)

guf^k09540

l(2)k095-40

(Schenkel et al., 2002, Schenkel et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections