FlyBase Allele Report: Dmel\sbb[1]

General Information

Symbol

Dmel\sbb¹

Species

D. melanogaster

Name

FlyBase ID

FBal0117382

Feature type

allele

Associated gene

Dmel\sbb

Associated Insertion(s)

Carried in Construct

Also Known As

bks¹

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Senti et al., 2000)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | third instar larval stage (with sbb³²⁴)

(Suster et al., 2004)

lethal | recessive

(Senti et al., 2000)

lethal - all die before end of pupal stage (with sbb³²⁴)

(Suster et al., 2004)

Phenotype Manifest In

lamina plexus | somatic clone

(Senti et al., 2000)

lamina plexus | somatic clone (with sbb²)

(Senti et al., 2000)

photoreceptor cell & axon | somatic clone (with sbb²)

(Senti et al., 2000)

photoreceptor cell R1 & axon | somatic clone

(Senti et al., 2000)

photoreceptor cell R1 & axon | somatic clone, with sbb^{A.GMR.Tag:MYC}

(Senti et al., 2000)

photoreceptor cell R1 & axon | somatic clone (with sbb⁰⁴⁴⁴⁰)

(Senti et al., 2000)

photoreceptor cell R1 & axon | somatic clone (with sbb^k00702)

(Senti et al., 2000)

photoreceptor cell R2 & axon | somatic clone

(Senti et al., 2000)

photoreceptor cell R2 & axon | somatic clone, with sbb^{A.GMR.Tag:MYC}

(Senti et al., 2000)

photoreceptor cell R2 & axon | somatic clone (with sbb⁰⁴⁴⁴⁰)

(Senti et al., 2000)

photoreceptor cell R2 & axon | somatic clone (with sbb^k00702)

(Senti et al., 2000)

photoreceptor cell R3 & axon | somatic clone

(Senti et al., 2000)

photoreceptor cell R3 & axon | somatic clone, with sbb^{A.GMR.Tag:MYC}

(Senti et al., 2000)

photoreceptor cell R3 & axon | somatic clone (with sbb⁰⁴⁴⁴⁰)

(Senti et al., 2000)

photoreceptor cell R3 & axon | somatic clone (with sbb^k00702)

(Senti et al., 2000)

photoreceptor cell R4 & axon | somatic clone

(Senti et al., 2000)

photoreceptor cell R4 & axon | somatic clone, with sbb^{A.GMR.Tag:MYC}

(Senti et al., 2000)

photoreceptor cell R4 & axon | somatic clone (with sbb⁰⁴⁴⁴⁰)

(Senti et al., 2000)

photoreceptor cell R4 & axon | somatic clone (with sbb^k00702)

(Senti et al., 2000)

photoreceptor cell R5 & axon | somatic clone

(Senti et al., 2000)

photoreceptor cell R5 & axon | somatic clone, with sbb^{A.GMR.Tag:MYC}

(Senti et al., 2000)

photoreceptor cell R5 & axon | somatic clone (with sbb⁰⁴⁴⁴⁰)

(Senti et al., 2000)

photoreceptor cell R5 & axon | somatic clone (with sbb^k00702)

(Senti et al., 2000)

photoreceptor cell R6 & axon | somatic clone

(Senti et al., 2000)

photoreceptor cell R6 & axon | somatic clone, with sbb^{A.GMR.Tag:MYC}

(Senti et al., 2000)

photoreceptor cell R6 & axon | somatic clone (with sbb⁰⁴⁴⁴⁰)

(Senti et al., 2000)

photoreceptor cell R6 & axon | somatic clone (with sbb^k00702)

(Senti et al., 2000)

ventral denticle belt | maternal effect

(Haecker et al., 2007)

Detailed Description

Statement

Reference

Embryos derived from homozygous germline clones show segmentation defects, with loss of denticle belts.

(Haecker et al., 2007)

Third instar larvae transheterozygous for sbb¹/sbb³²⁴ display a significant increase in turning rate during crawling, as compared to controls.

(Suster et al., 2004)

Mosaics in which almost all of the eye is homozygous for sbb¹ while other tissues are heterozygous (clones generated using the "eyFLP" system) show striking defects in photoreceptor axon projections; photoreceptor axons project normally through the optic stalk to the brain, but fail to segregate into their distinct target layers. Only a vestigial lamina plexus is formed, while thick bundles of photoreceptor axons project through to the medulla. R1-R6 photoreceptor axons overshoot their targets in sbb¹/sbb⁰⁴⁴⁴⁰ or sbb¹/sbb^k00702 transheterozygous larvae. Cells in homozygous clones in the eye imaginal disc undergo normal photoreceptor differentiation.

(Senti et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sbb³³⁹

(Haecker et al., 2007)

sbb²⁷⁸

(Haecker et al., 2007)

sbb¹⁴

(Haecker et al., 2007)

sbb²

(Senti et al., 2000)

sbb⁰⁴⁴⁴⁰

(Senti et al., 2000)

sbb^k00702

(Senti et al., 2000)

Rescued by

sbb¹ is rescued by sbb^B.GMR

(Senti et al., 2000)

Partially rescued by

sbb¹ is partially rescued by sbb^{A.GMR.Tag:MYC}

(Senti et al., 2000)

Comments

The photoreceptor R1-R6 cell targeting defects of sbb¹ mosaics (in which almost all of the eye is homozygous for sbb¹ while other tissues are heterozygous) are partially rescued by sbb^{A.GMR.T:Hsap\MYC}; most R1-R6 axons correctly target the lamina, although a small number of R1-R6 axons in each hemisphere, predominantly those in the posterior regions of the eye, still project through the lamina to terminate in the medulla.

(Senti et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a mutation that autonomously disrupts the projection patterns of photoreceptor axons from the eye imaginal disc into the optic lobe of the brain.

(Senti et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

bks¹

(Haecker et al., 2007, Shen and Dahmann, 2005, Senti et al., 2000)

sbb¹

(Suster et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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