FB2026_02 , released June 18, 2026
Allele: Dmel\sbb6
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General Information
Symbol
Dmel\sbb6
Species
D. melanogaster
Name
FlyBase ID
FBal0121536
Feature type
allele
Associated gene
Dmel\sbb
Associated Insertion(s)
Carried in Construct
Also Known As
mtv6
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Funakoshi et al., 2001)
Mutagen
P-element activity
(Funakoshi et al., 2001)
Progenitor genotype
sbbk00702
(Funakoshi et al., 2001)
Cytology
Description

Imprecise excision of the P{lacW} element resulting in a 4kb deletion. The protein produced consists of only 19 amino acids.

(Funakoshi et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sbbplt/sbb6 mutants exhibit a wing vein phenotype wherein wing vein L5 fails to reach the wing margin, and males of these mutants also fail to copulate.

      (Yilmazer et al., 2016)

      Homozygous clones in the wing result in loss of wing margin.

      (Bejarano et al., 2008)

      24% of sbbEal17/sbb6 pharate adults have defective claws.

      Homozygous clones in the leg results in a severe reduction in the size, particularly the width, of claws composed of mutant tissue. Homozygous clones in the antenna result in aristae which are reduced in length and fatter than normal and some sense organs on the third antennal segment are absent or lacking setae.

      The ocellar triangle region is compressed in sbbEal17/sbb6 flies, resulting in fusion of ocelli, loss of interocellar bristles and loss and mispositioning of the ocellar bristles.

      Homozygous clones result in almost complete loss of the ocellar triangle region, with a single ocellus often being the only structure remaining.

      Homozygous clones result in defects in the wing margin; in the proximal anterior region, the large wide central bristles that normally develop in the triple row in this region are thinner than normal and in the posterior region, the bristles develop a socket and are longer than normal, indicating a partial transformation to the anterior fate.

      Homozygous embryos derived from homozygous female germline clones have a segmental phenotype consisting of the deletion of three or more abdominal segments.

      (Wehn and Campbell, 2006)

      Homozygous clones in the wing result in abnormal phenotypes. Clones anterior to the second vein result in an ectopic vein anterior to the second vein and triple row bristles are transformed to double row bristles. A slight increase in the area posterior to vein L5 is seen and the vein pattern between L3 and L4 is disrupted.

      (Funakoshi et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      sbb[+]/sbb6 is an enhancer of visible | dominant phenotype of Bx1

      (Bejarano et al., 2008)

      sbb[+]/sbb6 is an enhancer of visible | dominant phenotype of hhMrt

      (Bejarano et al., 2007)
      Other
      Statement
      Reference

      groE48/gro1, sbb[+]/sbb6 has visible phenotype

      (Bejarano et al., 2007)

      Gug[+]/GugEal15, sbb6 has visible | dominant phenotype

      (Wehn and Campbell, 2006)

      Gug35/Gug[+], sbb6 has visible | dominant phenotype

      (Wehn and Campbell, 2006)

      groE48/gro[+], sbb6 has visible | dominant phenotype

      (Wehn and Campbell, 2006)

      groEal13/gro[+], sbb6 has visible | dominant phenotype

      (Wehn and Campbell, 2006)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Loss of one copy of sbb6 strongly enhances the hhMrt heterozygous adult wing phenotype. Wings show duplication of longitudinal wing vein L3 tissue, and enlargement of the anterior compartment. The sensory organs located in the most anterior wing margin (triple row bristles) are transformed into more posteriorly located bristles (double row bristles).

      gro1/groE48 adults heterozygous for sbb6 show an enlarged anterior wing compartment. Ectopic longitudinal wing vein L2 and L3 tissue develops, and transformation of the anterior wing margin bristles into more posteriorly located sensory organs is observed.

      (Bejarano et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (6)