FlyBase Allele Report: Dmel\vtd[80Fh-36]

General Information

Symbol

Dmel\vtd^80Fh-36

Species

D. melanogaster

Name

FlyBase ID

FBal0123590

Feature type

allele

Associated gene

Dmel\vtd

Associated Insertion(s)

Carried in Construct

Also Known As

vtd³⁶

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Schulze et al., 2001, Sinclair et al., 2000)

Progenitor genotype

Cytology

Description

Amino acid replacement: V49E.

(Hallson et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:27,136,757..27,136,757 [+]

Nucleotide change:

T27136757A

Amino acid change:

V49E | vtd-PA; V49E | vtd-PB

Reported amino acid change:

V49E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Hallson et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage (with vtd⁴)

(Schulze et al., 2001)

lethal - all die before end of pupal stage | recessive

(Schulze et al., 2001)

some die during pupal stage (with vtd⁴)

(Schulze et al., 2001)

some die during pupal stage | recessive

(Schulze et al., 2001)

Phenotype Manifest In

abdominal segment | adult stage

(Schaaf et al., 2013)

Detailed Description

Statement

Reference

vtd^80Fh-36 heterozygotes exhibit a mild and weakly penetrant A5 to A4 abdominal segment transformation phenotype.

(Schaaf et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

vtd^80Fh-36/vtd[+] is an enhancer of visible phenotype of N^spl-1

(Schaaf et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

vtd^80Fh-36 has abdominal segment | adult stage phenotype, enhanceable by Nipped-B[+]/Nipped-B⁴⁰⁷

(Schaaf et al., 2013)

Enhancer of

Statement

Reference

vtd^80Fh-36/vtd[+] is an enhancer of eye phenotype of N^spl-1

(Schaaf et al., 2009)

vtd^80Fh-36/vtd[+] is an enhancer of scutellar bristle phenotype of N^spl-1

(Schaaf et al., 2009)

Suppressor of

Statement

Reference

vtd^80Fh-36 is a suppressor of sex comb | ectopic phenotype of Pc¹

(Schaaf et al., 2013)

vtd^80Fh-36 is a suppressor of sex comb | ectopic phenotype of Pc⁶

(Schaaf et al., 2013)

vtd^80Fh-36 is a suppressor of sex comb | ectopic phenotype of Psc¹

(Schaaf et al., 2013)

vtd^80Fh-36 is a suppressor of sex comb | ectopic phenotype of Sce¹

(Schaaf et al., 2013)

vtd^80Fh-36 is a suppressor of sex comb | ectopic phenotype of ph-d⁴⁰¹

(Schaaf et al., 2013)

vtd^80Fh-36 is a suppressor of abdominal segment | adult stage phenotype of ph-d⁴⁰¹

(Schaaf et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The lack of scutellar bristles seen in N^spl-1 flies is enhanced by vtd^80Fh-36/+.

(Schaaf et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

vtd⁴

(Schulze et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

vtd^80Fh-35 and vtd^80Fh-36 contain identical missense mutations and were isolated in the same screen, so it is possible that both derive from the same premeiotic mutagenic event.

(Hallson et al., 2008)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

(Sinclair et al., 2000)

Rad21³⁶

(Schaaf et al., 2013)

vtd³⁶

(Schaaf et al., 2013, Schaaf et al., 2009, Hallson et al., 2008)

vtd^80Fh-36

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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