FlyBase Allele Report: Dmel\toy[G7.39]

General Information

Symbol

Dmel\toy^G7.39

Species

D. melanogaster

Name

FlyBase ID

FBal0123656

Feature type

allele

Associated gene

Dmel\toy

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Punzo et al., 2002)

loss of function allele

(Kammermeier et al., 2001)

Mutagen

ethyl methanesulfonate

(Kammermeier et al., 2001)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die

(Jacobsson et al., 2009)

some die during pharate adult stage

(Jacobsson et al., 2009)

Phenotype Manifest In

eye disc

(Punzo et al., 2002)

ocellus

(Jacobsson et al., 2009)

Detailed Description

Statement

Reference

The proportion of flies with normal ocelli among the toy^G7.39 homozygous mutant escapers is 29% at 18[o]C.

(Jacobsson et al., 2009)

The size of the eye discs can vary from a small cluster of cells to almost wild-type in mutant larvae, and the two discs of a single larva can be very different in size.

(Punzo et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

toy^G7.39 has partially lethal - majority die | pharate adult stage phenotype, suppressible | partially by Scer\GAL4^toy1/ey^UAS.cHa

(Jacobsson et al., 2009)

toy^G7.39 has partially lethal - majority die | pharate adult stage phenotype, suppressible by Scer\GAL4^toy2/BacA\p35^UAS.cHa

(Jacobsson et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

toy^G7.39 has ocellus phenotype, suppressible by Scer\GAL4^toy1/ey^UAS.cHa

(Jacobsson et al., 2009)

NOT suppressed by

Statement

Reference

toy^G7.39 has ocellus phenotype, non-suppressible by Scer\GAL4^toy2/BacA\p35^UAS.cHa

(Jacobsson et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of ey^Scer\UAS.cHa under the control of Scer\GAL4^toy1 partially suppresses the pupal lethality found in toy^hdl mutants, increasing the percentage of escapers from 5.1 to 9.5%.

Expression of ey^Scer\UAS.cHa under the control of Scer\GAL4^toy1 or Scer\GAL4^toy2 suppresses the ocellar phenotype found in toy^G7.39 mutants in 85% of adult escapers.

(Jacobsson et al., 2009)

Xenogenetic Interactions

Statement

Reference

Expression of BacA\p35^Scer\UAS.cHa under the control of Scer\GAL4^toy2 significantly increases the survival of toy^G7.39 homozygous mutants to the adult stage. The ocellar defects in these rescued flies do not improve.

(Jacobsson et al., 2009)

Complementation and Rescue Data

Rescued by

toy^G7.39 is rescued by toy^UAS.cCa/Scer\GAL4^toy1

(Jacobsson et al., 2009)

toy^G7.39 is rescued by toy^UAS.cCa/Scer\GAL4^toy2

(Jacobsson et al., 2009)

Comments

Expression of toy^Scer\UAS.cCa under the control of Scer\GAL4^toy1 or Scer\GAL4^toy2 is able to rescue homozygous mutant toy^G7.39 flies.

Expression of toy^Scer\UAS.cCa under the control of Scer\GAL4^toy1 or Scer\GAL4^toy2 rescues the ocellar phenotype found in toy^G7.39 mutants in 90% of flies.

The presence of toy^Scer\UAS.cCa, without a Scer\GAL4 driver can rescue toy^G7.39 at high temperatures (e.g. >25[o]C).

(Jacobsson et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26797

toy^G7.39/In(4)ci^D, ci^D pan^ciD

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

toy^G7.39

(Jacobsson et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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