FlyBase Allele Report: Dmel\sov[KG00226]

General Information

Symbol

Dmel\sov^KG00226

Species

D. melanogaster

Name

FlyBase ID

FBal0128281

Feature type

allele

Associated gene

Dmel\sov

Associated Insertion(s)

P{SUPor-P}sov^KG00226

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}sov^KG00226

Cytology

Description

Insertion at position 3116 relative to the first transcription start site of sov.

(Benner et al., 2019)

Allele components

Component

Use(s)

Inserted element

P{SUPor-P}

insertional mutagenesis tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:6,759,438..6,759,438 [+]

(Benner et al., 2019, Branco et al., 2008, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Branco et al., 2008)

exacerbates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

ameliorates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

CG14438^KG00226 has different effects on different aspects of the Hsap\ATXN1^82Q.Scer\UAS olivopontocerebellar atrophy model ; the retinal phenotypes are exacerbated, but the number of nuclear inclusions is ameliorated.

(Branco et al., 2008)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile

(Benner et al., 2019)

female fertile (with Df(1)sov)

(Benner et al., 2019)

female fertile (with sov²)

(Benner et al., 2019)

female fertile (with sov^NP6070)

(Benner et al., 2019)

female sterile (with sov^EA42)

(Benner et al., 2019)

female sterile (with sov^ML150)

(Benner et al., 2019)

partially lethal (with Df(1)sov)

(Benner et al., 2019)

partially lethal (with sov^EA42)

(Benner et al., 2019)

partially lethal (with sov^ML150)

(Benner et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

No retinal phenotypes are seen in CG14438^KG00226 mutant flies.

(Branco et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

CG14438[+]/sov^KG00226 is an enhancer of visible | adult stage phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

CG14438[+]/sov^KG00226 is an enhancer of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

CG14438[+]/sov^KG00226 is an enhancer of ommatidium phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

CG14438[+]/sov^KG00226 is an enhancer of interommatidial bristle phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

CG14438[+]/sov^KG00226 is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Suppressor of

Statement

Reference

CG14438[+]/sov^KG00226 is a suppressor of retina phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

One copy of CG14438^KG00226 suppresses the retinal phenotype seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of CG14438^KG00226 enhances the external eye and retinal phenotypes seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

One copy of CG14438^KG00226 reduces the number of neurons that contain nuclear inclusions seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^ey-OK107.

One copy of CG14438^KG00226 has no effect on the number of neurons that contain nuclear inclusions seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^ey-OK107.

(Branco et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

13068

y¹ P{SUPor-P}sov^KG00226

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG14438^KG00226

(Branco et al., 2008)

CG14438^LOF

(Branco et al., 2008)

sov^KG00226

(Benner et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close