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General Information
Symbol
Dmel\Pdk15
Species
D. melanogaster
Name
FlyBase ID
FBal0135872
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dPDK15, EP837
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C142372T

Reported nucleotide change:

C?T

Amino acid change:

Q394term | Pdk1-PA; Q178term | Pdk1-PB; Q458term | Pdk1-PC; Q475term | Pdk1-PD; Q178term | Pdk1-PE; Q394term | Pdk1-PF; Q178term | Pdk1-PG; Q394term | Pdk1-PH; Q475term | Pdk1-PJ

Reported amino acid change:

Q437term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q437term.

The progenitor P{EP}Pdk1EP837 insertion is also still present.

Nucleotide substitution: C?T.

Insertion components
P{EP}EP837
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones in the wing disc are reduced in size by 78% compared to their wild-type twin spot clones.

Pk61C4/Pk61C5 surviving flies have reduced heads.

Homozygous Pk61C5 larvae and transheterozygous Pk61C5/Pk61CEP3091 larvae die during the second instar. Pk61C5/Pk61C4 flies are delayed in development for one day, smaller than normal and have an 18% reduction in body weight. This reduction in size and weight is primarily due to a decrease in cell size. Pk61C5/Pk61C4 male flies are almost completely sterile, although they show no obvious defect in sperm morphology or in mating behaviour. Photoreceptor cells within homozygous clones in the eye are about 30% smaller than heterozygous cells outside the clone. This phenotype is cell autonomous. The heads of mosaic flies with homozygous heads (generated using the "ey-FLP" system) are reduced in size.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Other
Phenotype Manifest In
NOT suppressed by
Statement
Reference

Pdk15 has wing disc | somatic clone phenotype, non-suppressible by Atg1Δ3D

Other
Additional Comments
Genetic Interactions
Statement
Reference

The reduced size of Pk61C5 clones in the wing disc is not altered if the clones are also homozygous for Atg1Δ3D.

Ptendj189/Ptenc494 ; Pk61C4/Pk61C5 animals can survive to adulthood, although the abdomen is unproportionally reduced in size and leg structures are deformed.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a suppressor of the big eye phenotype caused by coexpression of Akt1Scer\UAS.cRa and Pk61CEP837 under the control of Scer\GAL4GMR.PF.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)