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General Information
Symbol
Dmel\wgndsRNA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0138107
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Wengen-IR, UAS-Wgn-IR
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of two copies of wgn cDNA sequences in a head-to-head inverted repeat orientation.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

No evidence of NMJ degeneration is seen when wgndsRNA.Scer\UAS is expressed under the control of Scer\GAL4elav-C155 and the number of boutons is comparable to wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of wgndsRNA.Scer\UAS does not suppress the rough eye phenotype seen when bend09936 is expressed under the control of Scer\GAL4ey.PU.

Expression of wgndsRNA.Scer\UAS does not suppress the small scutellum phenotype seen when benEP1651 is expressed under the control of Scer\GAL4pnr.PU.

Expression of wgndsRNA.Scer\UAS under the control of Scer\GAL4elav-C155 partially suppresses the NMJ degeneration seen in Ank2f02001 mutant third instar larvae. The axonal blockages and microtubule disruption are not suppressed.

Expression of wgndsRNA.Scer\UAS under the control of Scer\GAL4elav-C155 partially suppresses the synaptic transmission defects seen in Ank2f02001 mutants. A near complete rescue in the number of small EPSPs is seen, however average EPSP amplitude is not completely restored to wild type levels.

The eye phenotype in Ras85DKP mutant flies is partially suppressed by ectopic expression of wgndsRNA.Scer\UAS in the eye under the control of Scer\GAL4GMR.PF.

Co-expression of wgndsRNA.Scer\UAS does not suppress the reduced scutellum phenotype caused by expression of CYLDScer\UAS.cXa under the control of Scer\GAL4pnr-MD237.

Expression of wgndsRNA.Scer\UAS (under the control of Scer\GAL4Act5C.PI) using the FLP/FRT system partially suppresses metastatic behaviour in l(2)gl4 mutants expressing Ras85DV12.Scer\UAS.

Co-expression of wgndsRNA.Scer\UAS suppresses the small eye phenotype caused by expression of egrGS9830 under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference

Co-expression of wgndsRNA.Scer\UAS does not suppress the wing defects caused by expression of HIV-1\VpuScer\UAS.cLa under the control of Scer\GAL4dpp.blk1.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Carried in plasmid P{UAS-wengen-IR} and transfected into S2 cells.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
wgndsRNA.Scer\UAS
wgndsRNA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (11)