FlyBase Allele Report: Dmel\dgo[380]

General Information

Symbol

Dmel\dgo³⁸⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0141190

Feature type

allele

Associated gene

Dmel\dgo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Feiguin et al., 2001)

Progenitor genotype

dgo^EP2619

(Feiguin et al., 2001)

Cytology

Description

Imprecise excision of P{EP}EP2619^EP2619 caused a unidirectional deletion beginning at the insertion site and terminating in dgo at ?.

(Feiguin et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Jones et al., 2014, Rawls et al., 2007, Das et al., 2004, Feiguin et al., 2001)

abnormal planar polarity | somatic clone

(Jenny et al., 2005)

male fertile

(Steinhauer et al., 2019)

viable

(Feiguin et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

dgo³⁸⁰ testes have significantly fewer normal individualization complexes (ICs) while they have a similar number of abnormal ICs when compared to controls.

(Steinhauer et al., 2019)

dgo^EGFP.N, dgo³⁸⁰ individuals exhibit normal wings with normal trichome polarity.

(Strutt et al., 2016)

The wings of homozygous dgo³⁸⁰ mutant flies exhibit strong polarity defects and display a stereotypical whorl phenotype.

Homozygous dgo³⁸⁰ mutant flies exhibit strong polarity defects in the eye, including loss of chirality and misoriented facets.

(Jones et al., 2014)

Overall length of the tracheal dorsal trunk is normal in hemizygous stage 16 embryos.

(Chung et al., 2009)

Many dgo³⁸⁰ ommatidia mis-rotate; the variance (s.d.) in degree of rotation is greater than in wild type in adult eyes.

(Fetting et al., 2009)

Homozygotes show defects in ommatidial polarity.

(Rawls et al., 2007)

The formation of holes in wings due to temperature shift of shi¹/shi¹ animals during pupal stages is moderately enhanced by dgo³⁸⁰/+.

(Classen et al., 2005)

In developing eyes which are mosaic for dgo³⁸⁰, when the R3 photoreceptor precursor is wild type, the ommatidial cluster adopts the correct polarity, but when the R3 precursor is dgo³⁸⁰, clusters often adopt random polarity, leading to symmetrical clusters or chirality flips.

(Jenny et al., 2005)

The ommatidia of dgo³⁸⁰ mutant flies have either randomized chirality, are misrotated or are symmetrical (R3/R3 or R4/R4 cell pairs replace R3/R4 pairs).

(Das et al., 2004)

dgo³⁸⁰ homozygotes have moderately severe planar polarity defects in wing hairs and ommatidia but only mild planar polarity defects in bristles. The eye defects include misrotation and inverted chirality (average 38.4+/-11.2 % of ommatidia) and symmetrical ommatidia (average 28.6+/-13.1 % of ommatidia). dgo³⁸⁰/Df(2R)27 flies appear to be phenotypically identical.

(Feiguin et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^hs.2sev, dgo[+]/dgo³⁸⁰, shg^{dCR3h.UAS.sgGFP} has abnormal cell polarity phenotype, enhanceable by Vang^stbm-6/Vang[+]

(Mirkovic and Mlodzik, 2006)

Suppressed by

Statement

Reference

dgo³⁸⁰ has abnormal planar polarity phenotype, suppressible by Scer\GAL4^hh-Gal4/Mmus\Ankrd6^UAS.cJa

(Jones et al., 2014)

dgo³⁸⁰ has abnormal planar polarity phenotype, suppressible by bdg[+]/bdg^GMREP

(Rawls et al., 2007)

dgo³⁸⁰ has abnormal planar polarity phenotype, suppressible by bdg¹⁶⁴/bdg[+]

(Rawls et al., 2007)

Enhancer of

Statement

Reference

dgo[+]/dgo³⁸⁰ is an enhancer of abnormal planar polarity phenotype of CG15283^GD13108, Scer\GAL4^en-e16E

(Weber et al., 2012)

dgo[+]/dgo³⁸⁰ is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

dgo[+]/dgo³⁸⁰ is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, Vang^stbm-6/Vang[+], shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

dgo³⁸⁰ is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, Vang^UAS.cWa

(Jenny et al., 2003)

dgo³⁸⁰ is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

NOT Enhancer of

Statement

Reference

dgo[+]/dgo³⁸⁰ is a non-enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

dgo[+]/dgo³⁸⁰ is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dgo³⁸⁰ is a non-enhancer of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

Suppressor of

Statement

Reference

dgo[+]/dgo³⁸⁰ is a suppressor of abnormal planar polarity phenotype of bdg^GMREP

(Rawls et al., 2007)

NOT Suppressor of

Statement

Reference

dgo[+]/dgo³⁸⁰ is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

dgo[+]/dgo³⁸⁰ is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dgo³⁸⁰/dgo³⁸⁰ is a non-suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of Vang^stbm-6

(Strutt and Strutt, 2007)

dgo³⁸⁰ is a non-suppressor of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

Other

Statement

Reference

Vang^stbm-6, dgo³⁸⁰, pk^pk-sple-13 has abnormal cell polarity | adult stage phenotype

(Strutt et al., 2016)

Vang^stbm-6, dgo³⁸⁰, dsh³, pk^pk-sple-13 has abnormal cell polarity | adult stage phenotype

(Strutt et al., 2016)

CG15283^GD13108, Scer\GAL4^en-e16E, dgo[+]/dgo³⁸⁰, pk[+]/pk^pk-sple-13 has abnormal planar polarity phenotype

(Weber et al., 2012)

Mks1^GD9100, Scer\GAL4^en-e16E, dgo[+]/dgo³⁸⁰ has abnormal planar polarity phenotype

(Weber et al., 2012)

bdg¹⁶⁴, dgo³⁸⁰ has lethal | recessive phenotype

(Rawls et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

dgo³⁸⁰ has ommatidium phenotype, enhanceable by ed[+]/ed^1X5

(Fetting et al., 2009)

Scer\GAL4^hs.2sev, dgo[+]/dgo³⁸⁰, shg^{dCR3h.UAS.sgGFP} has ommatidium phenotype, enhanceable by Vang^stbm-6/Vang[+]

(Mirkovic and Mlodzik, 2006)

Suppressed by

Statement

Reference

dgo³⁸⁰ has wing hair phenotype, suppressible by Scer\GAL4^hh-Gal4/Mmus\Ankrd6^UAS.cJa

(Jones et al., 2014)

dgo³⁸⁰ has eye phenotype, suppressible by Scer\GAL4^hh-Gal4/Mmus\Ankrd6^UAS.cJa

(Jones et al., 2014)

dgo³⁸⁰ has ommatidium phenotype, suppressible by bdg[+]/bdg^GMREP

(Rawls et al., 2007)

dgo³⁸⁰ has ommatidium phenotype, suppressible by bdg¹⁶⁴/bdg[+]

(Rawls et al., 2007)

Enhancer of

Statement

Reference

dgo[+]/dgo³⁸⁰ is an enhancer of wing hair phenotype of CG15283^GD13108, Scer\GAL4^en-e16E

(Weber et al., 2012)

dgo[+]/dgo³⁸⁰ is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, Vang^stbm-6/Vang[+], shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

dgo[+]/dgo³⁸⁰ is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

dgo[+]/dgo³⁸⁰ is an enhancer of wing cell | adult stage | heat sensitive phenotype of shi¹

(Classen et al., 2005)

dgo³⁸⁰ is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, Vang^UAS.cWa

(Jenny et al., 2003)

dgo³⁸⁰ is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

dgo³⁸⁰ is an enhancer of ommatidium phenotype of Scer\GAL4^sev.PM181, stan^UAS.cUa

(Das et al., 2002)

dgo³⁸⁰ is an enhancer of photoreceptor cell R3 | ectopic phenotype of Scer\GAL4^sev.PM181, stan^UAS.cUa

(Das et al., 2002)

dgo³⁸⁰ is an enhancer of photoreceptor cell R4 phenotype of Scer\GAL4^sev.PM181, stan^UAS.cUa

(Das et al., 2002)

NOT Enhancer of

Statement

Reference

dgo[+]/dgo³⁸⁰ is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

dgo[+]/dgo³⁸⁰ is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dgo³⁸⁰ is a non-enhancer of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

Suppressor of

Statement

Reference

dgo[+]/dgo³⁸⁰ is a suppressor of ommatidium phenotype of bdg^GMREP

(Rawls et al., 2007)

NOT Suppressor of

Statement

Reference

dgo[+]/dgo³⁸⁰ is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

dgo[+]/dgo³⁸⁰ is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dgo³⁸⁰/dgo³⁸⁰ is a non-suppressor of wing hair | somatic clone | cell non-autonomous | pupal stage phenotype of Vang^stbm-6

(Strutt and Strutt, 2007)

dgo³⁸⁰ is a non-suppressor of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

Other

Statement

Reference

Vang^stbm-6, dgo³⁸⁰, pk^pk-sple-13 has wing hair phenotype

(Strutt et al., 2016)

Vang^stbm-6, dgo³⁸⁰, dsh³, pk^pk-sple-13 has wing hair phenotype

(Strutt et al., 2016)

CG15283^GD13108, Scer\GAL4^en-e16E, dgo[+]/dgo³⁸⁰, pk[+]/pk^pk-sple-13 has wing hair phenotype

(Weber et al., 2012)

Mks1^GD9100, Scer\GAL4^en-e16E, dgo[+]/dgo³⁸⁰ has wing hair phenotype

(Weber et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Vang^stbm-6, dgo³⁸⁰, pk^pk-sple-13 and dsh³, Vang^stbm-6, dgo³⁸⁰, pk^pk-sple-13 triple and quadruple heterozygotes exhibit mild wing trichome orientation defects in proximal regions.

(Strutt et al., 2016)

dgo³⁸⁰/+ causes wing hair whirls in 44% of flies expressing Mks1^GD9100 under the control of Scer\GAL4^en-e16E.

dgo³⁸⁰/+ causes wing hair whirls in 89% of flies expressing CG15283^GD13108 under the control of Scer\GAL4^en-e16E. The enhancement of the CG15283^GD13108 planar cell polarity (PCP)-phenotype by dgo³⁸⁰ is particularly robust.

(Weber et al., 2012)

ed^1X5 dominantly enhances the phenotype of mis-rotation of ommatidia that is seen in dgo³⁸⁰ animals.

(Fetting et al., 2009)

The ommatidial polarity defects caused by dgo³⁸⁰ are suppressed by one copy of bdg^GMREP or bdg¹⁶⁴.

The ommatidial polarity defects seen in bdg^GMREP homozygotes are dominantly suppressed by dgo³⁸⁰.

(Rawls et al., 2007)

dgo³⁸⁰ Vang^stbm-6/Vang^stbm-6 clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes away from the clone, as occurs with Vang^stbm-6/Vang^stbm-6 single mutant clones in the pupal wing.

dgo³⁸⁰ pk^pk-sple-13/pk^pk-sple-13 clones in the pupal wing (32 hours after puparium formation) do not affect polarity of trichomes in surrounding wild-type tissue.

Clones expressing fz^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^Act5C.PI in a pk^pk-sple-13/pk^pk-sple-13 background result in non-clonal cells pointing their trichomes away from the clone. This effect extends 8-9 cells from the clone boundary. This effect is still seen if the clones are also mutant for dgo³⁸⁰, but in this case the effect only extends 5-6 cells from the clone boundary.

(Strutt and Strutt, 2007)

Both a dgo³⁸⁰/+ and a Vang^stbm-6/+ background enhances the ommatidial rotation phenotype of Scer\GAL4^hs.2sev>shg^{dCR3h.Scer\UAS.T:Avic\GFP-rs} eyes; a dgo³⁸⁰/+, Vang^stbm-6/+ double mutant background further enhances this phenotype.

(Mirkovic and Mlodzik, 2006)

The proportion of symmetrical (R3/R3) ommatidia in the eyes of stan^Scer\UAS.cUa; Scer\GAL4^sev.PM181 flies is significantly enhanced by heterozygosity for dgo³⁸⁰.

(Das et al., 2002)

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\Ankrd6^Scer\UAS.cJa in the posterior compartment of the wing under the control of Scer\GAL4^hh-Gal4 completely rescues the whorl phenotype seen in the wing bristles of dgo³⁸⁰ mutant flies. The whorl phenotype is still observed in the anterior compartment. Expression of Mmus\Ankrd6^Scer\UAS.cJa under the control of Scer\GAL4^hh-Gal4 also rescues the dgo³⁸⁰ eye polarity phenotypes.

(Jones et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

58566

w^*; dgo³⁸⁰; P{UAS-mAnkrd6.J}M6K

58567

w^*; dgo³⁸⁰; P{UAS-mAnkrd6.J}M11S

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

380

(Weber et al., 2012)

Dgo³⁸⁰

(Lee and Adler, 2004)

dgo 380

(Feiguin et al., 2001)

dgo380

(Feiguin et al., 2001)

Name Synonyms

diego380

(Jones et al., 2014)

Secondary FlyBase IDs

References (30)

Report Sections

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