FlyBase Allele Report: Dmel\stan[frz3]

General Information

Symbol

Dmel\stan^frz3

Species

D. melanogaster

Name

FlyBase ID

FBal0143193

Feature type

allele

Associated gene

Dmel\stan

Associated Insertion(s)

Carried in Construct

Also Known As

fmi^frz3

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Rawls and Wolff, 2003.4.28)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage

(Han et al., 2020)

abnormal planar polarity

(Chin and Mlodzik, 2013, Rawls et al., 2007, Rawls and Wolff, 2003, Rawls and Wolff, 2003.4.28)

Phenotype Manifest In

adult thorax

(Chin and Mlodzik, 2013)

leg

(Rawls and Wolff, 2003.4.28)

medulla | P-stage

(Han et al., 2020)

ommatidium

(Chin and Mlodzik, 2013, Fetting et al., 2009, Rawls et al., 2007, Rawls and Wolff, 2003, Rawls and Wolff, 2003.4.28)

thorax

(Rawls and Wolff, 2003.4.28)

wing

(Chin and Mlodzik, 2013, Rawls and Wolff, 2003.4.28)

Detailed Description

Statement

Reference

stan^frz3 flies show planar cell polarity defects in the eyes, wings and thorax.

(Chin and Mlodzik, 2013)

Many stan^frz3 ommatidia mis-rotate; the variance (s.d.) in degree of rotation is greater than in wild type in adult eyes.

(Fetting et al., 2009)

Homozygotes show defects in ommatidial polarity.

(Rawls et al., 2007)

Homozygotes exhibit a range of polarity defects in the eye. 13.9% of ommatidia show polarity defects.

(Rawls and Wolff, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

stan^frz3 has abnormal planar polarity phenotype, enhanceable by fw⁴²

(Chin and Mlodzik, 2013)

stan^frz3 has abnormal planar polarity phenotype, enhanceable by bdg[+]/bdg^GMREP

(Rawls et al., 2007)

stan^frz3 has abnormal planar polarity phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

stan^frz3 has abnormal planar polarity phenotype, enhanceable by Vang^stbm-153

(Rawls and Wolff, 2003)

Enhancer of

Statement

Reference

stan[+]/stan^frz3 is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex1

(Gombos et al., 2015)

stan^frz3 is an enhancer of abnormal planar polarity phenotype of Vang^stbm-153

(Rawls and Wolff, 2003)

stan^frz3 is an enhancer of abnormal planar polarity phenotype of Vang^sev.PR

(Rawls and Wolff, 2003)

Suppressor of

Statement

Reference

stan[+]/stan^frz3 is a suppressor | partially of decreased size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

stan[+]/stan^frz3 is a suppressor | partially of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

stan[+]/stan^frz3 is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

stan[+]/stan^frz3 is a suppressor of visible phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

stan[+]/stan^frz3 is a suppressor of abnormal planar polarity phenotype of bdg^GMREP

(Rawls et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

stan^frz3 has wing phenotype, enhanceable by fw⁴²

(Chin and Mlodzik, 2013)

stan^frz3 has ommatidium phenotype, enhanceable by fw⁴²

(Chin and Mlodzik, 2013)

stan^frz3 has adult thorax phenotype, enhanceable by fw⁴²

(Chin and Mlodzik, 2013)

stan^frz3 has ommatidium phenotype, enhanceable by ed[+]/ed^1X5

(Fetting et al., 2009)

stan^frz3 has ommatidium phenotype, enhanceable by fred[+]/fred^H24

(Fetting et al., 2009)

stan^frz3 has ommatidium phenotype, enhanceable by bdg[+]/bdg^GMREP

(Rawls et al., 2007)

stan^frz3 has ommatidium phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

stan^frz3 has ommatidium phenotype, enhanceable by Vang^stbm-153

(Rawls and Wolff, 2003)

Enhancer of

Statement

Reference

stan^frz3 is an enhancer of adult mushroom body alpha-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

stan^frz3 is an enhancer of ommatidium phenotype of Vang^stbm-153

(Rawls and Wolff, 2003)

stan^frz3 is an enhancer of ommatidium phenotype of Vang^sev.PR

(Rawls and Wolff, 2003)

NOT Enhancer of

Statement

Reference

stan[+]/stan^frz3 is a non-enhancer of adult mushroom body beta-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

Suppressor of

Statement

Reference

stan[+]/stan^frz3 is a suppressor | partially of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

stan[+]/stan^frz3 is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

stan[+]/stan^frz3 is a suppressor of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

stan[+]/stan^frz3 is a suppressor of ommatidium phenotype of bdg^GMREP

(Rawls et al., 2007)

Other

Statement

Reference

Vang^stbm-153, stan^frz3 has photoreceptor neuron phenotype

(Rawls and Wolff, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of stan^frz3 strongly enhances the axonal projection defects seen in the αlobes of DAAM^Ex1 mutant mushroom bodies. The β lobe defects are not significantly enhanced.

(Gombos et al., 2015)

fw⁴² enhances the planar cell polarity defects seen in stan^frz3 flies in all tissues examined (eyes, wings and thorax).

(Chin and Mlodzik, 2013)

stan^frz3/+ significantly suppresses both the eye and wing defects induced by the overexpression of dgo^Scer\UAS.cFa under the control of Scer\GAL4^hs.2sev.

(Weber et al., 2012)

ed^1X5 dominantly enhances the phenotype of mis-rotation of ommatidia that is seen in stan^frz3 animals.

fred^H24 dominantly enhances the phenotype of mis-rotation of ommatidia that is seen in stan^frz3 animals.

(Fetting et al., 2009)

The ommatidial polarity defects caused by stan^frz3 are enhanced by one copy of bdg^GMREP.

Homozygosity for bdg¹⁶⁴ enhances the ommatidial polarity defects caused by homozygosity for stan^frz3.

The ommatidial polarity defects seen in bdg^GMREP homozygotes are dominantly suppressed by stan^frz3.

(Rawls et al., 2007)

32.9% of ommatidia in stan^frz3/stan^frz3, Vang^stbm-153/+ animals exhibit polarity defects in the eye. 63.7% of ommatidia in stan^frz3/stan^frz3, Vang^stbm-153/Vang^stbm-153 animals exhibit polarity defects in the eye. They also have missing photoreceptor cells.

(Rawls and Wolff, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6967

stan^frz3

Notes on Origin

Discoverer

D. Gubb

(Rawls and Wolff, 2003.4.28)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fmi^frz3

(Han et al., 2020, Gombos et al., 2015, Chin and Mlodzik, 2013, Fetting et al., 2009, Rawls et al., 2007, Rawls and Wolff, 2003)

stan^frz3

(Weber et al., 2012, Pataki et al., 2010)

stan^fz3

(Lee et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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