FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\γTub23CA15-2
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General Information
Symbol
Dmel\γTub23CA15-2
Species
D. melanogaster
Name
FlyBase ID
FBal0147072
Feature type
allele
Associated gene
Dmel\γTub23C
Associated Insertion(s)
Carried in Construct
Also Known As
γ-tub23CA15-2
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Vázquez et al., 2008)
Mutagen
ethyl methanesulfonate
(Ferro, 2002.12)
Progenitor genotype
Cytology
Description

Amino acid replacement: W104term.

(Vázquez et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,973,487..2,973,487 [+]
Nucleotide change:

G2973487A

Amino acid change:

W104term | gammaTub23C-PA

Reported amino acid change:

W104term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Vázquez et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      γTub23CA15-2/Df(2L)ED4651 third instar larval adipocytes do not show defects in the normal perinuclear distribution of microtubules.

      (Sun et al., 2019)

      Almost all γTub23CA15-2/γTub23CA14-9 axonal microtubules (Eb1 comets) travel in an anterograde direction (similar to what is seen in control class IV da neurons) in third instar larvae.

      (Arthur et al., 2015)

      γTub23CA15-2 heterozygous larval ddaE neurons show decreased growing microtubules within dendrites 8h and 24h after axotomy and show a decrease in the proportion of dendrites persisting 18h after consecutive axotomy and dendrite severance (i.e. axotomy-8h-dendrite severance-18h), as compared to similarly injured neurons in controls; this decrease in neurites does not occur upon a 24h interval between axotomoy and dendrite severance. Uninjured neurons do not show changes in growing microtubules within dendrites, as compared to controls.

      γTub23CA15-2 heterozygous larval ddaE neurons do not show changes in axon regeneration at 48h upon proximal axotomy, as compared to similarly injured control neurons.

      γTub23CA15-2 heterozygous larval ddaC neurons show a normal dendrite branch trimming after distal axon severing.

      (Chen et al., 2012)

      3% of γTub23CA6-2/γTub23CA15-2 animals survive to eclosion, but all quickly become stuck in the food medium.

      25% of γTub23CA14-9/γTub23CA15-2 animals survive to eclosion.

      (Vázquez et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      γTub23Cbmps1/γTub23CA15-2 has lethal phenotype, suppressible | partially by Grip91su(Pl)

      (Vázquez et al., 2008)
      NOT suppressed by
      Statement
      Reference

      γTub23CA6-2/γTub23CA15-2 has lethal phenotype, non-suppressible by Grip91su(Pl)

      (Vázquez et al., 2008)

      Df(2L)JS17/γTub23CA15-2 has lethal phenotype, non-suppressible by Grip91su(Pl)

      (Vázquez et al., 2008)

      Df(2L)3G/γTub23CA15-2 has lethal phenotype, non-suppressible by Grip91su(Pl)

      (Vázquez et al., 2008)
      Suppressor of
      Statement
      Reference

      gammaTub23C[+]/γTub23CA15-2 is a suppressor | partially of abnormal neuroanatomy | P-stage phenotype of Efa6GX6w-/Efa612

      (Bu et al., 2021)
      Other
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      γTub23CA14-9/γTub23CA15-2 is a non-enhancer of microtubule | third instar larval stage phenotype of nudE39A

      (Arthur et al., 2015)
      Suppressor of
      Statement
      Reference

      gammaTub23C[+]/γTub23CA15-2 is a suppressor | partially of embryonic/larval sensory neuron | P-stage phenotype of Efa6GX6w-/Efa612

      (Bu et al., 2021)

      gammaTub23C[+]/γTub23CA15-2 is a suppressor | partially of dendrite | P-stage phenotype of Efa6GX6w-/Efa612

      (Bu et al., 2021)
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduced viability of γTub23CA14-9/γTub23CA15-2 flies is not further reduced by brm2/+.

      (Vázquez et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: cn1 bw1 chromosome.

      (Ferro, 2002.12)
      Comments
      Comments

      One of n alleles recovered.

      (Ferro, 2002.12)

      Allelic series (in order of decreasing activity): γTub23CA14-9 > γTub23CA6-2 > γTub23CA15-2 = Df(2L)JS17 = Df(2L)3G > γTub23CPl-2.

      (Vázquez et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      l(2)23CeA15-2
      (Vázquez et al., 2008)
      γ-tub23CA15-2
      (Tang et al., 2020, Zheng et al., 2020)
      γTub23CA15-2
      (Kumar et al., 2026, Sun et al., 2019, Arthur et al., 2015, Nguyen et al., 2014, Chen et al., 2012, Vázquez et al., 2008)
      γTubulin23CA15-2
      (Segura et al., 2025)
      γtub23CA15-2
      (Zhang et al., 2024, Bu et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (12)