FlyBase Allele Report: Dmel\γTub23C[A14-9]

General Information

Symbol

Dmel\γTub23C^A14-9

Species

D. melanogaster

Name

FlyBase ID

FBal0147073

Feature type

allele

Associated gene

Dmel\γTub23C

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Vázquez et al., 2008)

Mutagen

ethyl methanesulfonate

(Ferro, 2002.12)

Progenitor genotype

Cytology

Description

Amino acid replacement: R217H.

(Vázquez et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:2,973,826..2,973,826 [+]

Nucleotide change:

G2973826A

Amino acid change:

R217H | gammaTub23C-PA

Reported amino acid change:

R217H

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Vázquez et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with γTub23C^bmps1)

(Vázquez et al., 2008)

lethal (with γTub23C^Pl-2)

(Vázquez et al., 2008)

lethal | recessive

(Ferro, 2002.12)

visible (with Df(2L)3G)

(Vázquez et al., 2008)

Phenotype Manifest In

wing (with Df(2L)3G)

(Vázquez et al., 2008)

Detailed Description

Statement

Reference

Almost all γTub23C^A15-2/γTub23C^A14-9 axonal microtubules (Eb1 comets) travel in an anterograde direction (similar to what is seen in control class IV da neurons) in third instar larvae.

(Arthur et al., 2015)

83% of γTub23C^A14-9/Df(2L)3G animals survive to eclosion.

70% of γTub23C^A14-9/Df(2L)JS17 animals survive to eclosion.

65% of γTub23C^A14-9/γTub23C^A6-2 animals survive to eclosion.

25% of γTub23C^A14-9/γTub23C^A15-2 animals survive to eclosion.

(Vázquez et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Df(2L)3G/γTub23C^A14-9 has visible phenotype, enhanceable by brm[+]/brm²

(Vázquez et al., 2008)

NOT suppressed by

Statement

Reference

γTub23C^A14-9/γTub23C^Pl-2 has lethal phenotype, non-suppressible by Grip91^su(Pl)

(Vázquez et al., 2008)

γTub23C^bmps1/γTub23C^A14-9 has lethal phenotype, non-suppressible by Grip91^su(Pl)

(Vázquez et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Df(2L)3G/γTub23C^A14-9 has wing phenotype, enhanceable by brm[+]/brm²

(Vázquez et al., 2008)

NOT Enhancer of

Statement

Reference

γTub23C^A14-9/γTub23C^A15-2 is a non-enhancer of microtubule | third instar larval stage phenotype of nudE^39A

(Arthur et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

γTub23C^A15-2/γTub23C^A14-9 does not affect the amount of axonal microtubule retrograde transport seen in nudE^39A/nudE^39A class IV da neurons in third instar larvae.

(Arthur et al., 2015)

The reduced viability of γTub23C^A14-9/γTub23C^A6-2, γTub23C^A14-9/γTub23C^A15-2 and γTub23C^A14-9/Df(2L)3G flies is not further reduced by brm²/+.

The held-out wings phenotype of γTub23C^A14-9/Df(2L)3G flies is enhanced by brm²/+, but the expressivity of pearl-like structures in the wings is not enhanced.

(Vázquez et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

γTub23C^Pl-2

(Vázquez et al., 2008)

γTub23C^bmps1

(Vázquez et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

7041

γTub23C^A14-9 cn¹ bw¹/CyO

Notes on Origin

Discoverer

Induced on: cn¹ bw¹ chromosome.

(Ferro, 2002.12)

Comments

One of n alleles recovered.

(Ferro, 2002.12)

Allelic series (in order of decreasing activity): γTub23C^A14-9 > γTub23C^A6-2 > γTub23C^A15-2 = Df(2L)JS17 = Df(2L)3G > γTub23C^Pl-2.

(Vázquez et al., 2008)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

l(2)23Ce^A14-9

(Vázquez et al., 2008)

γ-tub23C^A14-9

(Tang et al., 2020)

γTub23C^A14-9

(Arthur et al., 2015, Nguyen et al., 2014, Vázquez et al., 2008)

γTubulin23C^A14-9

(Segura et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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