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General Information
Symbol
Dmel\PakUAS.Tag:MYC
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Ang
FlyBase ID
FBal0147694
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-pak
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of Tag:MYC tagged Pak cDNA is under the control of UASt sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4OK107 results in axon growth and guidance defects in the mushroom body.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Enhancer of
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Enhancer of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Expression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PU at 29[o]C rescues the defects in the dorsal surface of the cuticle seen in Pak14 Pak376A double mutants, but does not effectively suppress the head hole phenotype.

Overexpression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu enhances the longitudinal axon guidance and pCC/MP1 defects seen in transheterozygous sli1, robo5 mutants. An average of 6.1 defects are seen per animal. 55% of segments (calculated as number of defects/segments) show defects. The combination of heterozygous sli2 and pan-neural overexpression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu leads to longitudinal axon ectopic midline crossing defects. An average of 1.2 defects are seen per animal, and an average of 11% of segments have defects.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Scer\GAL4SG18.1; PakScer\UAS.T:Hsap\MYC (gives expression in olfactory neurons, but not in the brain) rescues the development of most glomeruli in Pak11/Pak6 flies.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
PakScer\UAS.T:Hsap\MYC
PakUAS.Tag:MYC
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Ang
Secondary FlyBase IDs
    References (5)