Expression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PU at 29[o]C rescues the defects in the dorsal surface of the cuticle seen in Pak14 Pak376A double mutants, but does not effectively suppress the head hole phenotype.
Overexpression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu enhances the longitudinal axon guidance and pCC/MP1 defects seen in transheterozygous sli1, robo5 mutants. An average of 6.1 defects are seen per animal. 55% of segments (calculated as number of defects/segments) show defects. The combination of heterozygous sli2 and pan-neural overexpression of PakScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PLu leads to longitudinal axon ectopic midline crossing defects. An average of 1.2 defects are seen per animal, and an average of 11% of segments have defects.