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General Information
Symbol
Dmel\tsrS3A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0177370
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-TsrS3A, UAS-tsr.S3A
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a constitutively active form of tsr (carries the amino acid replacement S3A).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of tsrS3A.Scer\UAS under the control of Scer\GAL4GMR13F02 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in enhanced memory after conditioning in an olfactory conditioning assay.

Conditional expression of tsrS3A.Scer\UAS under the control of Scer\GAL4tub.PU (GAL80ts has been used to limit expression to the adult stage) results in increased sensitivity to ethanol-induced sedation in adult flies compared to controls.

Expression of tsrS3A.Scer\UAS under the control of Scer\GAL4Act.PU in clones results in mild-mistargeting of Or59c-expressing olfactory receptor neurons in 20% of adult brains.

Expression of tsrS3A.Scer\UAS under the control of Scer\GAL4elav.PU (using tub-Gal80[ts] to limit the expression to the adult stage) significantly enhances 3 hr memory of adult flies in an aversive olfactory assay compared to controls.

Overexpression of tsrS3A.Scer\UAS in mushroom body neurons under the control of Scer\GAL4OK107 does not result in gross axon or cell proliferation defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

Scer\GAL4ey-OK107/tsrS3A.UAS is a suppressor of adult mushroom body & axon | somatic clone phenotype of ssh1-11

Scer\GAL4ey-OK107/tsrS3A.UAS is a suppressor of antennal lobe & axon | somatic clone phenotype of ssh1-11

Scer\GAL4ey-OK107/tsrS3A.UAS is a suppressor of optic lobe neuron & axon | somatic clone phenotype of ssh1-11

Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of scribKK106065 does not affect the memory performance of flies expressing tsrS3A.Scer\UAS under the control of Scer\GAL4GMR13F02 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage).

Expression of tsrS3A.Scer\UAS under the control of Scer\GAL4NP7175 significantly suppresses the axon growth phenotype seen in the α/β mushroom body lobes of sickA384/sickΔ mutants.

Expression of tsrS3A.Scer\UAS under the control of Scer\GAL4Act.PU reduces the axon mistargeting phenotype seen in Or59c-expressing psidin1 olfactory receptor neuron clones by 14%.

The axon growth and guidance defects seen in homozygous ssh1-11 adult mushroom body clones (which are generated as neuroblast clones in newly hatched larvae) are almost completely suppressed by co-expression of tsrS3A.Scer\UAS under the control of Scer\GAL4OK107. The axon growth defects seen in neuroblast clones of optic lobe and antennal lobe contralateral projection neurons are partially suppressed by co-expression of tsrS3A.Scer\UAS under the control of Scer\GAL4OK107.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Expression of tsrS3A.Scer\UAS under the control of Scer\GAL4OK107 partially rescues the cell proliferation defects seen in homozygous tsrN96A adult mushroom body clones (which are generated as neuroblast clones in newly hatched larvae); only γ and α/β neurons are generated in these clones. Expression of tsrS3A.Scer\UAS under the control of Scer\GAL4OK107 partially rescues the axon growth defects seen in single cell tsrN96A γ neuron clones in the mushroom body.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
tsrS3A.Scer\UAS
tsrS3A.UAS
Name Synonyms
Secondary FlyBase IDs
    References (9)