FlyBase Allele Report: Dmel\sl[9]

General Information

Symbol

Dmel\sl⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0151485

Feature type

allele

Associated gene

Dmel\sl

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Mankidy et al., 2003)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A.

(Thackeray, 2006.5.24)

Amino acid replacement: W54term.

(Thackeray, 2006.5.24)

Amino acid replacement: ?54term.

(Mankidy et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:16,350,746..16,350,746 [+]

Nucleotide change:

G16350746A

Reported nucleotide change:

G?A

Amino acid change:

W54term | sl-PA

Reported amino acid change:

W54term

Comment:

TGG to TAG

(Thackeray, 2006.5.24, Mankidy et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Wing blade area is reduced by approximately 20% in homozygous sl⁹ mutant males compared to wild type. The area of the eye is also reduced by about 8% compared to controls. sl⁹ mutant flies also show a 9% reduction in the number of ommatidia (sl⁹ mutant eyes have on average 698 ommatidia compared to 765 in wild type). sl⁹ mutant eyes have an increased number of R7 photoreceptors per ommatidium, but the combined area of the R1-R6 rhabdomeres is reduced by on average 15.2% compared to heterozygous controls indicating a reduced cell size.

Two day old homozygous sl⁹ mutant females are approximately 8% lighter than their heterozygous siblings. Pupal length and weight of stage 12-15 pupae do not differ from controls.

(Murillo-Maldonado et al., 2011)

In the eyes of sl⁹ homozygous flies, ~9% of ommatidia are misrotated and over half have between one and three extra R7 cells extra photoreceptors. In addition, interommatidial bristles are sometimes misplaced or supernumerary.

(Schlesinger et al., 2004)

58.9% of ommatidia have extra R7 cells in homozygous females. The length of the wing is approximately 80% normal length in homozygous females, and ectopic wing veins are seen. sl⁸/sl⁹ and sl⁷/sl⁹ females have wing lengths indistinguishable from each other and typical of sl mutant homozygotes. sl⁸/sl⁹ females have extra R7 cells in 45.9% of ommatidia. sl⁷/sl⁹ females have extra R7 cells in 7.8% of ommatidia.

(Mankidy et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sl⁹ has increased cell number | adult stage phenotype, enhanceable by Itpr^B4/Itp-r83A[+]

(Murillo-Maldonado et al., 2011)

sl⁹ has abnormal planar polarity | recessive phenotype, enhanceable by aos^Δ7/argos[+]

(Schlesinger et al., 2004)

NOT Enhanced by

Statement

Reference

sl⁹ has abnormal size | adult stage phenotype, non-enhanceable by Egfr[+]/Egfr^f2

(Murillo-Maldonado et al., 2011)

sl⁹ has abnormal size | adult stage phenotype, non-enhanceable by drk[+]/drk^e0A

(Murillo-Maldonado et al., 2011)

sl⁹ has abnormal size | adult stage phenotype, non-enhanceable by Itpr^B4/Itp-r83A[+]

(Murillo-Maldonado et al., 2011)

sl⁹ has increased cell number | adult stage phenotype, non-enhanceable by InR[+]/InR^93Dj-4

(Murillo-Maldonado et al., 2011)

sl⁹ has abnormal size | adult stage phenotype, non-enhanceable by InR[+]/InR^E19

(Murillo-Maldonado et al., 2011)

sl⁹ has abnormal size | adult stage phenotype, non-enhanceable by Akt1[+]/Akt¹

(Murillo-Maldonado et al., 2011)

Suppressed by

Statement

Reference

sl⁹ has abnormal planar polarity | recessive phenotype, suppressible by S[+]/S^IIN

(Schlesinger et al., 2004)

sl⁹ has abnormal planar polarity | recessive phenotype, suppressible | partially by Egfr[+]/Egfr^f2

(Schlesinger et al., 2004)

Suppressor of

Statement

Reference

sl⁹/sl⁹ is a suppressor of abnormal planar polarity | recessive phenotype of ru^PLLb

(Schlesinger et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

sl⁹ has photoreceptor cell R7 | adult stage phenotype, enhanceable by Itpr^B4/Itp-r83A[+]

(Murillo-Maldonado et al., 2011)

sl⁹ has photoreceptor cell R7 | increased number phenotype, enhanceable by aos^Δ7/argos[+]

(Schlesinger et al., 2004)

sl⁹ has ommatidium phenotype, enhanceable by aos^Δ7/argos[+]

(Schlesinger et al., 2004)

sl⁹ has interommatidial bristle phenotype, enhanceable by aos^Δ7/argos[+]

(Schlesinger et al., 2004)

NOT Enhanced by

Statement

Reference

sl⁹ has wing blade phenotype, non-enhanceable by Egfr[+]/Egfr^f2

(Murillo-Maldonado et al., 2011)

sl⁹ has wing blade phenotype, non-enhanceable by drk[+]/drk^e0A

(Murillo-Maldonado et al., 2011)

sl⁹ has wing blade phenotype, non-enhanceable by Itpr^B4/Itp-r83A[+]

(Murillo-Maldonado et al., 2011)

sl⁹ has photoreceptor cell R7 | adult stage phenotype, non-enhanceable by InR[+]/InR^93Dj-4

(Murillo-Maldonado et al., 2011)

sl⁹ has wing blade phenotype, non-enhanceable by InR[+]/InR^E19

(Murillo-Maldonado et al., 2011)

sl⁹ has wing blade phenotype, non-enhanceable by Akt1[+]/Akt¹

(Murillo-Maldonado et al., 2011)

Suppressed by

Statement

Reference

sl⁹ has photoreceptor cell R7 | increased number phenotype, suppressible | partially by Egfr[+]/Egfr^f2

(Schlesinger et al., 2004)

sl⁹ has ommatidium phenotype, suppressible | partially by Egfr[+]/Egfr^f2

(Schlesinger et al., 2004)

sl⁹ has photoreceptor cell R7 | increased number phenotype, suppressible | partially by S[+]/S^IIN

(Schlesinger et al., 2004)

sl⁹ has ommatidium phenotype, suppressible | partially by S[+]/S^IIN

(Schlesinger et al., 2004)

sl⁹ has interommatidial bristle phenotype, suppressible by Egfr[+]/Egfr^f2

(Schlesinger et al., 2004)

sl⁹ has interommatidial bristle phenotype, suppressible by S[+]/S^IIN

(Schlesinger et al., 2004)

Suppressor of

Statement

Reference

sl⁹/sl⁹ is a suppressor of eye photoreceptor cell phenotype of ru^PLLb

(Schlesinger et al., 2004)

sl⁹/sl⁹ is a suppressor of ommatidium phenotype of ru^PLLb

(Schlesinger et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of InR^E19 does not enhance the reduction in wing blade area seen in homozygous sl⁹ males.

One copy of Akt1¹ does not enhance the reduction in wing blade area seen in homozygous sl⁹ males.

One copy of Egfr^f2 does not enhance the reduction in wing blade area seen in homozygous sl⁹ males.

One copy of drk^e0A does not enhance the reduction in wing blade area seen in homozygous sl⁹ males.

One copy of Itp-r83A^B4 does not enhance the reduction in wing blade area seen in homozygous sl⁹ males.

One copy of InR^93Dj-4 does not enhance the increase in R7 photoreceptor cells per ommatidium that is seen in sl⁹ mutant males.

One copy of Itp-r83A^B4 enhances the percentage of sl⁹ mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

(Murillo-Maldonado et al., 2011)

Misrotation of ommatidia and extra R7 photoreceptor due to sl⁹/sl⁹ are almost completely suppressed by S^IIN/+ or Egfr^f2/+, but are enhanced by argos^Δ7/+.

(Schlesinger et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sl¹

(Mankidy et al., 2003)

Rescued by

sl⁹ is rescued by sl^+tX10

(Mankidy et al., 2003)

sl⁹ is rescued by sl^X10-P1035V

(Mankidy et al., 2003)

Partially rescued by

sl⁹ is partially rescued by sl^UAS.cSa/Scer\GAL4^sca-537.4

(Schlesinger et al., 2004)

sl⁹ is partially rescued by sl^X10-P1035A

(Mankidy et al., 2003)

Comments

sl^Scer\UAS.cSa; Scer\GAL4^sca-537.4 largely rescues the eye phenotypes seen in sl⁹/sl⁹ homozygotes: most ommatidia have normal numbers of photoreceptor cells and only a small proportion have rotation defects.

(Schlesinger et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sl⁹

(Murillo-Maldonado et al., 2011, Schlesinger et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (4)

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