FlyBase Allele Report: Dmel\pita[3]

General Information

Symbol

Dmel\pita³

Species

D. melanogaster

Name

FlyBase ID

FBal0154754

Feature type

allele

Associated gene

Dmel\pita

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Laundrie et al., 2003)

Mutagen

ethyl methanesulfonate

(Laundrie et al., 2003)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q315term.

(Laundrie et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:23,550,256..23,550,256 [-]

Nucleotide change:

C23550256T

Amino acid change:

Q315term | pita-PA; Q255term | pita-PB

Reported amino acid change:

Q315term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Laundrie et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Laundrie et al., 2003)

melanotic mass phenotype | larval stage | recessive

(Laundrie et al., 2003)

some die during larval stage | recessive

(Laundrie et al., 2003)

Phenotype Manifest In

egg chamber | germline clone

(Laundrie et al., 2003)

follicle cell | germline clone

(Laundrie et al., 2003)

imaginal disc

(Laundrie et al., 2003)

larval tracheal system

(Laundrie et al., 2003)

nurse cell & nucleus | germ-line clone

(Laundrie et al., 2003)

Detailed Description

Statement

Reference

pita³ homozygotes die as larvae with melanotic tumors, underdeveloped imaginal discs, and tracheal defects. 56% of stage 6-9 pita³ germ-line clone egg chambers lack nurse cell nuclei completely and many have a thickened follicle cell layer.

(Laundrie et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

pita⁰¹⁸⁶²

(Laundrie et al., 2003)

pita⁰⁸⁸⁵⁹

(Laundrie et al., 2003)

pita^k05606

(Laundrie et al., 2003)

pita⁰²¹³²

(Laundrie et al., 2003)

Rescued by

pita³ is rescued by pita^hs.PL

(Laundrie et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

63816

cn¹ bw¹ pita³ speck¹/SM6#16

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

pita3

(McCall, 2014.7.9)

pita³

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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