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General Information
Symbol
Dmel\chbUAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0159409
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of chb tagged with GFP.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of chbScer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PF results in a rough eye phenotype.

Expression of chbScer\UAS.T:Avic\GFP in post-mitotic neurons under the control of Scer\GAL4elav.PLu results in abnormal longitudinal fascicles, with deflections in pathfinding and some segments missing fascicles, primarily in the outer fascicle.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

A CLIP-190c02410 mutant background suppresses the rough eye phenotype found when chbScer\UAS.T:Avic\GFP is expressed under the control of Scer\GAL4GMR.PF.

Co-expression of AblScer\UAS.cFa enhances the chbScer\UAS.T:Avic\GFP mutant eye phenotype when both transgenes are expressed under the control of Scer\GAL4GMR.PF.

Knockdown of zip through coexpression of zipGD1566 with chbScer\UAS.T:Avic\GFP in the developing eye under the control of Scer\GAL4GMR.PF leads to a severe eye phenotype.

Co-expression of mspsd03376 with chbScer\UAS.T:Avic\GFP, both under the control of Scer\GAL4GMR.PF, leads to a strong suppression of the chbScer\UAS.T:Avic\GFP rough eye phenotype.

Co-expression of mspsP with chbScer\UAS.T:Avic\GFP, both under the control of Scer\GAL4GMR.PF, leads to a strong enhancement of the chbScer\UAS.T:Avic\GFP rough eye phenotype.

Co-expression of mspsc03283 with chbScer\UAS.T:Avic\GFP, both under the control of Scer\GAL4GMR.PF, leads to a strong enhancement of the chbScer\UAS.T:Avic\GFP rough eye phenotype.

Expression of chbScer\UAS.T:Avic\GFP in post-mitotic neurons under the control of Scer\GAL4elav.PLu in a Df(3R)Exel7328 heterozygous background leads to severe defects in longitudinal axon fascicle formation, with significantly higher penetrance than in either single mutant.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of chbScer\UAS.T:Avic\GFP in hemocytes under the control of Scer\GAL4srp.Hemo rescues microtubule arm formation in chb2 mutants. In addition, expression of chbScer\UAS.T:Avic\GFP restores contact repulsion between hemocytes resulting in wild-type levels of contact time between cells.

The ectopic crossing of the midline by central nervous system axons that is seen in chb2/chb4 embryos is rescued by expression of chbScer\UAS.T:Avic\GFP under the control of Scer\GAL4elav.PLu.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
chbScer\UAS.T:Avic\GFP
chbUAS.GFP
Name Synonyms
Secondary FlyBase IDs
    References (3)