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General Information
Symbol
Dmel\zipGD1566
Species
D. melanogaster
Name
FlyBase ID
FBal0210938
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of zipGD1566 under the control of Scer\GAL4hth-GETDB in the larval antennal disc leads to disorganization and a breakdown of the field boundary at the A1 fold, in contrast to controls, and mislocalized cells are maintained and integrated in the epithelial sheet.

Eye-antennal disc clones expressing zipGD1566 under the control of Scer\GAL4tub.PU exhibit a small reduction in size as compared to wild type clones, along with some defects in differentiation and cell morphology.

Expression of zipGD1566 lessens the invasiveness of Ras85DV12.Scer\UAS scrib1 tumours and improves pupation rate.

Flies expressing zipGD1566 under the control of Scer\GAL4Abd-B-LDN show partial rotation of the male genitalia.

Expression of zipGD1566 under the control of Scer\GAL4Act.PU in clones in the eye disc results in differentiation defects without inducing a cell invasion phenotype.

Expression under the control of Scer\GAL41407 results in an extreme increase in neuroblast size in the larval brain, without loss of neuroblasts.

Expression under the control of Scer\GAL41407 results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Expression under the control of Scer\GAL41407 results in extreme defects in the shape of neuroblasts in the larval brain.

Adults expressing zipGD1566 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in adult/pharate lethality.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of zipGD1566 suppresses the small clone size, differentiation and cell morphology defects seen in eye-antennal disc clones expressing RhoGEF2RE.Scer\UAS under the control of Scer\GAL4tub.PU.

Co-expression of zipGD1566 suppresses the formation of undifferentiated clonal masses and partially suppresses the reduction of differentiation seen in eye-antennal disc clones expressing both RhoGEF2RE.Scer\UAS and RafScer\UAS.F179 under the control of Scer\GAL4tub.PU, and also suppresses the developmental delay shown by larvae containing these clones.

Co-expression of zipGD1566 fails to suppress the ectopic differentiation of seen in eye-antennal disc clones expressing RafScer\UAS.F179 under the control of Scer\GAL4tub.PU.

The cell invasion phenotype (mislocalisation to the optic stalk) shown by sds22Δ2.8 eye disc cells is suppressed if the cells are also expressing zipGD1566 under the control of Scer\GAL4Act.PU.

Knockdown of zip through coexpression of zipGD1566 with chbScer\UAS.T:Avic\GFP in the developing eye under the control of Scer\GAL4GMR.PF leads to a severe eye phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
zipGD1566
zipperGD1566
Name Synonyms
Secondary FlyBase IDs
    References (15)