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General Information
Symbol
Dmel\Tcs3f01978
Species
D. melanogaster
Name
FlyBase ID
FBal0161348
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
PBac{WH}Tcs3f01978
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Compared to wild type (pupate around day 5, eclose around day 10), Tcs3f01978/Df(3L)ED220 exhibit an extended larval period prior to lethality (viability: 88% at day 8, 15% at day 16) and have melanotic masses ('black spots': 16% at day 8, 30% at day 16); larvae are small and unable to dig into food.

Compared to control Tcs3f01978/+ heterozygotes, Tcs3f01978/Df(3L)ED220 larval hemolymph has an overrepresentation of lamellocytes and second instar larvae have overgrown anterior lymph gland lobes.

Most Tcs3f01978/Df(3L)ED220 third instar larvae are missing imaginal discs and have a slightly smaller CNS; optic lobes are strongly reduced in size, while the ventral nerve cord is less affected.

Tcs3f01978/Df(3L)ED220 have significantly smaller salivary glands, salivary gland cell size, and body wall musculature (length of ventral longitudinal muscles 1 and 2) compared to both Tcs31A13/Df(3L)ED220 and wild type larvae.

Homozygous Tcs3f01978 mutant larvae are smaller than wild-type animals. The mutants do not pupariate and die at larval stages.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)