FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Arf6T27N.UAS
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General Information
Symbol
Dmel\Arf6T27N.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0176396
Feature type
allele
Associated gene
Dmel\Arf6
Associated Insertion(s)
Carried in Construct
P{UAS-Arf6.T27N}
Also Known As
UAS-Arf6DN
Key Links
Transgenic product class
missense_variant
(Chen et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chen et al., 2003)
Mutagen
in vitro construct
(Onel et al., 2004, Chen et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Arf6.T27N}
Cytology
Description

Construct: Amino acid replacement: T27N.

(Chen et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Arf6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Arf51FT27N.Scer\UAS in the retina under the control of Scer\GAL4GMR.PF results in patterning defects.

      (Johnson et al., 2011)

      About 15% of stage 16 Arf51FT27N.Scer\UAS; Scer\GAL4rho.PL embryos have ventral cords with reduced or missing commissures.

      (Onel et al., 2004)

      When Arf51FT27N.Scer\UAS is driven by Scer\GAL4kirre-rP298, myoblast fusion is severely disrupted throughout the internal layer of somatic mesoderm in the embryo, although external muscle fibres are formed in their characteristic position.

      (Chen et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Arf51FT27N.Scer\UAS has no effect on the overproliferation phenotype seen in Scer\GAL4en-e16E conuScer\UAS.T:Uuuu\Myr5,T:Zzzz\FLAG wing discs.

      (Neisch et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      ARF6T27N
      (Chen et al., 2003)
      Arf51FT27N.Scer\UAS
      Arf51FT27N.UAS
      Arf6T27N.UAS
      arf6DN
      (Onel et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)