FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\zipUAS.mGFP6
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General Information
Symbol
Dmel\zipUAS.mGFP6
Species
D. melanogaster
Name
FlyBase ID
FBal0177086
Feature type
allele
Associated gene
Dmel\zip
Associated Insertion(s)
Carried in Construct
P{UAS-zip.GFP}
Key Links
Transgenic product class
wild_type
(Barros et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Barros et al., 2003)
Mutagen
in vitro construct
(Barros et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-zip.GFP}
Cytology
Description

UASt regulatory sequences drive expression of an zip tagged with mGFP6.

(Barros et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
zip
Tagged with
mGFP6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4da.G32/zipUAS.mGFP6 rescues zip3

      (Okumura et al., 2010)

      zipUAS.mGFP6/Scer\GAL4wg.PM rescues zip3

      (Okumura et al., 2010)

      zipUAS.mGFP6/Scer\GAL4wg.PM rescues zip4

      (Okumura et al., 2010)
      Partially rescues

      Scer\GAL4how-24B/zipUAS.mGFP6 partially rescues zip3

      (Okumura et al., 2010)

      zipUAS.mGFP6/Scer\GAL4NP3392 partially rescues zip3

      (Okumura et al., 2010)

      zipUAS.mGFP6/Scer\GAL448Y partially rescues zip3

      (Okumura et al., 2010)

      Scer\GAL4NP1522/zipUAS.mGFP6 partially rescues zip3

      (Okumura et al., 2010)

      zipUAS.mGFP6/Scer\GAL4VP16.mat.αTub67C partially rescues zip1

      (Barros et al., 2003)
      Fails to rescue

      Scer\GAL4NP221/zipUAS.mGFP6 fails to rescue zip3

      (Okumura et al., 2010)

      Scer\GAL4tey-5053A/zipUAS.mGFP6 fails to rescue zip3

      (Okumura et al., 2010)

      Scer\GAL4NP5021/zipUAS.mGFP6 fails to rescue zip3

      (Okumura et al., 2010)

      Scer\GAL4drm.7.1/zipUAS.mGFP6 fails to rescue zip3

      (Okumura et al., 2010)

      Scer\GAL4byn-Gal4/zipUAS.mGFP6 fails to rescue zip3

      (Okumura et al., 2010)

      Scer\GAL4elav-C155/zipUAS.mGFP6 fails to rescue zip3

      (Okumura et al., 2010)

      zipUAS.mGFP6/Scer\GAL4wg.PM fails to rescue zip3

      (Okumura et al., 2010)
      Comments

      zipScer\UAS.T:Avic\GFP driven by Scer\GAL4da.G32 rescues the loss of rotation in the proventriculus and anterior midgut seen in zip3 homozygotes.

      zipScer\UAS.T:Avic\GFP driven by the circular visceral muscle drivers Scer\GAL4how-24B, Scer\GAL4Gap1-NP3392, Scer\GAL448Y or Scer\GAL4NetB-NP1522 partially rescues the loss of rotation in the proventriculus and anterior midgut seen in zip3 homozygotes.

      zipScer\UAS.T:Avic\GFP driven by the longitudinal visceral muscle drivers Scer\GAL4NP221 or Scer\GAL4tey-5053A fails to rescue the loss of rotation in the proventriculus and anterior midgut seen in zip3 homozygotes.

      zipScer\UAS.T:Avic\GFP driven by the drivers Scer\GAL4NP5021, Scer\GAL4drm.7.1, Scer\GAL4byn-Gal4, Scer\GAL4elav-C155 or Scer\GAL4wg.PM fails to rescue the loss of rotation in the proventriculus and anterior midgut seen in zip3 homozygotes.

      Expression of zipScer\UAS.T:Avic\GFP driven by Scer\GAL4wg.PM suppresses the dorsal closure defects found in zip3 homozygotes although the no-rotation phenotype is not suppressed.

      Expression of zipScer\UAS.T:Avic\GFP driven by Scer\GAL4wg.PM suppresses the dorsal closure defects found in zip4 homozygotes although the no-rotation phenotype is not suppressed.

      Expression of zipScer\UAS.T:Avic\GFP continuously in a non-permissive temperature (32[o]C), under the control of Scer\GAL4da.G32 and Scer\GAL80ts.αTub84B, rescues the laterality defects found in zip3 mutants. The zip3 rotation defects are not rescued when the 1 hour shift to the non-permissive temperature occurs from stage 14 onwards. The temperature shift applied from 16 to 17 hours after egg laying(AEL), which corresponds to stage 12, leads to the most efficient rescue of the laterality defects associated with zip3 mutants. However, expression of zipScer\UAS.T:Avic\GFP after 22 hours AEL, corresponding to stage 14, does not rescue the laterality, 'no rotation' phenotype.

      zipScer\UAS.T:Avic\GFP driven by Scer\GAL4how-24B partially rescues the loss of side specific rearrangement in circular visceral muscle cells seen in zip3 homozygotes. The failure of the circular visceral muscle midline to rotate in relation to the midline of the embryo is also partially rescued.

      (Okumura et al., 2010)

      Expression of zipScer\UAS.T:Avic\GFP, driven by Scer\GAL4mat.αTub67C.T:Hsim\VP16, allows 34% of zip1 mutants to hatch and undergo larval development, instead of dying as embryos.

      (Barros et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      zipScer\UAS.T:Avic\GFP
      zipUAS.mGFP6
      Name Synonyms
      Secondary FlyBase IDs
        References (3)