FlyBase Allele Report: Dmel\dpp[TgR46.1]

General Information

Symbol

Dmel\dpp^TgR46.1

Species

D. melanogaster

Name

FlyBase ID

FBal0193758

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Stultz et al., 2006, Stultz et al., 2005)

Progenitor genotype

dpp^Tg

(Stultz et al., 2005)

Caused by aberration

In(2L)dpp^TgR46.1

Cytology

Description

Carries a lesion in the 5'end of the dpp gene between nucleotides 70 and 72, within the shortvein cis-regulatory region.

(Stultz et al., 2006)

Distal breakpoint between positions 71 and 72.2 on the dpp molecular map (coordinates according to FBrf0051824).

(Stultz et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Df(2L)DTD2, dpp^Sal20

(Stultz et al., 2006)

increased cell death (with Df(2L)DTD2), with dpp^Sal20

(Stultz et al., 2006)

lethal (with dpp^s20)

(Stultz et al., 2005)

lethal (with dpp^s22)

(Stultz et al., 2005)

lethal - all die during embryonic stage | recessive

(Stultz et al., 2005)

partially lethal - majority die (with dpp^s7)

(Stultz et al., 2005)

partially lethal - majority die (with dpp^s13)

(Stultz et al., 2005)

some die during embryonic stage | recessive

(Stultz et al., 2005)

viable (with dpp^d5)

(Stultz et al., 2005)

viable (with dpp^d6)

(Stultz et al., 2005)

viable (with dpp^d12)

(Stultz et al., 2005)

visible, with Df(2L)DTD2, dpp^Sal20

(Stultz et al., 2006)

visible (with Df(2L)DTD2), with dpp^Sal20

(Lee et al., 2007, Stultz et al., 2006)

visible (with dpp^s7)

(Stultz et al., 2005)

visible (with dpp^s11)

(Stultz et al., 2005)

visible (with dpp^s13)

(Stultz et al., 2005)

visible (with dpp^s-hc1)

(Stultz et al., 2005)

Phenotype Manifest In

adult head | ventral (with Df(2L)DTD2), with dpp^Sal20

(Lee et al., 2007)

adult head capsule (with dpp^s7)

(Stultz et al., 2005)

adult head capsule (with dpp^s11)

(Stultz et al., 2005)

adult head capsule (with dpp^s13)

(Stultz et al., 2005)

adult head capsule (with dpp^s-hc1)

(Stultz et al., 2005)

eye, with Df(2L)DTD2, dpp^Sal20

(Stultz et al., 2006)

eye (with Df(2L)DTD2), with dpp^Sal20

(Lee et al., 2007, Stultz et al., 2006)

eye-antennal disc, with Df(2L)DTD2, dpp^Sal20

(Stultz et al., 2006)

eye-antennal disc (with Df(2L)DTD2), with dpp^Sal20

(Stultz et al., 2006)

gena, with Df(2L)DTD2, dpp^Sal20

(Stultz et al., 2006)

gena (with Df(2L)DTD2), with dpp^Sal20

(Lee et al., 2007, Stultz et al., 2006)

maxillary palp, with Df(2L)DTD2, dpp^Sal20

(Stultz et al., 2006)

maxillary palp (with Df(2L)DTD2), with dpp^Sal20

(Lee et al., 2007, Stultz et al., 2006)

ommatidium, with Df(2L)DTD2, dpp^Sal20

(Stultz et al., 2006)

ommatidium (with Df(2L)DTD2), with dpp^Sal20

(Stultz et al., 2006)

rostral membrane | anterior, with Df(2L)DTD2, dpp^Sal20

(Stultz et al., 2006)

rostral membrane | anterior (with Df(2L)DTD2), with dpp^Sal20

(Stultz et al., 2006)

vibrissal bristle, with Df(2L)DTD2, dpp^Sal20

(Stultz et al., 2006)

vibrissal bristle (with Df(2L)DTD2), with dpp^Sal20

(Lee et al., 2007, Stultz et al., 2006)

Detailed Description

Statement

Reference

In dpp^TgR46.1/Df(2L)DTD2, dpp^Sal20 flies the ventral head is disrupted, the eye is round rather than oval, the sensory vibrissae on the ventral side of the eye are bunched, the maxillary palps are missing, reduced or duplicated, and gena tissue appears to be missing.

(Lee et al., 2007)

dpp^TgR46.1/Df(2L)DTD2, dpp^Sal20 flies show head capsule defects. The sensory vibrissae on the ventral side of the head are disrupted, with vibrissae missing at the posterior end, and bunched or duplicated at the anterior end. The maxillary palps are either missing, reduced or are sometimes duplicated. In extreme cases, both the anterior rostral membrane and gena tissue are greatly diminished. The eyes are round instead of oval and are small due to a small, but statistically significant reduction in ommatidia number.

Third star imaginal discs appear normal in size and shape in dpp^TgR46.1/Df(2L)DTD2, dpp^Sal20 larvae.

Third star dpp^TgR46.1/Df(2L)DTD2, dpp^Sal20 eye-antennal discs show increased cell death, particularly in the disc proper.

(Stultz et al., 2006)

dpp^s-hc1/dpp^TgR46.1 adults have normal wings but show head capsule defects.

(Stultz et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

dpp^TgR46.1/dpp[+], opa⁸ has visible phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has visible phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^32.3 has visible phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^Q has visible phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^M has visible phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has visible phenotype

(Lee et al., 2007)

Phenotype Manifest In

Other

Statement

Reference

dpp^TgR46.1/dpp[+], opa⁸ has eye phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has adult head | ventral phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has gena phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has eye phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has vibrissal bristle phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has maxillary palp phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has adult head | ventral phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^12.3 has gena phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^32.3 has eye phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁸ has vibrissal bristle phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^32.3 has vibrissal bristle phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^32.3 has maxillary palp phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^32.3 has adult head | ventral phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^32.3 has gena phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^Q has eye phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^Q has vibrissal bristle phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^Q has maxillary palp phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^Q has adult head | ventral phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^Q has gena phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁸ has maxillary palp phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^M has eye phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^M has vibrissal bristle phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^M has maxillary palp phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^M has adult head | ventral phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa^M has gena phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁸ has adult head | ventral phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁸ has gena phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has eye phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has vibrissal bristle phenotype

(Lee et al., 2007)

dpp^TgR46.1/dpp[+], opa⁷ has maxillary palp phenotype

(Lee et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The ventral head is disrupted, the eye is round rather than oval, the sensory vibrissae on the ventral side of the eye are bunched, the maxillary palps are missing, reduced or duplicated, and gena tissue appears to be missing in flies of the following genotypes: dpp^TgR46.1/+; opa⁷/+, dpp^TgR46.1/+; opa⁸/+, dpp^TgR46.1/+; opa^12.3/+, dpp^TgR46.1/+; opa^32.3/+, dpp^TgR46.1/+; opa^Q/+, dpp^TgR46.1/+; opa^M/+, dpp^TgR46.1/+; Df(3R)6-7, dpp^TgR46.1/+; Df(3R)Z1, dpp^TgR46.1/+; Df(3R)110 and dpp^TgR46.1/+; Df(3R)63.

(Lee et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

dpp^s6

(Stultz et al., 2005)

dpp^d12

(Stultz et al., 2005)

dpp^d6

(Stultz et al., 2005)

dpp^d5

(Stultz et al., 2005)

Comments

Expression of dpp^Scer\UAS.cNa under the control of Scer\GAL4^dpp.s-hc at 29^oC causes an almost complete rescue of the head capsule defects of dpp^TgR46.1/Df(2L)DTD2, dpp^Sal20 mutants. Expression at 27^oC is less effective and causes a 55% reduction in penetrance while expression at 25^oC results in a 22% reduction in penetrance.

(Stultz et al., 2006)

dpp^TgR46.1 fully complements the wing vein defects of dpp^s6.

(Stultz et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Revertant of dpp^Tg phenotype.

(Stultz et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

TgR46.1

(Stultz et al., 2005)

dpp^TgR46.1

(Stultz et al., 2012, Lee et al., 2007, Stultz et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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