FlyBase Allele Report: Dmel\acs[GS10666]

General Information

Symbol

Dmel\acs^GS10666

Species

D. melanogaster

Name

FlyBase ID

FBal0193816

Feature type

allele

Associated gene

Dmel\acs

Associated Insertion(s)

P{GSV6}acs^GS10666

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Goberdhan et al., 2005)

Progenitor genotype

Associated Insertion(s)

P{GSV6}acs^GS10666

Cytology

Description

A P{GSV6} element is inserted near the CG1139 gene.

(Goberdhan et al., 2005)

Allele components

Component

Use(s)

Inserted element

P{GSV6}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:1,970,108..1,970,108

(Goberdhan et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number, with Scer\GAL4^Bx-MS1096, acs^UAS.cGb

(Goberdhan et al., 2005)

decreased cell number (with acs^GS7120), with Scer\GAL4^Bx-MS1096

(Goberdhan et al., 2005)

increased cell number, with Scer\GAL4^Bx-MS1096

(Goberdhan et al., 2005)

increased cell number, with Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

eye (with acs^GS7120), with Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

ommatidium, with Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

ommatidium (with acs^GS7120), with Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

wing, with Scer\GAL4^Bx-MS1096

(Goberdhan et al., 2005)

wing, with Scer\GAL4^Bx-MS1096, acs^UAS.cGb

(Goberdhan et al., 2005)

wing (with acs^GS7120), with Scer\GAL4^Bx-MS1096

(Goberdhan et al., 2005)

Detailed Description

Statement

Reference

Overexpression of CG1139^GS10666, under the control of Scer\GAL4^GMR.PF, increases both ommatidial and overall eye size.

When CG1139^GS10666 and CG1139^GS7120 are coexpressed under the control of Scer\GAL4^GMR.PF the resulting eyes bulge more from the head capsule and the ommatidial array is mildly disorganised.

In flies expressing CG1139^GS10666 throughout the developing adult wing, driven by Scer\GAL4^Bx-MS1096, overall wing size is increased and excess growth on the dorsal surface causes the wing to turn down.

Although expression of CG1139^GS10666, under the control of Scer\GAL4^Bx-MS1096 promotes growth in the wing, coexpression with CG1139^GS7120 significantly reduces growth. In addition , co-expression of CG1139^GS10666 with CG1139^Scer\UAS.cGb, also driven by Scer\GAL4^Bx-MS1096, enhances the growth inhibitory effect of the CG1139^Scer\UAS.cGb transgene.

(Goberdhan et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, acs^GS10666 has increased cell number phenotype, enhanceable by Scer\GAL4^GMR.PF, mTor^{WT.UAS.Tag:FLAG}

(Goberdhan et al., 2005)

Enhancer of

Statement

Reference

acs^GS10666, Scer\GAL4^Bx-MS1096 is an enhancer of decreased cell number phenotype of Scer\GAL4^Bx-MS1096, mTor^{WT.UAS.Tag:FLAG}

(Goberdhan et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^arm.PS/acs^GS10666 is a suppressor of decreased body size phenotype of path^KG06640

(Goberdhan et al., 2005)

Scer\GAL4^arm.PS/acs^GS10666 is a suppressor of decreased cell number phenotype of path^KG06640

(Goberdhan et al., 2005)

Scer\GAL4^arm.PS/acs^GS10666 is a suppressor of decreased cell size phenotype of path^KG06640

(Goberdhan et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, acs^GS10666 has eye phenotype, enhanceable by Scer\GAL4^GMR.PF, mTor^{WT.UAS.Tag:FLAG}

(Goberdhan et al., 2005)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, acs^GS10666, foxo^GS9928 has ommatidium phenotype, suppressible by Scer\GAL4^GMR.PF/Akt^UAS.cSa

(Goberdhan et al., 2005)

Enhancer of

Statement

Reference

acs^GS10666, Scer\GAL4^Bx-MS1096 is an enhancer of wing phenotype of Scer\GAL4^Bx-MS1096, mTor^{WT.UAS.Tag:FLAG}

(Goberdhan et al., 2005)

acs^GS10666, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF, foxo^GS9928

(Goberdhan et al., 2005)

Suppressor of

Statement

Reference

acs^GS10666 is a suppressor of wing phenotype of path^KG06640

(Goberdhan et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

When cooverexpressed with CG1139^GS10666, under the control of Scer\GAL4^GMR.PF, Tor^{WT.Scer\UAS.T:Zzzz\FLAG} significantly enhances the overgrowth phenotype induced by CG1139^GS10666 alone.

CG1139^GS10666 significantly enhances the reduced wing phenotype produced by overexpressing Tor^{WT.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^Bx-MS1096.

The path^KG06640 reduced weight and small wing phenotypes are significantly rescued by expression of CG1139^GS10666 under the control of Scer\GAL4^arm.PS.

Co-expression of foxo^GS9928 with CG1139^GS10666, driven by Scer\GAL4^GMR.PF, enhances the foxo^GS9928 reduced eye phenotype, an effect that is completely suppressed by Akt1^Scer\UAS.cSa co-expression.

(Goberdhan et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG1139¹⁰⁶⁶⁶

(Goberdhan et al., 2005)

CG1139^GS10666

(Ogmundsdóttir et al., 2012)

acs^GS10666

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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